Venom-Derived Bioactive Compounds as Potential Anticancer Agents: A Review

Roy, Arpita

doi:10.1007/s10989-020-10073-z

Cited by 23 publications

(13 citation statements)

References 98 publications

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“…BV can desensitize mast cells and basophils ( 57 ) and suppress innate lymphoid cells. BV materials can inhibit proteinsynthesis, induce angiogenesis ( 58 ) and activate caspase-3-8-9 ( 59 ) ( Table 1 ).…”

Section: Bee Venom Therapymentioning

confidence: 99%

Bee Venom—A Potential Complementary Medicine Candidate for SARS-CoV-2 Infections

Kasozi

Niedbała

Alqarni

et al. 2020

Front. Public Health

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by severe cytokine storm syndrome following inflammation. SARS-CoV-2 directly interacts with angiotensin-converting enzyme 2 (ACE-2) receptors in the human body. Complementary therapies that impact on expression of IgE and IgG antibodies, including administration of bee venom (BV), have efficacy in the management of arthritis, and Parkinson's disease. A recent epidemiological study in China showed that local beekeepers have a level of immunity against SARS-CoV-2 with and without previous exposure to virus. BV anti-inflammatory properties are associated with melittin and phospholipase A2 (PLA2), both of which show activity against enveloped and non-enveloped viruses, including H1N1 and HIV, with activity mediated through antagonist activity against interleukin-6 (IL-6), IL-8, interferon-γ (IFN-γ), and tumor necrosis factor-α (TNF-α). Melittin is associated with the underexpression of proinflammatory cytokines, including nuclear factor-kappa B (NF-κB), extracellular signal-regulated kinases (ERK1/2), and protein kinase Akt. BV therapy also involves group III secretory phospholipase A2 in the management of respiratory and neurological diseases. BV activation of the cellular and humoral immune systems should be explored for the application of complementary medicine for the management of SARS-CoV-2 infections. BV “vaccination” is used to immunize against cytomegalovirus and can suppress metastases through the PLA2 and phosphatidylinositol-(3,4)-bisphosphate pathways. That BV shows efficacy for HIV and H1NI offers opportunity as a candidate for complementary therapy for protection against SARS-CoV-2.

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Section: Bee Venom Therapymentioning

confidence: 99%

Bee Venom—A Potential Complementary Medicine Candidate for SARS-CoV-2 Infections

Kasozi

Niedbała

Alqarni

et al. 2020

Front. Public Health

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“…Many other toxins and chemicals use similar pore-forming mechanisms as anoplin and have been pursued for their ability to kill cells [202,203]. In fact some current chemotherapy drugs work through a similar mechanisms and it is thought that proper targeting of poreforming toxins could present a new opportunity for selective cell death in cancer and other diseases [204][205][206]. Two A. mellifera toxins in particular, mellitin and mastoparan have been rather heavily studied for these and other effects and mastoparan in particular is similar to anoplin in that both are short helical transmembrane peptides [199].…”

Section: Discussionmentioning

confidence: 99%

A Short Review of the Venoms and Toxins of Spider Wasps (Hymenoptera: Pompilidae)

Dashevsky

Rodríguez

2021

Toxins

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Parasitoid wasps represent the plurality of venomous animals, but have received extremely little research in proportion to this taxonomic diversity. The lion’s share of investigation into insect venoms has focused on eusocial hymenopterans, but even this small sampling shows great promise for the development of new active substances. The family Pompilidae is known as the spider wasps because of their reproductive habits which include hunting for spiders, delivering a paralyzing sting, and entombing them in burrows with one of the wasp’s eggs to serve as food for the developing larva. The largest members of this family, especially the tarantula hawks of the genus Pepsis, have attained notoriety for their large size, dramatic coloration, long-term paralysis of their prey, and incredibly painful defensive stings. In this paper we review the existing research regarding the composition and function of pompilid venoms, discuss parallels from other venom literatures, identify possible avenues for the adaptation of pompilid toxins towards human purposes, and future directions of inquiry for the field.

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“…These venoms contain bioactive compounds such as proteins, salts, peptides and small molecules that have many pharmacological activities. Furthermore, isolated venoms have little toxic effects on normal cells and tissues and also can play a role in the induction of apoptosis signaling (Mirzaei et al, 2020;Roy and Bharadvaja, 2020). Initially, the results showed that the crude venom and its fraction B had the ability to reduce the viability of CLL B-lymphocytes.…”

Section: Fraction B Increased Ros Generation In Cll Blymphocytesmentioning

confidence: 99%

Cytotoxicity Studies of the Crude venom and Fractions of Persian Gulf Snail (Conus Textile) on Chronic Lymphocytic Leukemia and Normal Lymphocytes

Salimi

Salehian

Aboutorabi³

et al. 2021

Asian Pac J Cancer Prev

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Background: Marine animals have been considered by many researchers due to their various pharmacological effects. One group of marine animals that have been studied is cone snails. The conotoxin obtained from these marine animals has various therapeutic effects. Methods: This study was designed to investigate the apoptotic effects of crude venom of Conus textile and its fractions (A and B) on chronic lymphocytic leukemia (CLL) cells. Accordingly, parameters such as cell viability, reactive oxygen species (ROS) level, collapse in mitochondrial membrane potential (MMP), lysosomal membrane damage and caspase-3 activation were evaluated. Results: The results showed that the crude venom (50, 100 and 200 µg/ml) from Conus textile and its fraction B (50, 100 and 200 µg/ml) significantly reduced viability in CLL B-lymphocyte. In addition, exposure of CLL B-lymphocyte to fraction B (50, 100 and 200 µg/ml) was associated with an increase in the level of ROS, the collapse of the MMP, damage to the lysosomal membrane, and activation of caspase-3. Conclusion: According to results, it was concluded that fraction B from crude venom of Conus textile causes selective toxicity on CLL B-lymphocyte with almost no effect on a normal lymphocyte. Furthermore, this venom fraction could be a promising candidate for induction of apoptosis in patients with CLL through the mitochondrial pathway.

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Venom-Derived Bioactive Compounds as Potential Anticancer Agents: A Review

Cited by 23 publications

References 98 publications

Bee Venom—A Potential Complementary Medicine Candidate for SARS-CoV-2 Infections

Bee Venom—A Potential Complementary Medicine Candidate for SARS-CoV-2 Infections

A Short Review of the Venoms and Toxins of Spider Wasps (Hymenoptera: Pompilidae)

Cytotoxicity Studies of the Crude venom and Fractions of Persian Gulf Snail (Conus Textile) on Chronic Lymphocytic Leukemia and Normal Lymphocytes

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