2024
DOI: 10.21203/rs.3.rs-4182910/v1
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Versatile, accessible cross-platform molecular profiling of central nervous system tumors: web-based, prospective multi-center validation

Felix Sahm,
Areeba Patel,
Kirsten Göbel
et al.

Abstract: The 2021 WHO classification underscores the importance of molecular data integration in Central Nervous System (CNS) tumor diagnostics. However, currently used assays have disadvantages due to technical complexity, required equipment and reagent cost, as well as lengthy turnaround times. In response to these challenges, we introduce Rapid-CNS2 and MNP-Flex. Rapid-CNS2, an adaptive sampling-based nanopore sequencing workflow, offers real-time methylation classification and DNA copy-number information within a 3… Show more

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