Verbal and non-verbal memory and hippocampal volumes in a memory clinic population

Bonner‐Jackson, Aaron; Mahmoud, Safaa Rashad; Miller, Justin B.; Banks, Sarah J.

doi:10.1186/s13195-015-0147-9

Cited by 111 publications

(88 citation statements)

References 45 publications

(47 reference statements)

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“…Similarly, this pattern of diffusion metric changes was correlated with executive functioning z ‐scores, but only within the corpus callosum genu, reflecting the frontal lobe localization of the executive functioning testing used in the current study . Although only left hippocampal MD changes were selectively significantly correlated with memory z ‐scores, with a trend for right hippocampal MD metrics, this is consistent with working memory localization to the hippocampus . It is likely that the right hippocampal metrics did not reach significance due to the relative small sample size included in the study.…”

Section: Discussionsupporting

confidence: 53%

Patients with Mild Cognitive Impairment May be Stratified by Advanced Diffusion Metrics and Neurocognitive Testing

Allen

Yazdani

Kang

et al. 2018

Journal of Neuroimaging

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BACKGROUND AND PURPOSE Mild cognitive impairment (MCI) is a prevalent disorder, with a subset of patients progressing to dementia each year. Although MCI may be subdivided into amnestic or vascular types as well as into single or multiple cognitive domain involvement, most prior studies using advanced diffusion imaging have not accounted for these categories. The purpose of the current study was to determine if the pattern of diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) metrics in patients with amnestic MCI (aMCI) correlate to specific cognitive domain impairments. METHODS Nineteen consecutive patients with aMCI referred for brain magnetic resonance imaging (MRI) were included. All subjects underwent neurocognitive testing. A z‐score was calculated for each domain and a composite of all four domains. Brain MRI included standard structural imaging and diffusion imaging. Volumetric, DTI, and DKI metrics were calculated and statistical analysis was performed with adjustments for multiple measures and comparisons. RESULTS Statistically significant correlations between diffusion metrics and cognitive z‐scores were detected: visuospatial‐visuoconstructional z‐scores only correlated with alterations in the corpus callosum splenium, executive functioning z‐scores with the corpus callosum genu, memory testing z‐scores with the left hippocampus, and composite z‐scores with the anterior centrum semiovale. CONCLUSION Neuroimaging studies of patients with aMCI to date have assumed a population with homogeneous cognitive impairment. Our results demonstrate selective patterns of regional diffusion metric alterations correlate to specific cognitive domain impairments. Future studies should account for this heterogeneity, and this may also be useful for prognostication.

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Section: Discussionsupporting

confidence: 53%

Patients with Mild Cognitive Impairment May be Stratified by Advanced Diffusion Metrics and Neurocognitive Testing

Allen

Yazdani

Kang

et al. 2018

Journal of Neuroimaging

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“…Others, using verbal EM measures have also failed to find an association (Pereira et al, 2007; Thomas et al, 2016). Hence, spatial memory tasks could be more sensitive to structural changes in hippocampus (Bonner-Jackson et al, 2015). …”

Section: Discussionmentioning

confidence: 99%

Aerobic Exercise Intervention, Cognitive Performance, and Brain Structure: Results from the Physical Influences on Brain in Aging (PHIBRA) Study

Jonasson

Nyberg

Kramer

et al. 2017

Front. Aging Neurosci.

168

172

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Studies have shown that aerobic exercise has the potential to improve cognition and reduce brain atrophy in older adults. However, the literature is equivocal with regards to the specificity or generality of these effects. To this end, we report results on cognitive function and brain structure from a 6-month training intervention with 60 sedentary adults (64–78 years) randomized to either aerobic training or stretching and toning control training. Cognitive functions were assessed with a neuropsychological test battery in which cognitive constructs were measured using several different tests. Freesurfer was used to estimate cortical thickness in frontal regions and hippocampus volume. Results showed that aerobic exercisers, compared to controls, exhibited a broad, rather than specific, improvement in cognition as indexed by a higher “Cognitive score,” a composite including episodic memory, processing speed, updating, and executive function tasks (p = 0.01). There were no group differences in cortical thickness, but additional analyses revealed that aerobic fitness at baseline was specifically related to larger thickness in dorsolateral prefrontal cortex (dlPFC), and hippocampus volume was positively associated with increased aerobic fitness over time. Moreover, “Cognitive score” was related to dlPFC thickness at baseline, but changes in “Cognitive score” and dlPFC thickness were associated over time in the aerobic group only. However, aerobic fitness did not predict dlPFC change, despite the improvement in “Cognitive score” in aerobic exercisers. Our interpretation of these observations is that potential exercise-induced changes in thickness are slow, and may be undetectable within 6-months, in contrast to change in hippocampus volume which in fact was predicted by the change in aerobic fitness. To conclude, our results add to a growing literature suggesting that aerobic exercise has a broad influence on cognitive functioning, which may aid in explaining why studies focusing on a narrower range of functions have sometimes reported mixed results.

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“…Although a "classical" view indicates that the left hippocampus would be mainly involved in verbal memory processes (as opposed to the right hippocampus, inolved instead mainly in visuospatial memory processes), recent evidence found instead no evidence of such lateralisation [69]. On this note, the creation of a memory composite score based on both verbal and visuospatial memory performance would be a better modality-independent estimate of real mnemonic capacities, as it is a value obtained averaging four and not simply two values.…”

Section: Discussionmentioning

confidence: 98%

ApoE ε4 Allele Related Alterations in Hippocampal Connectivity in Early Alzheimer’s Disease Support Memory Performance

Marco

Vallelunga

Meneghello

et al. 2017

CAR

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Verbal and non-verbal memory and hippocampal volumes in a memory clinic population

Cited by 111 publications

References 45 publications

Patients with Mild Cognitive Impairment May be Stratified by Advanced Diffusion Metrics and Neurocognitive Testing

Patients with Mild Cognitive Impairment May be Stratified by Advanced Diffusion Metrics and Neurocognitive Testing

Aerobic Exercise Intervention, Cognitive Performance, and Brain Structure: Results from the Physical Influences on Brain in Aging (PHIBRA) Study

ApoE ε4 Allele Related Alterations in Hippocampal Connectivity in Early Alzheimer’s Disease Support Memory Performance

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