Verb comprehension and naming in frontotemporal degeneration: The role of the static depiction of actions

d’Honincthun, Peggy; Pillon, Agnesa

doi:10.1016/j.cortex.2007.04.003

Cited by 43 publications

(21 citation statements)

References 37 publications

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“…Unlike the other Indo-European languages considered, Chinese lacks explicit word-class contrasts in its grammatical morphology, which suggests that neural noun-verb dissociations may be influenced by structural properties of the individual's native language. [57,58] (for further discussion of the model, see [48,59] [13,15], amyotrophic lateral sclerosis [14,60], corticobasal degeneration [61,62], and frontotemporal dementia [63,64]. This evidence A classic ACE (compatible facilitation and incompatible delay of RTs) was observed for controls, but no ACE was observed in early PD participants.…”

Section: Action-language Impairments In Parkinson's Diseasementioning

confidence: 88%

Words in motion: Motor-language coupling in Parkinson’s disease

García¹,

Ibáñez²

2014

Translational Neuroscience

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In recent years, the disruption of non-motor functions in motor disease has emerged as a promising topic for both basic and translational neuroscience. Impairments of movement and cognition were long regarded as separate phenomena [1]. However, a growing body of evidence indicates that neurodegenerative motor disorders also involve high-order cognitive dysfunctions, ranging from working memory, attention, and executive processing deficits [2][3][4], to impairments of language [4][5][6][7][8][9][10] and action knowledge [11]. Further data comes from studies showing that the same genes (e.g., C9orf72) are involved in diseases once perceived as purely motor or purely cognitive, such as motor neuron disease (MND) and frontotemporal dementia, respectively [12].A cognitive domain which seems to be specifically compromised in motor diseases is action language, that is, processing of linguistic stimuli denoting motor actions, including idioms (e.g., cut a rug) and action verbs Words in moTion: moTor-lAnguAge couPling in PArkinson's diseAse Abstract A growing body of evidence indicates that neurodegenerative motor disorders involved high-order cognitive dysfunctions. Crucially, evidence obtained in multiple behavioral, neuroimaging, and electrophysiological studies points to selective impairments of action language -that is, processing of linguistic stimuli denoting motor actions, including idioms (e.g., cut a rug) and action verbs (e.g., clap). Action-verb deficits (with relative preservation of noun processing) have been repeatedly documented in Parkinson's disease (PD). However, research on relevant biomarkers is still scant, and clinical implications of these findings have not yet been formally discussed. Relevant insights may be obtained through the assessment of motor-language coupling (i.e., the behavioral and neural integration of action-verb processing and ongoing motor actions). We propose that motorlanguage coupling deficits, as indexed by a cortical-subcortical network, may constitute an early neurocognitive marker of PD. Specifically, deficits in this domain at the prodromal stage may be detected through the actionsentence compatibility (ACE) paradigm, which induces a contextual coupling of ongoing motor actions and action-verb processing. Our translational proposal is supported and illustrated by recent studies demonstrating the sensitivity of the ACE technique as well as its potential to assist in differential diagnosis and interventionprogram design.

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Section: Action-language Impairments In Parkinson's Diseasementioning

confidence: 88%

Words in motion: Motor-language coupling in Parkinson’s disease

García¹,

Ibáñez²

2014

Translational Neuroscience

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“…While some patients with bvFTD demonstrate difficulty naming action words, this deficit has been shown to be associated with executive abilities, and may not reflect defective verb processing (i.e., retrieving the lexical features of verbs) per se (d’Honincthun & Pillon, 2008; Rhee et al, 2001; Silveri et al, 2003). One possibility is that verb naming requires access to a more elaborate set of linguistic and semantic information than naming nouns, and thus places greater demands on executive resources including working memory and selective attention (Silveri et al, 2003).…”

Section: Language In the Diagnosis Of Ftd Syndromesmentioning

confidence: 99%

Language, executive function and social cognition in the diagnosis of frontotemporal dementia syndromes

Harciarek

Cosentino

2013

International Review of Psychiatry

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Frontotemporal dementia (FTD) represents a spectrum of non-Alzheimer’s degenerative conditions associated with focal atrophy of the frontal and/or temporal lobes. Frontal and temporal regions of the brain have been shown to be strongly involved in executive function, social cognition and language processing and, thus, deficits in these domains are frequently seen in patients with FTD or may even be hallmarks of a specific FTD subtype ( i.e., relatively selective and progressive language impairment in primary progressive aphasia). In this review, we have attempted to delineate how language, executive function, and social cognition may contribute to the diagnosis of FTD syndromes, namely the behavioral variant FTD as well as the language variants of FTD including the three subtypes of primary progressive aphasia (PPA): non-fluent/agrammatic, semantic, and logopenic. This review also addresses the extent to which deficits in these cognitive areas contribute to the differential diagnosis of FTD versus AD. Finally, early clinical determinants of pathology are briefly discussed and contemporary challenges to the diagnosis of FTD are presented.

