Versicotides D–F, new cyclopeptides with lipid-lowering activities

Chen, Ran; Cheng, Zhongbin; Huang, Jian; Liu, Dong; Wu, Chongming; Guo, Peng; Lin, Wenhan

doi:10.1039/c7ra07940k

Cited by 25 publications

(29 citation statements)

References 24 publications

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“…][ In the present work, a soft coral associated fungal strain Aspergillus versicolor LZD‐44‐03, was examined by the NMR and MS spectra. The spectroscopic data revealed that the fermented extract contains unknown metabolites in comparison with the compounds obtained from the different strains of the same fungal species what we reported previously …”

Section: Introductionsupporting

confidence: 65%

Varicuothiols A and B, New Fungal Metabolites from Aspergillus versicolor with Anti‐Inflammatory Activities

Chen

Liu

Guo

et al. 2017

Chemistry & Biodiversity

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Chemical examination of a coral-associated fungus Aspergillus versicolor LZD-44-03 resulted in the isolation of two new compounds with the trivial names of varicuothiols A (1) and B (2) as a unique scaffold. Their structures were determined through extensive spectroscopic analyses in association with the modified Mosher's method and chemical conversion. Both 1 and 2 exhibited significant inhibition against LPS-induced RAW24.7 cell proliferation, in association with the down regulation of nitrite production and cytokines (MCP-1, IL-6, and TNF-a).

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Section: Introductionsupporting

confidence: 65%

Varicuothiols A and B, New Fungal Metabolites from Aspergillus versicolor with Anti‐Inflammatory Activities

Chen

Liu

Guo

et al. 2017

Chemistry & Biodiversity

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“…Versicotides E and F possessed very rare structures that have two anthranilic acid residues and a proline in a single cyclic peptide system. They showed significant lipid-lowering activities by regulating cholesterol efflux and influx [58]. Chemical investigation on the culture extracts of mangrove-derived fungus Sarocladium kiliense HDN11-112 led to the discovery of two new cyclic depsipeptides saroclides A ( 127 ) and B ( 128 ).…”

Section: Peptidesmentioning

confidence: 99%

Bioactive Compounds Isolated from Marine-Derived Microbes in China: 2009–2018

Sun

et al. 2019

Marine Drugs

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This review outlines the research that was carried out regarding the isolation of bioactive compounds from marine-derived bacteria and fungi by China-based research groups from 2009–2018, with 897 publications being surveyed. Endophytic organisms featured heavily, with endophytes from mangroves, marine invertebrates, and marine algae making up more than 60% of the microbial strains investigated. There was also a strong focus on fungi as a source of active compounds, with 80% of publications focusing on this area. The rapid increase in the number of publications in the field is perhaps most notable, which have increased more than sevenfold over the past decade, and suggests that China-based researchers will play a major role in marine microbial natural products drug discovery in years to come.

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“…11 Later, the same group employed the OSMAC (one strain many compounds) approach on this fungus, resulting in the isolation and characterization of a new compound with structural similarities named versicotide C (3), 12 the rst natural cyclic hexapeptide containing two anthranilic acids (Anth). Further on, three new cyclopeptides were isolated from Aspergillus versicolor LZD-14-1 namely versicotides D-F, 13 along with the previously known versicotides A and B.…”

Section: Introductionmentioning

confidence: 98%

“…The structures of the obtained compounds were conrmed by MS, NMR and, in the case of versicotide A (1), by X-ray analysis. A deep analysis of NMR data ( 1 H, 13 C, COSY, HSQC and HMBC) was done in order to determine the adopted conformations in the used solvents, along with temperature variation studies.…”

Section: Introductionmentioning

confidence: 99%