Vessel Density in the Macular and Peripapillary Areas in Preperimetric Glaucoma to Various Stages of Primary Open-Angle Glaucoma in Taiwan

Ko, Chung-Kuang; Huang, Kuan-I; Su, Fang-Ying; Ko, Mei–Lan

doi:10.3390/jcm10235490

Cited by 6 publications

(5 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…26 In addition, reduced ONH VD has been observed in patients with glaucoma, diabetes mellitus, and subcortical vascular cognitive impairment. [27][28][29] There is limited research into changes in macular VD following COVID-19. 20,30,31 Some studies have reported ONH changes after COVID-19.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Optic nerve head alterations after COVID-19: an optical coherence tomography angiography-based longitudinal study

Abrishami,

Hassanpour,

Bayat

et al. 2024

J Int Med Res

View full text Add to dashboard Cite

Objective To evaluate longitudinal changes in peripapillary vessel density (VD) following coronavirus disease 2019 (COVID-19) using optical coherence tomography angiography. Methods As part of a prospective longitudinal observational study, we studied healthy individuals with a history of mild COVID-19 confirmed via real-time polymerase chain reaction. After recovery, we used the Optovue RTVue XR Avanti machine to perform optic nerve head (ONH) imaging. We also assessed the VD of all vessels and of small vessels in the disc and the radial peripapillary capillary (RPC) network at 1 and 3 months post-recovery. Results We included 17 patients (34 eyes; mean age: 36.9 ± 10.2 years, range: 24–62 years) who had recovered from COVID-19. No changes were observed in the ONH parameters. However, there was a noticeable trend of increased small vessel VD values in the RPC. These increases were significant for the peripapillary whole, superior hemifield, inferior-temporal, temporal-superior, and superior-temporal small vessels. Moreover, the evaluation of all vessel VD values in the RPC revealed a significant decrease in the inside disc and a significant increase in a grid-based inferior region. Conclusion COVID-19 may affect VD of the RPC in the ONH, and should be considered in ONH evaluations.

show abstract

Section: Discussionmentioning

confidence: 99%

“… 26 In addition, reduced ONH VD has been observed in patients with glaucoma, diabetes mellitus, and subcortical vascular cognitive impairment. 27 – 29 …”

Section: Discussionmentioning

confidence: 99%

Optic nerve head alterations after COVID-19: an optical coherence tomography angiography-based longitudinal study

Abrishami,

Hassanpour,

Bayat

et al. 2024

J Int Med Res

View full text Add to dashboard Cite

show abstract

“…The mean defect of visual field more than -2 dB would be considered as abnormal visual field. Our study team have built up a normal ground of OCT and OCTA for normal subjects with different axial length [ 18 ]. All glaucoma patients were followed more than 1 years and their collected data was confirmed by an experienced glaucoma specialist.…”

Section: Methodsmentioning

confidence: 99%

Use of multimodal dataset in AI for detecting glaucoma based on fundus photographs assessed with OCT: focus group study on high prevalence of myopia

Lim

et al. 2022

BMC Med Imaging

Self Cite

View full text Add to dashboard Cite

Background Glaucoma is one of the major causes of blindness; it is estimated that over 110 million people will be affected by glaucoma worldwide by 2040. Research on glaucoma detection using deep learning technology has been increasing, but the diagnosis of glaucoma in a large population with high incidence of myopia remains a challenge. This study aimed to provide a decision support system for the automatic detection of glaucoma using fundus images, which can be applied for general screening, especially in areas of high incidence of myopia. Methods A total of 1,155 fundus images were acquired from 667 individuals with a mean axial length of 25.60 ± 2.0 mm at the National Taiwan University Hospital, Hsinchu Br. These images were graded based on the findings of complete ophthalmology examinations, visual field test, and optical coherence tomography into three groups: normal (N, n = 596), pre-perimetric glaucoma (PPG, n = 66), and glaucoma (G, n = 493), and divided into a training-validation (N: 476, PPG: 55, G: 373) and test (N: 120, PPG: 11, G: 120) sets. A multimodal model with the Xception model as image feature extraction and machine learning algorithms [random forest (RF), support vector machine (SVM), dense neural network (DNN), and others] was applied. Results The Xception model classified the N, PPG, and G groups with 93.9% of the micro-average area under the receiver operating characteristic curve (AUROC) with tenfold cross-validation. Although normal and glaucoma sensitivity can reach 93.51% and 86.13% respectively, the PPG sensitivity was only 30.27%. The AUROC increased to 96.4% in the N + PPG and G groups. The multimodal model with the N + PPG and G groups showed that the AUROCs of RF, SVM, and DNN were 99.56%, 99.59%, and 99.10%, respectively; The N and PPG + G groups had less than 1% difference. The test set showed an overall 3%–5% less AUROC than the validation results. Conclusion The multimodal model had good AUROC while detecting glaucoma in a population with high incidence of myopia. The model shows the potential for general automatic screening and telemedicine, especially in Asia. Trial registration: The study was approved by the Institutional Review Board of the National Taiwan University Hospital, Hsinchu Branch (no. NTUHHCB 108-025-E).

