Versatile nanodiamond-based tools for therapeutics and bioimaging

Leung, Hoi Man; Chu, Hoi Ching; Mao, Zhengwei; Lo, Pik Kwan

doi:10.1039/d2cc06495b

Cited by 14 publications

(7 citation statements)

References 195 publications

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“…The use of microorganisms or plant extracts to synthesize nanoparticles allows for obtaining nanoparticles with high biocompatibility. Recent research showed that nanoparticles synthesized by such green synthesis methods have surfaces coated with proteins, fibers, and carbohydrates that provide them greater biocompatibility than those of the same size and shape but synthesized using chemical methods [ 38 , 39 ].…”

Section: Nanoparticle Toxicitymentioning

confidence: 99%

Experimental Methods for the Biological Evaluation of Nanoparticle-Based Drug Delivery Risks

et al. 2023

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Many novel medical therapies use nanoparticle-based drug delivery systems, including nanomaterials through drug delivery systems, diagnostics, or physiologically active medicinal products. The approval of nanoparticles with advanced therapeutic and diagnostic potentials for applications in medication and immunization depends strongly on their synthesizing procedure, efficiency of functionalization, and biological safety and biocompatibility. Nanoparticle biodistribution, absorption, bioavailability, passage across biological barriers, and biodistribution are frequently assessed using bespoke and biological models. These methods largely rely on in vitro cell-based evaluations that cannot predict the complexity involved in preclinical and clinical studies. Therefore, assessing the nanoparticle risk has to involve pharmacokinetics, organ toxicity, and drug interactions manifested at multiple cellular levels. At the same time, there is a need for novel approaches to examine nanoparticle safety risks due to increased constraints on animal exploitation and the demand for high-throughput testing. We focus here on biological evaluation methodologies that provide access to nanoparticle interactions with the organism (positive or negative via toxicity). This work aimed to provide a perception regarding the risks associated with the utilization of nanoparticle-based formulations with a particular focus on assays applied to assess the cytotoxicity of nanomaterials.

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Section: Nanoparticle Toxicitymentioning

confidence: 99%

Experimental Methods for the Biological Evaluation of Nanoparticle-Based Drug Delivery Risks

et al. 2023

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“…20 Surface chemical modication of NDs has been extensively investigated, primarily to address colloidal stability, biocompatibility, and interaction with surrounding tissues. [15][16][17] These properties, combined with high photostability, lead to wide applications of NDs in biomedicine, [11][12][13][14][15][16][17] including drug delivery and long-term cell tracking. 21 For example, carboxyl groups on the surface of NDs were modied with poly(ethylene glycol) (PEG) and subsequent physisorption of doxorubicin (DOX), achieving higher drug loading and increased drug efficacy.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, nanodiamonds (NDs) have emerged as excellent candidates for bioimaging, biosensing and drug delivery. 11–17 This can be attributed to the excellent properties offered by NDs such as high photostability (nearly quantitative yield), excellent biocompatibility, high chemical stability and great thermal conductivity. 11–13…”

Section: Introductionmentioning

confidence: 99%

Modification of nanodiamonds for fluorescence bioimaging

Fryer,

Murray,

Zhang

2024

RSC Adv.

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“…Nanodiamonds are another/important class of biomaterial primarily made of interlinked tetrahedral of sp 3 hybridized carbon. Nanodiamonds have various applications in electronic sensor, functional coating, bioimaging, drug delivery, and tissue engineering . Nanodiamonds are usually synthesized by detonation, high pressure high temperature, and chemical vapor deposition methods …”

Section: Introductionmentioning

confidence: 99%

Potential Use of Nucleic Acids as a Preceramic Polymer to Synthesize Nanodiamond-Embedded Phosphate Glass for Hard Tissue Engineering

Tripathy

Gupta

Nayak

et al. 2023

ACS Appl. Bio Mater.

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In recent years, nucleic acid has emerged as a versatile molecule that has been strategically used in material synthesis and biomedical applications. Keeping in mind the presence of the phosphate group, a glass former in the nucleic acids, we synthesized a transparent glass-like material by the thermal treatment of nucleic acids (DNA and RNA) at 900 °C at atmospheric pressure. Characterization of this material by transmission electron microscopy, X-ray photoelectron spectroscopy, and confocal fluorescence microscopy suggested the presence of in situ-formed nanodiamonds within the phosphate glass matrix. The molecular structure of glass investigated by X-ray photoelectron and infrared spectroscopy indicated a nearly equal proportion of metaphosphates and smaller phosphate units (pyro-and orthophosphate) that form the phosphate glass matrix. Thereafter, in vitro biological experiments showed that the nucleic acid-derived glass was non-toxic and cytocompatible, enhanced extracellular matrix secretion, and increased intracellular alkaline phosphatase activity, with potential application in hard tissue engineering. Our work offers insights into nanodiamond synthesis at atmospheric pressure and proves that nucleic acids could be used as a precursor to making an innovative glass-ceramic biomaterial.

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Versatile nanodiamond-based tools for therapeutics and bioimaging

Abstract: Nanodiamonds (NDs) are a remarkable class of carbon-based nanoparticles in nanomedicine which have recently become a hot topic of research due to their unique features including functionalization versatility, tunable opto-magnetic...

Cited by 14 publications

References 195 publications

Experimental Methods for the Biological Evaluation of Nanoparticle-Based Drug Delivery Risks

Experimental Methods for the Biological Evaluation of Nanoparticle-Based Drug Delivery Risks

Modification of nanodiamonds for fluorescence bioimaging

Potential Use of Nucleic Acids as a Preceramic Polymer to Synthesize Nanodiamond-Embedded Phosphate Glass for Hard Tissue Engineering

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