Venous Ocular Blood Flow in Primary Open Angle Glaucoma

Курышева, Н. И.; Киселева, Т. Н.; Irtegova, Elena Y; Паршунина, О. А.

doi:10.19070/2332-290x-si03001

Cited by 5 publications

(6 citation statements)

References 35 publications

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“…We have recently revealed that ocular blood flow was significantly reduced both in NTG and HTG compared to healthy subjects. The reduction of arterial ocular blood flow was more significant in HTG than in NTG while the lower venous blood flow was detected in NTG patients [ 18 ]. It was emphasized in literature that the reduction of blood flow velocities in the central retinal vein and central retinal artery was significantly associated with glaucoma progression both in NTG and HTG patients with well controlled IOP (21 mmHg or less) [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

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Heart rate variability: the comparison between high tension and normal tension glaucoma

2018

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RelevanceVascular factors may be involved in the development of both high tension glaucoma (HTG) and normal tension (NTG) glaucoma; however, they may be not exactly the same. Autonomic dysfunction characterized by heart rate variability (HRV) is one of the possible reasons of decrease in mean ocular perfusion pressure (MOPP).PurposeTo compare the shift of the HRV parameters in NTG and HTG patients after a cold provocation test (CPT).MethodsMOPP, 24-hour blood pressure and HRV were studied in 30 NTG, 30 HTG patients, and 28 healthy subjects. The cardiovascular fitness assessment was made before and after the CPT. The direction and magnitude of the average group shifts of the HRV parameters after CPT were assessed using the method of comparing regression lines in order to reveal the difference between the groups.ResultsMOPP and minimum daily diastolic blood pressure were decreased in HTG and NTG patients compared to healthy subjects. There was no difference in MOPP between HTG and NTG before the CPT. However, all HRV parameters reflected the predominance of sympathetic innervation in glaucoma patients compared to healthy subjects (P < 0.05).Before the CPT, the standard deviation of NN intervals (SDNN) of HRV was lower in HTG compared to NTG, 27.2 ± 4.1 ms and 35.33 ± 2.43 ms (P = 0.02), respectively. After the CPT, SDNN decreased in NTG by 1.7 ms and increased in HTG and healthy subjects by 5.0 ms and 7.09 ms, respectively (P < 0.05). The analysis of relative shift of other HRV parameters after the CPT also revealed a significant difference between NTG and HTG in regard to the predominance of sympathetic innervation in NTG compared to HTG.ConclusionPatients with NTG have more pronounced disturbance of autonomic nervous system than HTG patients, which is manifested with the activation of sympathetic nervous system in response to CPT. This finding refers to the NTG pathogenesis and suggests the use of HRV assessment in glaucoma diagnosis and monitoring.

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Section: Discussionmentioning

confidence: 99%

“…A significant reduction of retrobulbar blood flow in NTG has been described in literature [ 17 , 18 ]. In addition, Kaiser et al demonstrated that ocular blood flow was reduced in both NTG patients and in those HTG patients which progressed despite a normal IOP [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Heart rate variability: the comparison between high tension and normal tension glaucoma

2018

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“…Indeed, according to the CDI data, the parameters of retrobulbar blood flow in NTG were reduced significantly compared to healthy eyes that is in consistent with our previous data. [ 15 ]…”

Section: Discussionmentioning

confidence: 99%

“…Pathological response to cold in patients with glaucoma has been previously demonstrated in our research [ 14 ] and we have described a significant reduction of retrobulbor blood flow in NTG. [ 15 ] Recently, some authors studied the peripheral blood flow in glaucoma patients after a cold provocation test (CPT) [ 1 ] and as a response to posture change. [ 16 ] Meanwhile, there is no literature data concerning the influence of CPT on HRV in NTG compared to healthy subjects.…”

Section: Introductionmentioning

confidence: 99%

Heart rate variability in normal tension glaucoma

2018

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Primary vascular dysregulation (PVD) is believed to be a main cause of local vasospasm and impaired autoregulation as a possible contributing factor in the pathogenesis of normal tension glaucoma (NTG). Subjects with PVD respond stronger to psychological stress. Autonomic dysfunction is another reason of instable ocular blood flow and may be studied by means of assessment of heart rate variability (HRV) especially during a hand-cold provocation test (CPT).To compare the shift of HRV parameters in NTG and healthy subjects after a cold provocation test and to assess the relation between structural damage, circulatory parameters and autonomic dysfunction in NTG.HRV was studied using CPT in 78 NTG patients and 60 health control matches. The ocular blood flow was measured using color Doppler imaging (CDI). The 24 hours blood pressure (BP) monitoring was carried out. The cardiovascular fitness assessment was made to all patients before and after CPT. Mean group difference of HRV parameters was compared between NTG and healthy subjects using the Euclidean metric. The mean ocular perfusion pressure (MOPP) was measured. Optic nerve head and retinal nerve fiber layer (RNFL) were evaluated using spectral-domain optic coherence tomography (SD-OCT). The relation between HRV, CDI, and SD-OCT-parameters was assessed.In contrast to healthy subjects, a predominance of the sympathetic activity after the CPT was revealed in the NTG group. The end diastolic velocity (EDV) in central retinal artery (CRA) and short posterior ciliary artery (SPCA) was significantly reduced in NTG compared to healthy eyes. In NTG, the main HRV parameter characterizing the total effect of autonomic blood circulation regulation (SDNN) correlated with MOPP (0.75, P = .035), SPCA EDV (0.93, P < .001), and CRA EDV (0.9, P < .001). The average daily diastolic BP correlated with RNFL (0.67, P = .009).The NTG patients have the disturbance of the autonomic nervous system, which increases in response to stress provocation and is related to ocular blood flow and structural damage.