show abstract

“…Changes leading to a reduced density and calibre of retinal blood vessels occur during glaucoma [1,[6][7][8]. Numerous studies using optical coherence tomography angiography (OCTA) have shown significant reductions in the flow density, flow index, and vessel density in the optic nerve head and macula in patients with glaucoma compared to controls, as well as the association between these parameters and changes in the visual field [6,[9][10][11][12]. Colour Doppler Imaging has demonstrated reduced velocities and an increased resistivity index in intraocular vessels in glaucoma patients [13].…”

Section: Introductionmentioning

confidence: 99%

Is Primary Open-Angle Glaucoma a Vascular Disease? Assessment of the Relationship between Retinal Arteriolar Morphology and Glaucoma Severity Using Adaptive Optics

Szewczuk,

Wawrzyniak,

Szaflik

et al. 2024

JCM

View full text Add to dashboard Cite

Background: Retinal vascular abnormalities may be associated with glaucomatous damage. Adaptive optics (AO) is a new technology that enables the analysis of retinal vasculature at the cellular level in vivo. The purpose of this study was to evaluate retinal arteriolar parameters using the rtx1 adaptive optics fundus camera (AO-FC) in patients with primary open-angle glaucoma (POAG) at different stages and to investigate the relationship between these parameters and changes in spectral-domain optical coherence tomography (SD-OCT) and perimetry. Methods: Parameters of the retinal supratemporal and infratemporal arterioles (wall thickness (WT), lumen diameter (LD), total diameter (TD), wall-to-lumen ratio (WLR), and cross-sectional area of the vascular wall (WCSA)) were analysed with the rtx1 in 111 POAG eyes, which were divided into three groups according to the severity of the disease, and 70 healthy eyes. The associations between RTX1 values and the cup-to-disk ratio, SD-OCT parameters, and visual field parameters were assessed. Results: Compared with the control group, the POAG groups showed significantly smaller TD and LD values (p < 0.05) and significantly higher WLR and WT values (p < 0.05) for the supratemporal and infratemporal arterioles. TD was significantly positively correlated with the retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC) (p < 0.05). LD was significantly positively correlated with the RNFL, GCC, and rim area (p < 0.05). The WLR was significantly negatively correlated with the RNFL, GCC, rim area, and MD (p < 0.05), while it was significantly positively correlated with the cup-to-disc ratio and PSD (p < 0.05). Conclusions: The results suggest that vascular dysfunction is present in POAG, even at a very early stage of glaucoma, and increases with the severity of the disease.

show abstract

Vessel Density in the Macular and Peripapillary Areas in Preperimetric Glaucoma to Various Stages of Primary Open-Angle Glaucoma in Taiwan

Cited by 6 publications

References 46 publications

Optic nerve head alterations after COVID-19: an optical coherence tomography angiography-based longitudinal study

Optic nerve head alterations after COVID-19: an optical coherence tomography angiography-based longitudinal study

Use of multimodal dataset in AI for detecting glaucoma based on fundus photographs assessed with OCT: focus group study on high prevalence of myopia

Is Primary Open-Angle Glaucoma a Vascular Disease? Assessment of the Relationship between Retinal Arteriolar Morphology and Glaucoma Severity Using Adaptive Optics

Contact Info

Product

Resources

About