Ventricular Hypertrophy and Hypertension

Krauser, Daniel G.; Devereux, Richard B.

doi:10.1007/s00059-006-2819-5

Cited by 53 publications

(10 citation statements)

References 71 publications

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“…According to the stepwise multiple linear regression analysis compensated with various clinical parameters along with baPWV and carotid IMT, BMD was a consistent and independent determinant for LVMI in female subjects (Table 6). These findings are comparable to that in previous studies, which reported that non-hemodynamic factors were more important in female subjects 19)20). Although more study is needed to clarify the causal relationship between low BMD and LVMI in postmenopausal women, hormonal changes in this population may be a possibility.…”

Section: Discussionsupporting

confidence: 89%

Bone Mineral Density is an Independent Determinant of Left Ventricular Mass Index in the General Female Population

et al. 2010

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Background and ObjectivesLeft ventricular hypertrophy (LVH) is a well known cardiovascular prognostic predictor. Osteoporosis has been suggested to be associated with cardiovascular disease. According to studies of primary hyperparathyroidism, a pathophysiological association between calcium metabolism and LVH has been suggested but is not yet fully understood. This study was performed to investigate the association between bone mineral density (BMD) and left ventricular mass index (LVMI) in a general population.Subjects and MethodsData from 460 subjects among 543 subjects sampled from a general population in a rural area in Korea were analyzed. BMD, echocardiography, brachial-ankle pulse wave velocity (baPWV), carotid intima-media thickness (IMT) measurement as well as the measurements of blood pressure, blood chemistry and metabolic parameters were analyzed. BMD was measured using the Sahara Clinical Bone Sonometer (Hologic Inc., Mass., USA).ResultsAge of the subjects was 59.4±12.4 years. Males were 42.2% (n=194). In a simple correlation analysis on female subjects, age and waist circumference showed negative correlation, and body mass index (BMI) showed positive correlation with BMD. However, only age showed negative correlation with BMD in male subjects. After adjusting baPWV and carotid IMT, we found that BMD was an independent determinant of LVMI in female subjects (β=-13.703, p=0.016), but not in male subjects (β=-1.235, p=0.841).ConclusionBMD is a consistent and independent determining factor of LVMI, BMI and carotid IMT in postmenopausal women.

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Section: Discussionsupporting

confidence: 89%

Bone Mineral Density is an Independent Determinant of Left Ventricular Mass Index in the General Female Population

et al. 2010

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“…Left ventricular hypertrophy (LVH) is one of the complications and is, in turn, an important risk factor for myocardial infarction, heart failure, stroke, and cardiac sudden death [4]. Blood pressure (BP) is the main determinant of the hemodynamic workload for the left ventricle and, in turn, of left ventricular mass (LVM) [5], although both hemodynamic and non-hemodynamic factors are involved in the complex pathogenesis of LVH [6], [7].…”

Section: Introductionmentioning

confidence: 99%

The Association of Left Ventricular Hypertrophy with Metabolic Syndrome is Dependent on Body Mass Index in Hypertensive Overweight or Obese Patients

et al. 2011

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BackgroundOverweight (Ow) and obesity (Ob) influence blood pressure (BP) and left ventricular hypertrophy (LVH). It is unclear whether the presence of metabolic syndrome (MetS) independently affects echocardiographic parameters in hypertension.Methods380 Ow/Ob essential hypertensive patients (age ≤65 years) presenting for referred BP control-related problems. MetS was defined according to NCEP III/ATP with AHA modifications and LVH as LVM/h2.7 ≥49.2 g/m2.7 in males and ≥46.7 g/m2.7 in females. Treatment intensity score (TIS) was used to control for BP treatment as previously reported.ResultsHypertensive patients with MetS had significantly higher BMI, systolic and mean BP, interventricular septum and relative wall thickness and lower ejection fraction than those without MetS. LVM/h2.7 was significantly higher in MetS patients (59.14±14.97 vs. 55.33±14.69 g/m2.7; p = 0.022). Hypertensive patients with MetS had a 2.3-fold higher risk to have LVH/h2.7 after adjustment for age, SBP and TIS (OR 2.34; 95%CI 1.40–3.92; p = 0.001), but MetS lost its independent relationship with LVH when BMI was included in the model.ConclusionsIn Ow/Ob hypertensive patients MetS maintains its role of risk factor for LVH independently of age, SBP, and TIS, resulting in a useful predictor of target organ damage in clinical practice. However, MetS loses its independent relationship when BMI is taken into account, suggesting that the effects on MetS on LV parameters are mainly driven by the degree of adiposity.

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“…The effects of anti-hypertensive drugs such as the lowering of BP and regression of LVH in proportion have been widely reported 22). However, the effect of anti-hypertensive drug classes on nocturnal BP has not been established.…”

Section: Discussionmentioning

confidence: 99%

Non-Dipper Pattern is a Determinant of the Inappropriateness of Left Ventricular Mass in Essential Hypertensive Patients

et al. 2011

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Background and ObjectivesInappropriately high left ventricular mass (iLVM) is known to be related to cardiovascular prognosis. A non-dipper pattern has a greater mean left ventricular (LV) mass than the dipper pattern in hypertensive patients. However, the appropriateness of LV mass in dipper or non-dipper patterns has not been adequately investigated. The aim of this study was to define the relationship between nocturnal dipping and the appropriateness of LV mass.Subjects and MethodsUsing the ambulatory blood pressure monitoring (ABPM) database, the data of 361 patients who underwent ABPM and echocardiography was analyzed retrospectively. Appropriateness of LV mass was calculated as observed/predicted ratio of LV mass (OPR) using a Korean-specified equation. Nocturnal dipping was expressed as percent fall in systolic blood pressure (BP) during the night compared to the day.ResultsDaytime, nighttime and 24 hours BP in hypertensive patients was 140.4±14.8 mmHg, 143.7±15.2 mmHg and 129.4±20.0 mmHg, respectively. OPR was 106.3±19.9% and nocturnal dipping was 10.2±10.9 mmHg. In a multiple linear regression model, 24 hours systolic BP (β=0.097, p=0.043) and nocturnal dipping (β=-0.098, p=0.046) were independent determinants of OPR as well as age (β=0.130, p=0.025) and body mass index (BMI) (β=0.363, p<0.001). Odds ratio of the non-dipper pattern was 2.134 for iLVM (p=0.021) and 3.694 for obesity (p<0.001; BMI >25 kg/m2).ConclusionThe non-dipper pattern is independently associated with iLVM in hypertensive patients as well as obesity.

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Ventricular Hypertrophy and Hypertension

Cited by 53 publications

References 71 publications

Bone Mineral Density is an Independent Determinant of Left Ventricular Mass Index in the General Female Population

Bone Mineral Density is an Independent Determinant of Left Ventricular Mass Index in the General Female Population

The Association of Left Ventricular Hypertrophy with Metabolic Syndrome is Dependent on Body Mass Index in Hypertensive Overweight or Obese Patients

Non-Dipper Pattern is a Determinant of the Inappropriateness of Left Ventricular Mass in Essential Hypertensive Patients

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