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“…Особенностью ПОУГ является бессимптомное течение и довольно сложная и трудоемкая диагностика на начальных стадиях, поэтому выявление данного заболевания в большинстве случаев происходит на стадиях, сопровождающихся уже необратимыми изменениями зрительного нерва [5]. ПОУГ -одна из главных причин слабовидения и слепоты среди лиц трудоспособного возраста в развитых странах [6].…”

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The contribution of gene-gene interactions of polymorphic loci of matrix metalloproteinases to susceptibility to primary open-angle glaucoma in men

Svinareva¹

2020

RR. in B.

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Аннотация Актуальность: Первичная открытоугольная глаукома (ПОУГ) относится к одной из самых распространенных и тяжелых форм заболеваний глаз, приводящих к слепоте и инвалидности. Глаукома у мужчин встречается в более чем половине случаев (65%). Цель исследования: Изучить вклад ген-генных взаимодействий полиморфных локусов матриксных металлопротеиназ в подверженность к первичной открытоугольной глаукоме у мужчин. Материалы и методы: Выборка для исследования включала 236 мужчин с ПОУГ (диагноз был подтвержден клиническими, инструментальными и лабораторными методами обследования) и 176 мужчин контрольной группы, не имеющих данного заболевания. Проведено молекулярно-генетическое исследование 8 полиморфных локусов генов матриксных металлопротеиназ (MMP). Изучение SNP×SNP взаимодействий, ассоциированных с развитием ПОУГ, проводилось с использованием программы АРSampler. Результаты: Установлено 16 моделей SNP×SNP взаимодействий генов MMP (4 двухлокусных, 7 трехлокусных и 5 четырехлокусных) определяющих подверженность к развитию ПОУГ у мужчин (pperm<0,05), среди которых 6 моделей являются протективными и 10 моделей-факторы риска развития ПОУГ (OR=1,80-9,26). В состав моделей входят все 8 изучаемых нами полиморфных локусов MMP: rs3918249, rs3787268, rs2250889, rs17577, rs17576, rs3918242 гена ММР-9, rs1799750 гена ММР-1, rs679620 гена ММР-3. При этом два полиморфизма (rs1799750 ММР-1 и rs2250889 ММР-9) включены в наибольшее количество моделей (10 и 8 моделей соответственно). Полиморфные локусы rs1799750 и rs2250889 имеют важное функциональное значение в организме-проявляют эпигенетические эффекты, ассоциированы с уровнем экспрессии (cis-eQTL) генов MMP1, MMP10, WTAPP1, PLTP, PCIF1, NEURL2 и уровнем альтернативного сплайсинга транскрипта гена SLC12A5, определяют несинонимическую замену в гене MMP-9 (p.Arg574Pro). Заключение: Межгенные взаимодействия полиморфных локусов ММР ассоциированы с формированием ПОУГ у мужчин. Ключевые слова: матриксные металлопротеиназы; SNP×SNP взаимодействия; ПОУГ; полиморфизм; мужчины Благодарности: Работа выполнена при финансовой поддержке гранта Президента Российской Федерации для ведущих научных школ Российской Федерации (проект НШ-2609.2020.7). Для цитирования: Свинарева ДИ. Вклад ген-генных взаимодействий полиморфных локусов матриксных металлопротеиназ в подверженность к первич-Оригинальная статья Original article Свинарева ДИ. Вклад ген-генных взаимодействий полиморфных … Svinareva DI. The contribution of gene-gene interactions of polymorphic … 64

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Venous Ocular Blood Flow in Primary Open Angle Glaucoma

Abstract: However few of them mention the role of venous blood flow in glaucoma and explore its link to disk hemorrhages, retinal vein occlusion [18] and retinal venous pulsation [14,15].The purpose of our study was to evaluate venous blood flow in Special Issue on "Understanding Glaucoma"

Cited by 5 publications

References 35 publications

Heart rate variability: the comparison between high tension and normal tension glaucoma

Heart rate variability: the comparison between high tension and normal tension glaucoma

Heart rate variability in normal tension glaucoma

The contribution of gene-gene interactions of polymorphic loci of matrix metalloproteinases to susceptibility to primary open-angle glaucoma in men

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