Venusol from Gunnera perpensa: structural and activity studies

Khan, Fatima; Peter, X.; Mackenzie, Rod M; Katsoulis, L.; Gehring, Ronette; Munro, Orde Q.; Heerden, Fanie R. van; Drewes, Siegfried E.

doi:10.1016/j.phytochem.2004.02.024

Cited by 26 publications

(11 citation statements)

References 11 publications

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“…The uterine contraction activity of Gunnera perpensa (Haloragaceae) has been reported (Khan et al, 2004). It is apparent that G. perpensa exerted its effect in milk yield through ejection by stimulating the contraction of myoepithelial cells which surround the epithelial cells of the alveoli and finer ducts.…”

Section: Discussionmentioning

confidence: 99%

“…Decoction prepared from it is also used to remove excess fluid from the body and to remove placenta after birth. Biological and pharmacology studies of various extracts and isolated compounds from the plant confirmed antibacterial activities (Drewes et (Nkomo et al, 2010), antioxidant activity (Simelane et al, 2010) and uterine contractile activity (Khan et al, 2004). Considering the extensive utilization of G. perpensa in Zulu traditional medicine, the present study was undertaken to investigate the rhizomes of G.perpensa for its effect on milk production in lactating rats.…”

Section: Introductionmentioning

confidence: 88%

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Lactogenic Activity of Rats Stimulated by <em>Gunnera Perpensa</em> L. (Gunneraceae) from South Africa

Simelane

Lawal²,

Djarova³

et al. 2012

Afr. J. Trad. Compl. Alt. Med.

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Gunnera perpensa L. (Gunneraceae) is a medicinal plant used by Zulu traditional healers to stimulate milk production. The effect of an aqueous extract of the rhizome of the plant on milk production in rats was investigated. Female lactating rats that received oral doses of the extract of G.perpensa significantly (p<0.05) produced more milk than controls. The plant extract did not however, significantly influence the levels of prolactin, growth hormone, progesterone, cortisol, ALT, AST and albumin in the blood. The mammary glands of rats treated with the extract showed lobuloalveolar development. The extract (0.8 μg/ml) was also found to stimulate the contraction of the uterus and inhibit (23%) acetylcholinesterase activity. The cytotoxicity of the extract (LC 50 ) to two human cell lines (HEK293 and HepG2) was 279.43 µg/ml and 222.33µg/ml, respectively. It is inferred that the plant extract exerts its activity on milk production and secretion by stimulating lobuloalveolar cell development and the contraction of myoepithelial cells in the alveoli. It is concluded that Gunnera perpensa contains constituents with lactogenic activity that apparently contribute to its effectiveness in folk medicine.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 88%

Lactogenic Activity of Rats Stimulated by <em>Gunnera Perpensa</em> L. (Gunneraceae) from South Africa

Simelane

Lawal²,

Djarova³

et al. 2012

Afr. J. Trad. Compl. Alt. Med.

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“…Various acids as well as venusol has been isolated from the rhizome of Gunnera perpensa (Khan et al, 2004). Although, venusol has been reported to stimulate a contractile response of the ileum and uterus muscles, no other activity has been reported thus far (Khan et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Studies on antibacterial, antioxidant and fibroblast growth stimulation of wound healing remedies from South Africa

Steenkamp

Mathivha

Gouws

et al. 2004

Journal of Ethnopharmacology

145

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“…Drewes et al [58] isolated 2-methyl-6-(-3-methyl-2-butenyl)benzo-1,4-quinone 7 , 3-hydroxy-2-methyl-5-(3-methyl-2-butenyl)benzo-1,4-quinone 8 , and 6-hydroxy-8-methyl-2,2-dimethyl-2H-benzopyran 9 from dichloromethane extract of the leaves and stems of G. perpensa while rans-phyt-2-enol 13 was isolated from methanol extracts of the aerial parts of the species. Khan et al [59] isolated trimethyl ether of ellagic acid glucoside 3 , Z-venusol, 7,8-dihydroxy-6-(hydroxymethyl)-3-[(Z)-(4-hydroxyphenyl)methylidene]tetrahydro-4aH-pyrano[2,3-b][1,4]dioxin-2-one 5 , lactic acid 11 , succinic acid 12, and pyrogallol 14 , from the aqueous extract of the dry rhizomes of G. perpensa .…”

Section: Phytochemistrymentioning

confidence: 99%

From Traditional Usage to Pharmacological Evidence: Systematic Review of Gunnera perpensa L.

Maroyi

2016

Evidence-Based Complementary and Alternative Medicine

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Gunnera perpensa is the only species of the genus Gunnera that has been recorded in Africa. Its leaves, rhizomes, roots, and stems are reported to possess diverse medicinal properties and used to treat or manage various human and animal diseases and ailments. Gunnera perpensa is an ingredient in many herbal concoctions and prescriptions which have been used to induce or augment labour, postnatal medication, to treat parasitic diseases, urinary complaints, kidney problems, general body pains, sexually transmitted infections, and many other diseases. Several classes of phytochemicals including alkaloids, benzoquinones, ellagic acids, flavonoids, phenols, proanthocyanidins, tannins, and minerals have been isolated from G. perpensa. Scientific studies on G. perpensa indicate that it has a wide range of pharmacological activities including acetylcholinesterase, anthelmintic, antibacterial, antifungal, antinociceptive, anti-inflammatory, antioxidant, antitumour, lactogenic, and uterotonic. Gunnera perpensa has a lot of potential as a possible source of pharmaceutical products for the treatment of a wide range of both human and animal diseases and ailments. Some of the chemical compounds isolated from G. perpensa have demonstrated various biological activities when investigated in in vitro assays. Future research should focus on the mechanisms of action of the isolated compounds, their efficacy, toxicity, and clinical relevance.

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Venusol from Gunnera perpensa: structural and activity studies

Cited by 26 publications

References 11 publications

Lactogenic Activity of Rats Stimulated by <em>Gunnera Perpensa</em> L. (Gunneraceae) from South Africa

Lactogenic Activity of Rats Stimulated by <em>Gunnera Perpensa</em> L. (Gunneraceae) from South Africa

Studies on antibacterial, antioxidant and fibroblast growth stimulation of wound healing remedies from South Africa

From Traditional Usage to Pharmacological Evidence: Systematic Review of Gunnera perpensa L.

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