Vernal Keratoconjunctivitis and Severe Keratoconus Associated with Autoimmune Polyglandular Syndrome Type II ( APS-2 ) : A Case Report

Alhawari, Hussam; Bdour, Muawyah

doi:10.12816/0033485

Cited by 2 publications

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The association between autoimmune diseases and KC has been suggested based on retrospective studies and case reports [ 20 – 24 ]. A recent study showed a prevalence of thyroid gland dysfunction of 13.6% in patients with KC [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Autoimmune Thyroid Disease and Keratoconus: Is There an Association?

Alhawari

Khader

Al‐Omari

et al. 2018

International Journal of Endocrinology

Self Cite

View full text Add to dashboard Cite

Purpose The association between autoimmune diseases and keratoconus (KC) has been proposed based on previous retrospective studies and case reports. The aim of our study is to investigate whether KC is associated with autoimmune thyroid disease. Methods. A comparative study was conducted on 131 adult subjects from September 2015 to May 2017 at Jordan University Hospital, Amman, Jordan. Subjects were classified into 2 groups: subjects with autoimmune thyroid disease, including Graves' disease and Hashimoto's thyroiditis (n = 68), and a healthy group for comparison (n = 63). Subjects with any other conditions known to be associated with KC were excluded. The diagnosis of KC was based on clinical and corneal topographic findings utilizing the Oculus-Pentacam machine. In addition, TSH and total T4 levels as well as thyroid peroxidase antibodies were measured in all study participants. Antithyroglobulin antibodies, thyroid stimulating immunoglobulin, thyroid ultrasound, and thyroid uptake and scan were also selectively performed in some participants. Results This study included a total of 131 participants (101 females and 30 males), including patients and controls. In the multivariate analysis, autoimmune disease was not significantly associated with keratoconus (OR = 1.1; 95% confidence interval: 0.3, 3.8; p value = 0.353) after adjusting for age and gender. Conclusion This study did not show a statistically significant association between autoimmune thyroid disease and KC.

show abstract

Section: Introductionmentioning

confidence: 99%

Autoimmune Thyroid Disease and Keratoconus: Is There an Association?

Alhawari

Khader

Al‐Omari

et al. 2018

International Journal of Endocrinology

Self Cite

View full text Add to dashboard Cite

show abstract

Corneal Tomographic Analysis Among Patients With Thyroid Gland Dysfunction

Bassiouny¹,

Awad²,

Gaafar³

et al. 2021

J Refract Surg

View full text Add to dashboard Cite

PURPOSE: To analyze the corneal tomographic parameters of patients with thyroid gland dysfunction. METHODS: This case–control study included 100 eyes of 50 patients with thyroid gland dysfunction and 100 eyes of 50 healthy controls. All eyes were examined by Pentacam (Oculus Optikgeräte GmbH). Pentacam parameters were compared between patients with thyroid gland dysfunction and controls. Spearman's correlation coefficient between different Pentacam parameters and the serum level of free thyroxin (T4) and thyroid-stimulating hormone (TSH) was calculated. RESULTS: Patients with hypothyroidism had significantly higher median values of steep and maximum simulated keratometric readings, central corneal thickness (CCT), and thinnest pachymetry (CTmin) than both patients with hyperthyroidism and controls ( P ⩽ .05). The median values of the average and maximum pachymetric progression index (PPI), posterior elevation, and back difference elevation were significantly higher in patients with hyperthyroidism than in patients with hypothyroidism and controls ( P ⩽ .05). The Ambrósio Relational Thickness (ARTmax) was significantly reduced in patients with hyperthyroidism ( P ⩽ .001). Both CCT and CTmin showed a moderately positive correlation with serum TSH level and a moderately negative correlation with serum free T4 level. Patients with non-autoimmune thyroid gland dysfunction had significantly thinner CCT, CTmin, and inferior vertical deviation than the autoimmune group ( P ⩽ .05). CONCLUSIONS: Thyroid gland dysfunction is associated with significant corneal tomographic changes. Patients with hyperthyroidism tend to have thinner corneas and more abnormal tomographic parameters correlating with keratoconus. No significant tomographic changes were found in association with autoimmune thyroid gland dysfunction. The authors recommend screening and regular follow-up of patients with thyroid gland dysfunction for early detection and management of keratoconus. [ J Refract Surg . 2021;37(3):192–197.]

show abstract

Vernal Keratoconjunctivitis and Severe Keratoconus Associated with Autoimmune Polyglandular Syndrome Type II ( APS-2 ) : A Case Report

Cited by 2 publications

References 9 publications

Autoimmune Thyroid Disease and Keratoconus: Is There an Association?

Autoimmune Thyroid Disease and Keratoconus: Is There an Association?

Corneal Tomographic Analysis Among Patients With Thyroid Gland Dysfunction

Contact Info

Product

Resources

About