Venom immunotherapy for preventing allergic reactions to insect stings

Elremeli, Mariam; Bulsara, Max; Daniels, Michael J.; Boyle, Robert

doi:10.1002/14651858.cd008838

Cited by 7 publications

(12 citation statements)

References 23 publications

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“…Side effects include superficial wheal and flare, local swelling (which may be immediate or delayed up to 48 hours), mild general reactions (urticaria, erythema, rhinitis or mild asthma) and moderate or severe general reactions (more severe asthma, angioedema or anaphylactic reaction with hypotension and respiratory embarrassment and possible death). 33 To place the current review in the context of the overall literature on the clinical effectiveness of VIT, the Assessment Group (AG) worked in collaboration with the Cochrane Skin Group to provide the best available summary of the evidence for the use of VIT in the treatment of Hymenoptera allergy.…”

Section: Contraindications/warningsmentioning

confidence: 99%

“…Three studies 55- Comparative studies of venom immunotherapy other than Pharmalgen Although the remit of this review was to assess the clinical effectiveness and cost-effectiveness of PhVIT for the treatment of bee and wasp venom allergy, as discussed in Chapter 1, Venom immunotherapy, there are other VIT products that are available to treat bee and wasp venom allergy. The searches for this review identified one meta-analysis 71 and two systematic reviews 33,72 reporting on comparative studies of non-PhVIT products in the population of interest, and an overview of the publications is given in Table 14.…”

Section: Observational Studies Of Pharmalgenmentioning

confidence: 99%

“…The AG assessed the systematic reviews 33,72 for quality using the Database of Abstracts of Reviews of Effects (DARE) quality assessment tool. 88 Both were shown to be of high quality ( Table 15).…”

Section: Observational Studies Of Pharmalgenmentioning

confidence: 99%

“…Both of the systematic reviews 33,72 and the meta-analysis 71 conclude that VIT is effective in preventing future systemic reactions to venom in venom-allergic people.…”

Section: Observational Studies Of Pharmalgenmentioning

confidence: 99%

See 3 more Smart Citations

A systematic review of the clinical effectiveness and cost-effectiveness of Pharmalgen® for the treatment of bee and wasp venom allergy.

Hockenhull

Elremeli²,

Cherry³

et al. 2012

Health Technol Assess

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An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address.Paying by credit card You can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume.How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. NIHR Health Technology Assessment programmeThe Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service' . The HTA programme is needs led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projects. First is the commissioned route. Suggestions for research are ...

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Section: Contraindications/warningsmentioning

confidence: 99%

Section: Observational Studies Of Pharmalgenmentioning

confidence: 99%

Section: Observational Studies Of Pharmalgenmentioning

confidence: 99%

“…Both of the systematic reviews 33,72 and the meta-analysis 71 conclude that VIT is effective in preventing future systemic reactions to venom in venom-allergic people.…”

Section: Observational Studies Of Pharmalgenmentioning

confidence: 99%

See 2 more Smart Citations

A systematic review of the clinical effectiveness and cost-effectiveness of Pharmalgen® for the treatment of bee and wasp venom allergy.

Hockenhull

Elremeli²,

Cherry³

et al. 2012

Health Technol Assess

View full text Add to dashboard Cite

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“…Vetter (28) (8). Interesujące są wyniki ankietowe, w których ponad 34% ankietowanych zgłosiło incydent z użądleniem psa przez pszczołę, natomiast aż 28% przypadków zakończyło się jednoczesnym użądle-niem człowieka.…”

Section: Tab 1 śRednie Wartości Badanych Parametrów Morfologicznychunclassified

Clinical and behavioral aspects of bee stings in domestic dog

Karpinski¹,

Goleman²,

Czyzowski³

et al. 2016

Medycyna Weterynaryjna

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The aim of this study was to determine the scale of the phenomenon and the risks resulting from stings of domestic dog by bees. The material consisted of clinical interviews on dog disease history from four veterinary clin-ics. Twenty-six cases of stings were selected, in which the dog owner could positively identify the insect species that had stung a dog (on the basis of the external appearance of a dead bee or the presence of its sting). The select-ed dogs were grouped by sex and age: juveniles – aged up to 12 months and adults – aged more than 12 months. In addition, the grouping took into account the occurrence of pulmonary edema symptoms or lack thereof and the body response. Three types of body response were distinguished: a local reaction (M) in the form of erythema with edema, a large local reaction (MD), and anaphylaxis (pulmonary edema confirmed by X-ray examination). The following blood counts were evaluated: erythrocytes, leukocytes, lymphocytes, hematocrit value, hemoglobin con-centration, segmented neutrophils percentage, MCV, MCH, MCHC, as well as biochemical indices: AP, ALT, AST, creatinine, and BUN. Clinical and behavioral symptoms were analyzed with the use of a survey conducted with a randomly selected group of dog owners. To illustrate the scale of the problem, the survey on bee stings was conducted among 97 dog owners. An analysis of the coefficients of correlation between the values of the above parameters and the age of stung dogs showed that with dog’s age, there was a decrease in AP, lymphocyte and leukocyte levels, and an increase in hemoglobin levels percentage of segmented neutrophils, as well as hematocrit and erythrocyte counts. A statistically significant differ-ence was ascertained in AST, whose values were significantly higher in dogs without pulmonary edema (33.6 U/l ± 14.0) than in the group with edema (22.7 U/l ± 4.6), t (22) = 2.856; p = 0.01. A comparison of the average values of the parameters under analysis for both sexes revealed a significant difference between the average values of hemo-globin, which was significantly higher in males (16.6 g/dl ± 2.6), compared to females (14.1 g/dl ± 2.6), t (24) = 2,156; p = 0.041. The dogs were also classified into two groups according to the type of reaction: a local reaction or a large local reaction. Significantly greater differences were found in the average content of erythrocytes in dogs with a local reaction. Among all respondents, 35% reported their dogs having been stung by insects from the family Hymenoptera. Male dogs were stung twice as often as females, and almost half of the sting cases were dogs older than 4 years. Most of the stung dogs were kept in the backyard, and purebred dogs were stung more frequently than crossbreeds. Half of all cases were stings on the head, and the stung dogs usually reacted by strong hyperkinesia and slight vocalization (one point on a three-point scale).

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