Venous Valve Transplantation in Postphlebitic and Postthrombotic Veins

Waddell, W. G.; Prudhomme, P.; Ewing, Julie; Connock, S. H. G.

doi:10.1001/archsurg.1967.01330170134017

Cited by 11 publications

(3 citation statements)

References 4 publications

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“…An isolated segment of femoral vein was emptied of blood and filled with 5% ethanolamine for approximately 5 minutes and then declamped. 15 Only 30% of animals were technically useful for transplantation due to densely adherent collaterals and surrounding soft tissue inflammation. No autogenous valve containing vein transplant remained patent or competent in shortterm follow-up (Table I).…”

Section: Insufficiency Modelsmentioning

confidence: 99%

“…The isolated segment was filled with blood, bulldog clamps are applied above and below the area of trauma, and the dogs were reoperated in 2-4 days to remove the bulldog clamps. 15,17 Recanalization generally resulted in an acceptable model for venous valve transplantation (Table I). The addition of 24 hours of perioperative systemic heparinization to the venous valve transplantation improved the primary patency rate to ∼85% with a reported valve competency rate of ∼70%.…”

Section: Insufficiency Modelsmentioning

confidence: 99%

“…Interestingly, if the transplant occluded, regrafting with an external jugular vein valvecontaining segment and utilizing 24 hours of systemic heparinization demonstrated a 40% patency yet a 80% overall competency rate. 15 It was impossible to determine if the competent valves noted after venographically proven graft thrombosis had actually been involved with the thrombotic process.…”

Section: Insufficiency Modelsmentioning

confidence: 99%

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Animal Models for the Study of Lower Extremity Chronic Venous Disease: Lessons Learned and Future Needs

Dalsing

Ricotta

Wakefield

et al. 1998

Annals of Vascular Surgery

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The purpose of this review is to define animal models of chronic venous disease and to demonstrate how animal studies can impact our understanding and treatment of this disorder. To this end an extensive literature search was conducted highlighting potential animal models of chronic lower extremity venous disease. Scientific investigations using animals to study particular aspects of this disease are also reviewed. This review was conducted by members of the Committee on Research of the American Venous Forum to help provide direction for future venous research endeavors. Useful models of chronic venous occlusive disease involve controlled ligation of a major lower limb vein and multiple tributaries. Such a model can provide sustained venous hypertension and studies using this model have confirmed that an isodiametric graft can provide early hemodynamic relief. Models of primary, postphlebitic, and isolated chronic deep venous insufficiency are available for study. Valve repair or transplantation can positively impact the insufficiency observed in these models. Investigations into valve substitutes have generally been disappointing or are undergoing early evaluation. In conclusion, animal models for the study of some aspects of chronic venous disease do exist and have already affected our clinical approach to patients. The scientific study of basic pathophysiology, diagnostics, end-organ response, and long-term surgical treatments of this disorder in well-controlled animal experiments have not been conducted.

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Section: Insufficiency Modelsmentioning

confidence: 99%

Section: Insufficiency Modelsmentioning

confidence: 99%

Section: Insufficiency Modelsmentioning

confidence: 99%

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