Ventricular Twist and Strain Alterations in Patients With Coarctation of the Aorta: A Novel Gradient Cine Mri With Strains Computed by Vector Velocity Imaging

Sahn, David J.; Niemann, Petra S; Houle, Helene; Broberg, Craig S.; Silberbach, Michael; Ashraf, Muhammad

doi:10.1016/s0735-1097(11)60841-3

Cited by 1 publication

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“…Age at intervention was the only variable correlated to LV GLS. This data is in agreement with the tendency shown by previous authors, who also observed older age at intervention as a predictor for LV longitudinal strain rate 8 and long axis dysfunction 35,36 . A possible explanation could be time of exposure to maladaptive fibrosis, myocyte degeneration, and myocyte loss 14 .…”

Section: Discussionsupporting

confidence: 93%

“…This study demonstrates reduced LV GLS in the majority of patients with CoA despite normal EF. These data suggest that CoA leads to subclinical LV dysfunction, which is not detectable by conventional echocardiography, with progressive improvement after stenting.Similarly, impaired LV GLS in patients with untreated CoA has also been demonstrated by several authors, employing different technologies including magnetic resonance imaging, tissue Doppler, and 2D and 3D speckle tracking.10,14,17,19,20,35 Our study is pioneering insofar as it shows one-year follow-up of We also show that deformation was worse in older patients, which may suggest that the sooner the treatment is performed, the better the chances of LV function preservation.…”

supporting

confidence: 73%

“…These data suggest that CoA leads to subclinical LV dysfunction, which is not detectable by conventional echocardiography, with progressive improvement after stenting. Similarly, impaired LV GLS in patients with untreated CoA has also been demonstrated by several authors, employing different technologies including magnetic resonance imaging, tissue Doppler, and 2D and 3D speckle tracking 10,14,17,19,20,35 …”

Section: Discussionmentioning

confidence: 60%

“…This data is in agreement with the tendency shown by previous authors, who also observed older age at intervention as a predictor for LV longitudinal strain rate 8 and long axis dysfunction. 35,36 A possible explanation could be time of exposure to maladaptive fibrosis, myocyte degeneration, and myocyte loss. 14 We did not find any correlations between GLS and the other variables, such as arm-leg gradient, isthmus gradient, hypertension, 37 or LV mass index.…”

Section: Correlation Between LV Gls and Clinical And Echocardiograpmentioning

confidence: 99%

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Myocardial strain pattern progress in patients with Coarctation of the Aorta undergoing aortic stenting

et al. 2020

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Background and Aim Ventricular function evaluation in coarctation of the aorta (CoA) has become more sophisticated and precise with speckle tracking, revealing subclinical changes. However, CoA stenting treatment effects in on myocardial strain are still controversial. This study aimed to estimate the extent to which changes in left ventricular global longitudinal strain (LV GLS) occur in patients with CoA who undergo stenting. Methods The study included 21 patients with CoA (median age: 15 years [8–39]) and 21 healthy individuals matched by age and gender. Clinical and echocardiographic evaluations were performed 1 day before, 6 months, and 1 year after stenting. Correlations between LV GLS and arm‐leg gradient, isthmus gradient on echocardiogram, age at intervention, left ventricular mass, and ejection fraction were tested. Results Before treatment, patients with CoA had lower LV GLS than the control group (−18.4% ± 1.96 vs −21.5% ± 1.37; P < .01), showing significant increase to −19.4% ± 2.1 at 6 months and −20.7% ± 2.19 at 1 year, P < .001. Only 28.5% (6 patients) had preserved GLS before treatment, improving to 80.9% (17 patients) in 1 year. The only variable correlated with low LV GLS values before treatment was age at intervention (Spearman's index = −0.571; P = .007). Conclusion Percutaneous therapy showed significant LV GLS improvement 12 months after aortic stenting. Older patients have lower GLS, suggesting that early intervention may have positive effects on preservation of LV systolic function.

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Section: Discussionsupporting

confidence: 93%