Vesicle‐associated protein‐A is differentially expressed during intestinal smooth muscle cell differentiation

Gabetta, Vijayalakshmi; Trzyna, Wendy; Phiel, Christopher J.; McHugh, Kirk M.

doi:10.1002/dvdy.10349

Cited by 3 publications

(3 citation statements)

References 39 publications

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“…VAP proteins are ubiquitously expressed in mammals ( Weir et al, 1998 ; Nishimura et al, 1999 ; Skehel et al, 2000 ), with tissue-specific RNA expression patterns during development ( Gabetta et al, 2003 ). They interact with a wide variety of proteins, imparting them with various functions, including organelle membrane tethering ( Costello et al, 2017a ), lipid transfer between organelles ( Kawano et al, 2006 ; Ngo and Ridgway, 2009 ), regulation of calcium homeostasis ( De Vos et al, 2012 ; Lindhout et al, 2019 ), autophagy ( Zhao et al, 2018 ) and the unfolded protein response (UPR) ( Kanekura et al, 2006 ; Gkogkas et al, 2008 ).…”

Section: Introductionmentioning

confidence: 99%

VAP Proteins – From Organelle Tethers to Pathogenic Host Interactors and Their Role in Neuronal Disease

Kors

Costello

Schrader

2022

Front. Cell Dev. Biol.

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Vesicle-associated membrane protein (VAMP)-associated proteins (VAPs) are ubiquitous ER-resident tail-anchored membrane proteins in eukaryotic cells. Their N-terminal major sperm protein (MSP) domain faces the cytosol and allows them to interact with a wide variety of cellular proteins. Therefore, VAP proteins are vital to many cellular processes, including organelle membrane tethering, lipid transfer, autophagy, ion homeostasis and viral defence. Here, we provide a timely overview of the increasing number of VAPA/B binding partners and discuss the role of VAPA/B in maintaining organelle-ER interactions and cooperation. Furthermore, we address how viruses and intracellular bacteria hijack VAPs and their binding partners to induce interactions between the host ER and pathogen-containing compartments and support pathogen replication. Finally, we focus on the role of VAP in human disease and discuss how mutated VAPB leads to the disruption of cellular homeostasis and causes amyotrophic lateral sclerosis.

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Section: Introductionmentioning

confidence: 99%

VAP Proteins – From Organelle Tethers to Pathogenic Host Interactors and Their Role in Neuronal Disease

Kors

Costello

Schrader

2022

Front. Cell Dev. Biol.

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“…VAP proteins are ubiquitously expressed in mammals (Weir et al, 1998;Nishimura et al, 1999;Skehel et al, 2000), with tissuespecific RNA expression patterns during development (Gabetta et al, 2003). They interact with a wide variety of proteins, imparting them with various functions, including organelle membrane tethering , lipid transfer between organelles (Kawano et al, 2006;Ngo and Ridgway, 2009), regulation of calcium homeostasis (De Vos et al, 2012;Lindhout et al, 2019), autophagy (Zhao et al, 2018) and the unfolded protein response (UPR) (Kanekura et al, 2006;Gkogkas et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Molecular Mechanisms and Physiological Significance of Organelle Interactions and Cooperation - Volume II

2022

Frontiers Research Topics

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Frontiers is more than just an open-access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers Journal SeriesThe Frontiers Journal Series is a multi-tier and interdisciplinary set of open-access, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers Journal Series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to QualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation.

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“…Smooth muscle cells play a major role in diseases like cancer, asthma, arteriosclerosis, and hypertension since they constitute the main layer of smooth muscle tissues [9,11]. Gastrointestinal smooth muscle diseases represent a major health problem affecting 2 million individuals every year [12]. Smooth muscle cell regeneration is required in the gastrointestinal tract as defects commonly occur [13].…”

Section: Introductionmentioning

confidence: 99%

Low Intensity Laser Irradiation and Growth Factors Influence Differentiation of Adipose Derived Stem Cells into Smooth Muscle Cells in a Coculture Environment over a Period of 72 Hours

Mvula

Abrahamse

2014

International Journal of Photoenergy

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Stem cells have the ability to self-renew and differentiate into several specialised cells. Low intensity laser irradiation (LILI) has been shown to have positive effects on cells including adipose derived stem cells (ADSCs). Growth factors such as retinoic acid and transforming growth factor (TGF-β1) play significant roles in the differentiation of cells. This study aimed at investigating the role of LILI and growth factors on differentiation of adipose derived stem cells cocultured with smooth muscle cells (SMCs). The study used isolated human adipose derived stem cells and smooth muscle commercial cells (SKUT-1). The cells were cocultured directly in the ratio 1 : 1 using the established methods with and without growth factors (retinoic acid and TGF-β1) and then exposed to LILI at a wavelength of 636 nm with 5 J/cm2using a diode laser. The cellular proliferation and expression of the both cell type markers were assessed using optical density and flow cytometry at 24 h and 72 h. The study showed that LILI increased the proliferation of cocultured cells. The expression of the smooth muscle cell markers increased in the coculture groups that were exposed to LILI in the presence of growth factors while those of the ADSCs decreased.

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Vesicle‐associated protein‐A is differentially expressed during intestinal smooth muscle cell differentiation

Cited by 3 publications

References 39 publications

VAP Proteins – From Organelle Tethers to Pathogenic Host Interactors and Their Role in Neuronal Disease

VAP Proteins – From Organelle Tethers to Pathogenic Host Interactors and Their Role in Neuronal Disease

Molecular Mechanisms and Physiological Significance of Organelle Interactions and Cooperation - Volume II

Low Intensity Laser Irradiation and Growth Factors Influence Differentiation of Adipose Derived Stem Cells into Smooth Muscle Cells in a Coculture Environment over a Period of 72 Hours

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