Versatile Strategy for the Chemoenzymatic Synthesis of Branched Human Milk Oligosaccharides Containing the Lacto‐N‐Biose Motif
Hsin‐Kai Tseng,
Ting‐Yi Lee,
Yu‐Ching Chiang
et al.
Abstract:Human milk oligosaccharides (HMOs) exhibit prebiotic, antimicrobial, and immunomodulatory properties and confer significant benefits to infants. Branched HMOs are constructed through diverse glycosidic linkages and prominently feature the lacto‐N‐biose (LNB, Gal‐β1,3‐GlcNAc) motif with fucose and/or sialic acid modifications, displaying structural complexity that surpasses that of N‐ and O‐glycans. However, synthesizing comprehensive libraries of branched HMO is challenging due to this complexity. Although a f… Show more
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