VentricularPatch Endocarditis Caused by Propionibacteriumacnes: Advantages of Gallium Scanning

Vandenbos, Fanny; Roger, Pierre‐Marie; Mondain-Miton, V.; Dunais, Brigitte; Fouche, R.; Kreitmann, P; D, Carles; Migneco, Octave; Dellamonica, P.

doi:10.1053/jinf.2001.0905

Cited by 15 publications

(6 citation statements)

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“…In this case, mutations in tlr9 resulting in suppression or enhancement of P. acnes reactivity may impair natural resistance to infections and tumor development or may lower the threshold of incidence of oral and bowel inflammatory diseases, respectively. P. acnes is associated with various human pathologies, such as acne vulgaris (53), endophtalmitis (54), endocarditis (55), osteomyelitis (56), sarcoidosis (57), and prosthetic hip infections (58), often together with other bacteria. The identification of TLR9 as an essential factor of P. acnes-induced hypersensitivity to TLR4-and TLR2-dependent microbial components demonstrates that the signaling events through one TLR can lead to a drastic enhancement of the degree of responsiveness of other TLRs.…”

Section: Discussionmentioning

confidence: 99%

Requirement for TLR9 in the Immunomodulatory Activity of Propionibacterium acnes

Kalis

Gumenscheimer

Freudenberg

et al. 2005

The Journal of Immunology

118

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Propionibacterium acnes (formerly Corynebacterium parvum) is part of the human flora and, as such, is associated with several human pathologies. It possesses strong immunomodulatory activities, which makes this bacterium interesting for prophylactic and therapeutic vaccination. The bacterial component(s) and the host receptor(s) involved in the induction of these activities are poorly understood. We show in this study that TLR9 is crucial in generating the characteristic effects of killed P. acnes priming in the spleen, such as extramedullary hemopoiesis and organ enlargement, and granuloma formation in the liver. Furthermore, the ability to overproduce TNF-α and IFN-γ in response to LPS, lipid A, synthetic lipopeptide Pam3CysK4, or whole killed bacteria was present in P. acnes-primed wild-type, but not TLR9−/−, mice. Finally, P. acnes priming failed to induce enhanced resistance to murine typhoid fever in TLR9−/− mice. Thus, TLR9 plays an essential role in the induction of immunomodulatory effects by P. acnes. Because IFN-γ is a key mediator of these effects, and enhanced IFN-γ mRNA expression was absent in spleen and liver of P. acnes-primed TLR9−/− mice, we conclude that TLR9 is required for the induction of IFN-γ by P. acnes.

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Section: Discussionmentioning

confidence: 99%

Requirement for TLR9 in the Immunomodulatory Activity of Propionibacterium acnes

Kalis

Gumenscheimer

Freudenberg

et al. 2005

The Journal of Immunology

118

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“…Historically P. acnes is considered to be of low virulence; however, in recent years it has been found as the aetiological agent in various pathologies. It is most notably implicated in the condition acne vulgaris [2] but is also associated with endophthalmitis [3], endocarditis [4], osteomyelitis [5], sarcoidosis [6] and prosthetic hip infections [7]. Recently P. acnes has been isolated from intervertebral disc material from patients with severe sciatica [8].…”

Section: Introductionmentioning

confidence: 99%

Analysis of clinical isolates ofPropionibacterium acnesby optimised RAPD

Perry

Worthington

Hilton

et al. 2003

FEMS Microbiology Letters

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Random amplification of polymorphic DNA (RAPD) was evaluated as a genotypic method for typing clinical strains of Propionibacterium acnes. RAPD can suffer from problems of reproducibility if parameters are not standardised. In this study the reaction conditions were optimised by adjusting template DNA concentration and buffer constituents. All isolates were typeable using the optimised RAPD protocol which was found to be highly discriminatory (Simpson's diversity index, 0.98) and reproducible. Typing of P. acnes by optimised RAPD is an invaluable tool for the epidemiological investigation of P. acnes for which no other widely accepted method currently exists.

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“…[3][4][5][6][7][8][9][10][11][12][13] Eight of these cases had previous cardiac operation history and prosthesis implantation. The duration between surgery and presentation of infective endocarditis varied from 3 weeks to 4 years.…”

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confidence: 99%