Veno-occlusive disease in children and adolescents after hematopoietic stem cell transplantation: Did the Modified Seattle Criteria fit the characteristics of pediatric population?

Szmit, Zofia; Gorczyńska, Ewa; Mielcarek‐Siedziuk, Monika; Ussowicz, Marek; Owoc‐Lempach, Joanna; Kałwak, Krzysztof

doi:10.17219/acem/115070

Cited by 8 publications

(3 citation statements)

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“…in their retrospective analysis of 951 HSCT procedures performed in 850 children and young adults found the VOD incidence 5.05% similar to ours. Publications that have focused strictly on VOD in children have reported incidence ranges from 13% to 28% 33 . This high variation in rates of VOD might be due to the diagnostic criteria used.…”

Section: Discussionmentioning

confidence: 99%

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Improvement of survival after hematopoietic stem cell transplantation and trends at a pediatric transplantation center; a three‐decade journey

Sezgin,

Öner,

İnan

et al. 2024

Pediatric Transplantation

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BackgroundAdvances in stem cell transplantation have resulted in improved outcomes.MethodsThis is a retrospective study aimed to analyze changes in patient profile, transplantation, graft characteristics, and outcome among 241 pediatric patients who received stem cell transplantation in a single center between 1993 and 2019.ResultsIn the 2010–2019, compared with the 1993–2009 period, a significantly higher 5‐year overall survival (60% vs. 44%, p = .022) and an event‐free survival (53% vs. 34%, p = .025) were observed. Cumulative incidence of deaths due to relapse or progression between the 1993–2009 and 2010–2019 periods were 33% and 26% respectively (p = .66). Cumulative incidence of non‐relapse mortality was significantly higher during the 1993–2009 period compared with the 2010–2019 period for malignant diseases (57.7% vs. 28.3%, p = .007). The overall survival from acute graft‐versus‐host disease between 1993 and 2009 was 11% versus 46% between 2010 and 2019 (p = .0001). The overall survival from infection in both eras did not show any difference (p = .41).ConclusionsDevelopment in transplantation technology has led to a decrease in non‐relapse mortality and better control of graft‐versus‐host disease. However, relapse and infection remained as major causes of death. Studies evaluating institutional trends in patients undergoing HSCT and analyzing their mortality profile, can improve the management of patients, leading to a reduction in transplant‐related problems.

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Section: Discussionmentioning

confidence: 99%

“…Publications that have focused strictly on VOD in children have reported incidence ranges from 13% to 28%. 33 This high variation in rates of VOD might be due to the diagnostic criteria used.…”

Section: Discussionmentioning

confidence: 99%

Improvement of survival after hematopoietic stem cell transplantation and trends at a pediatric transplantation center; a three‐decade journey

Sezgin,

Öner,

İnan

et al. 2024

Pediatric Transplantation

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“…In the more recent adult and paediatric EBMT criteria, additional factors are considered and the severity of VOD/SOS is based on multiple elements, including liver enzyme and bilirubin levels, international normalised ratio for coagulation, ascites, weight gain, renal function, encephalopathy, persistent refractory thrombocytopaenia and pulmonary function [ 5 , 21 ]. As use of these more recent, sensitive VOD/SOS diagnostic criteria becomes more widespread, leading to a greater recognition of conditions such as anicteric or late-onset VOD/SOS, it is possible that the incidence of VOD/SOS post-HCT will increase [ 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review and Meta-Analysis of Studies of Defibrotide Prophylaxis for Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome

2022

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Background and Objectives Defibrotide is approved to treat severe veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) after haematopoietic cell transplantation in patients aged > 1 month in the European Union and for VOD/SOS with renal/pulmonary dysfunction post-haematopoietic cell transplantation in the United States. This meta-analysis estimated the incidence and risk of VOD/SOS after intravenous defibrotide prophylaxis using the published literature. Methods PubMed, Embase and Web of Science were searched through 30 November 2021 for defibrotide studies in VOD/SOS “prevention” or “prophylaxis,” excluding phase I studies, case reports, studies with fewer than ten patients and reviews. Results The search identified 733 records; 24 met inclusion criteria, of which 20 ( N = 3005) evaluated intravenous defibrotide for VOD/SOS prophylaxis. Overall VOD/SOS incidence with intravenous defibrotide was 5%, with incidences of 5% in adults and 8% in paediatric patients. In eight studies with data on intravenous defibrotide prophylaxis vs controls (e.g. heparin, no prophylaxis), VOD/SOS incidence in controls was 16%. The risk ratio for developing VOD/SOS with defibrotide prophylaxis vs controls was 0.30 (95% confidence interval 0.12–0.71; p = 0.006). Conclusions This analysis suggests a low incidence of VOD/SOS following intravenous defibrotide prophylaxis, regardless of age group, and a lower relative risk for VOD/SOS with defibrotide prophylaxis vs controls in patient populations at high risk of VOD/SOS.

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GI and Liver Transplantation Pathology in Childhood

Ranganathan

2024

Pathology of Pediatric Gastrointestinal and Liver Disease

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Veno-occlusive disease in children and adolescents after hematopoietic stem cell transplantation: Did the Modified Seattle Criteria fit the characteristics of pediatric population?

Cited by 8 publications

References 0 publications

Improvement of survival after hematopoietic stem cell transplantation and trends at a pediatric transplantation center; a three‐decade journey

Improvement of survival after hematopoietic stem cell transplantation and trends at a pediatric transplantation center; a three‐decade journey

A Systematic Review and Meta-Analysis of Studies of Defibrotide Prophylaxis for Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome

GI and Liver Transplantation Pathology in Childhood

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