Verhandeln in Briefen

Bastian, Corina

doi:10.7788/boehlau.9783412211820

Cited by 12 publications

(2 citation statements)

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“…[44][45][46][47][48] In contrast, a more facile introduction of functionalities in structurally complex molecules generally depends on non-covalent protecting group strategies 49,50 and enzymatic approaches. 51 In patent WO 2013/191550 A1, 43 a novel one-step regioselective chemical diazotation of the C3-amine functionality of the 2-DOS ring is presented (Fig. 2A).…”

Section: Aminoglycosides As Antibacterial Agentsmentioning

confidence: 99%

A review of patents (2011–2015) towards combating resistance to and toxicity of aminoglycosides

Chandrika

Garneau‐Tsodikova

2016

Med. Chem. Commun.

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Since the discovery of the first aminoglycoside (AG), streptomycin, in 1943, these broad-spectrum antibiotics have been extensively used for the treatment of Gram-negative and Gram-positive bacterial infections. The inherent toxicity (ototoxicity and nephrotoxicity) associated with their long-term use as well as the emergence of resistant bacterial strains have limited their usage. Structural modifications of AGs by AG-modifying enzymes, reduced target affinity caused by ribosomal modification, and decrease in their cellular concentration by efflux pumps have resulted in resistance towards AGs. However, the last decade has seen a renewed interest among the scientific community for AGs as exemplified by the recent influx of scientific articles and patents on their therapeutic use. In this review, we use a non-conventional approach to put forth this renaissance on AG development/application by summarizing all patents filed on AGs from 2011–2015 and highlighting some related publications on the most recent work done on AGs to overcome resistance and improving their therapeutic use while reducing ototoxicity and nephrotoxicity. We also present work towards developing amphiphilic AGs for use as fungicides as well as that towards repurposing existing AGs for potential newer applications.

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Section: Aminoglycosides As Antibacterial Agentsmentioning

confidence: 99%

A review of patents (2011–2015) towards combating resistance to and toxicity of aminoglycosides

Chandrika

Garneau‐Tsodikova

2016

Med. Chem. Commun.

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“…In a reverse approach, the regioselective diazotation of aminoglycosides has been investigated, because such route could offer a fast and simple access to valuable building blocks [77].…”

Section: 2 Modification At Positionmentioning

confidence: 99%

Targeted modifications of neomycin and paromomycin: Towards resistance-free antibiotics?

Obszynski

Loidon

Blanc

et al. 2022

Bioorganic Chemistry

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Feminist Knowledge Production in Europe on Diplomacy and International Negotiation

Kostadinova

2022

Feminist IR in Europe

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This chapter traces the development of feminist scholarship in Europe on diplomacy and international negotiation. Sensitive to variations between different national contexts, this chapter suggests that the state frames the broader socio-political environment, which incentivizes or discourages the creation of feminist knowledge. This chapter also provides important insights on prevailing silences and limitations of existing research. By outlining both the thematic and the geographical discrepancies in feminist knowledge production on diplomacy across Europe, this chapter calls attention to the systematic disregard of gender as a category of analysis in many European countries and offers useful avenues for further research.

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Verhandeln in Briefen

Cited by 12 publications

References 0 publications

A review of patents (2011–2015) towards combating resistance to and toxicity of aminoglycosides

A review of patents (2011–2015) towards combating resistance to and toxicity of aminoglycosides

Targeted modifications of neomycin and paromomycin: Towards resistance-free antibiotics?

Feminist Knowledge Production in Europe on Diplomacy and International Negotiation

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