Versatile Hydrogel Dressing with Skin Adaptiveness and Mild Photothermal Antibacterial Activity for Methicillin‐Resistant Staphylococcus Aureus‐Infected Dynamic Wound Healing

Abstract

Bacterial infection often induces chronic repair of wound healing owing to aggravated inflammation. Hydrogel dressing exhibiting intrinsic antibacterial activity may substantially reduce the use of antibiotics for infected wound management. Hence, a versatile hydrogel dressing (rGB/QCS/PDA–PAM) exhibiting skin adaptiveness on dynamic wounds and mild photothermal antibacterial activity is developed for safe and efficient infected wound treatment. Phenylboronic acid‐functionalized graphene (rGB) and oxadiazole‐decorated quaternary carboxymethyl chitosan (QCS) are incorporated into a polydopamine–polyacrylamide (PDA–PAM) network with multiple covalent and noncovalent bonds, which conferred the hydrogel with flexible mechanical properties, strong tissue adhesion and excellent self‐healing ability on the dynamic wounds. Moreover, the glycocalyx‐mimicking phenylboronic acid on the surface of rGB enables the hydrogel to specifically capture bacteria. The enhanced membrane permeability of QCS enhanced bacterial vulnerability to photothermal therapy（PTT）, which is demonstrated by efficient mild PTT antibacteria against methicillin‐resistant Staphylococcus aureus in vitro and in vivo at temperatures of <49.6 °C. Consequently, the hydrogel demonstrate accelerated tissue regeneration on MRSA‐infected wound in vivo, with an intact epidermis, abundant collagen deposition and prominent angiogenesis. Therefore, rGB/QCS/PDA–PAM is a versatile hydrogel dressing exhibiting inherent antibacterial activity and has considerable potential in treating wounds infected with drug‐resistant bacteria.

Photothermal synergistic nitric oxide controlled release injectable self-healing adhesive hydrogel for biofilm eradication and wound healing

“…Phenylboronic acid is considered as a glycocalyx-mimicking molecule that binds specifically to diol-containing saccharides on microorganism surfaces via boronic acid-diol formation. 48 QCS conjugated with phenylboronic acid moieties can specifically capture abundant bacteria causing contact damage of bacterial plasma membranes by QCS, thereby making them more susceptible to mild photothermal and NO therapy, and the synthetic route of QCS-PBA is shown in Fig. S7 (ESI†).…”

“…S16, ESI†), which enabled its potential application for m-PTT ( T < 50 °C). 48 Thus, the QP/QT-MB hydrogel incorporated with 0.2 mg mL −1 MPDA@BNN6 was selected for subsequent investigation.…”

“…, amines, thiols, and amide bonds) on the wet tissue, and cause the robust wet adhesion desired for the wound microenvironment. 48 Moreover, the adhesion strength of the hydrogels depends on both the interfacial adhesiveness and the cohesion of hydrogels. Compared to QP/QT, the QP/QT-M and QP/QT-MB hydrogel possessed an improved tissue adhesion ability, which should be attributed to the introduction of MPDA NPs, that not only increased the catechol moieties, but could also form a second borate ester-based cross-linked network with the hydrogel backbone (QCS-PBA), resulting in enhanced cohesive forces and interfacial adhesion.…”

Fabrication of Chitosan-Based Hydrogel Embedded with Antibacterial AgMXene Nanocomposites as Photothermal Centers for Solar Steam Generation and Purification

“…Conversely, the self-cleaning characteristics of AM/CH are likely ascribed to chitosan that possesses inherent bactericidal capabilities stemming from plentiful positive amino groups (NH 2 ). These groups are capable of engaging in electrostatic interactions with negatively charged pathogens, thereby causing the demise of such microorganisms …”

“…These groups are capable of engaging in electrostatic interactions with negatively charged pathogens, thereby causing the demise of such microorganisms. 50…”