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“…(Thus we did not report the data from the naming to definition or video naming tasks administrated in few studies, e.g., Berndt et al, 1997;d'Honincthun & Pillon, 2008;Laiacona & Caramazza, 2004. ) For comprehension, we report the data from three types of task.…”

Section: Discussionmentioning

confidence: 95%

“…Second, the picture and/or word association task, which consisted in presenting triplets of pictures and/or written words and asking the patient to show which ones were semantically related. Third, for several studies (Breedin et al, 1998;d'Honincthun & Pillon, 2008;G. Robinson et al, 1999;Shapiro & Caramazza, 2003a, 2003bShapiro et al, 2000;Zingeser & Berndt, 1988), we report (also under the heading of "word association"), the data from a "synonymous task"; in this task, the patient is asked to tell whether pairs of words are synonymous, or which are the two synonymous words among a triplet of words.…”

Section: Discussionmentioning

confidence: 99%

“…(Yoon, Humphreys, & Riddoch, 2005) were more impaired in naming nouns than verbs but, in comprehension, they were more impaired with verbs than with nouns. In other cases (Appendix, Table A1(d)), the dissociation observed in comprehension was specific to the type of stimuli (words vs. pictures vs. words and pictures) used to probe the comprehension of objects and actions (Bak & Hodges, 2003;Bak et al, 2006;d'Honincthun & Pillon, 2008). For example, in Bak and Hodges's (2003) study, a group of patients with semantic dementia showed a disproportionate impairment with nouns compared to verbs in a semantic association task (Pyramids and Palm Trees Test, Howard & Patterson, 1992;Kissing and Dancing Test, Bak & Hodges, 2003) when the items were presented as written words but did not show any noun/ verb dissociation when the same items were probed with pictures of objects and actions.…”

Section: Patterns Of Grammatical Category-specific Deficits Inconsistmentioning

confidence: 96%

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The organization of the conceptual system: The case of the “object versus action” dimension

Pillon

d’Honincthun

2010

Cognitive Neuropsychology

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There are very numerous reports in the neuropsychological literature of patients showing, in naming and/or comprehension tasks, a disproportionate deficit for nouns in comparison with verbs or a disproportionate deficit for verbs in comparison with nouns. A number of authors advanced that, in at least some or even in every of these reported cases, the noun/verb dissociation in fact reflected an underlying conceptual deficit disproportionately affecting either object or action concepts. These patterns thus would put an additional constraint on theories of conceptual knowledge organization, which should be able to explain how brain damage could selectively disrupt the concepts of objects or the concepts of actions. We have reviewed 69 papers (published from 1984 to 2009) that reported a pattern of a noun or a verb disproportionate deficit in a single-case, multiple-case, or group study of brain-damaged patients with various aetiologies. From this review, we concluded that none of these studies provided compelling evidence in favour of the interpretation that the observed noun or verb disproportionate deficit arose at the conceptual processing level and, accordingly, that this level may be organized according to the "object/action" dimension. Furthermore, we argue that investigating conceptual impairments in brain-damaged patients according to the "object/action" dichotomy is not empirically fruitful if the purpose is to inform theories of conceptual knowledge organization. In order to provide evidence relevant to these theories, one needs to consider finer grained distinctions within both the object and the action category when investigating the scope of the patients' conceptual impairment.

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Verb comprehension and naming in frontotemporal degeneration: The role of the static depiction of actions

Cited by 43 publications

References 37 publications

Words in motion: Motor-language coupling in Parkinson’s disease

Words in motion: Motor-language coupling in Parkinson’s disease

Language, executive function and social cognition in the diagnosis of frontotemporal dementia syndromes

The organization of the conceptual system: The case of the “object versus action” dimension

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