Vestibular function in Lermoyez syndrome at attack

Manzari, Leonardo; Burgess, Ann M.; Curthoys, Ian S.

doi:10.1007/s00405-011-1657-0

Cited by 20 publications

(6 citation statements)

References 17 publications

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“…Video‐oculography (VOG) allows easy, objective clinical assessment of the VOR 10–12 in the horizontal and vertical planes (see Figs. 1 and 3).…”

Section: Vvor With Video‐oculographymentioning

confidence: 99%

“…The characteristic clinical sign—the VVOR deficit—is usually simple to elicit and in most patients, special investigations are not required. The deficit in the VVOR and in the VOR can now be easily identified, documented, and measured with video‐oculography (VOG) 10–12 . Diagnosing CANVAS correctly and differentiating it from similar but more aggressive acquired (e.g., multiple system atrophy of cerebellar type [MSA C ] or Creutzfeldt‐Jakob disease with cerebellar impairment) and inherited diseases (e.g., Machado‐Joseph disease/spinocerebellar ataxia type 3 [SCA 3]) is important for patient management.…”

Section: Introductionmentioning

confidence: 99%

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Cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS): a review of the clinical features and video‐oculographic diagnosis

Szmulewicz

Waterston

MacDougall

et al. 2011

Annals of the New York Academy of Sciences

140

112

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The association of bilateral vestibulopathy with cerebellar ataxia was first reported in 1991 and delineated as a distinct syndrome with a characteristic and measurable clinical sign--an absent visually enhanced vestibulo-ocular reflex--in 2004. We reviewed 27 patients with this syndrome and show that a non-length-dependent sensory deficit with absent sensory nerve action potentials is an integral component of this syndrome, which we now call "cerebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome" (CANVAS). All patients had brain MRI and 22/27 had evidence of cerebellar atrophy involving anterior and dorsal vermis, as well as the hemispheric crus I. Brain and temporal bone pathology in one patient showed marked loss of Purkinje cells and of vestibular, trigeminal, and facial ganglion cells, but not of spiral ganglion cells. There are two sets of sibling pairs, suggesting CANVAS is a late-onset recessive disorder. The characteristic clinical sign-the visual vestibulo-ocular reflex deficit-can be demonstrated and measured clinically using video-oculography.

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“…Video‐oculography (VOG) allows easy, objective clinical assessment of the VOR 10–12 in the horizontal and vertical planes (see Figs. 1 and 3).…”

Section: Vvor With Video‐oculographymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS): a review of the clinical features and video‐oculographic diagnosis

Szmulewicz

Waterston

MacDougall

et al. 2011

Annals of the New York Academy of Sciences

140

112

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“…Manzari et al 93 reported that reduced oVEMPs and stable cVEMPs were observed in Lermoyez's syndrome, opposite to augmented oVEMPs and reduced cVEMPs during Meniere attacks, providing physiological evidence to support that Lermoyez's syndrome is a variant of Meniere's disease.…”

Section: Asymptomatic Hydrops In Unaffected Earsmentioning

confidence: 99%

Potential application of ocular and cervical vestibular‐evoked myogenic potentials in meniere's disease: A review

Young

2012

The Laryngoscope

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By stimulating the ear with air-conducted sound or bone-conducted vibration stimuli, vestibular-evoked myogenic potential (VEMP) can be recorded on the contracted neck muscles, termed cervical VEMP (cVEMP), and on the extraocular muscles, termed ocular VEMP (oVEMP). These two electrophysiological tests expand the test battery for clinicians to explore the dynamic otolithic function, adding a potential usefulness to the sacculocollic reflex and vestibulo-ocular reflex, respectively. The inner ear test battery, including audiometry, and cVEMP, oVEMP and caloric tests, is designed for complete evaluation of the inner ear function, namely, the cochlea, saccule, utricle, and semicircular canals, respectively. Using this test battery to study the localization and prevalence of hydrops formation reveals that the declining function in the cochlea, saccule, utricle, and semicircular canals mimics the declining sequence of hydrops formation in temporal bone studies. This study reviewed the physiological results in Meniere's patients via the inner ear test battery, especially the potential application of the oVEMP and cVEMP tests, to correlate with the histopathological findings of Meniere's disease.

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“…The simplicity of HIMPs and its relatively innocuous character for patients means that it can be used even during vertigo attacks. So it has been used to show in patients with Meni ere's disease how semicircular canal function fluctuates during and around the time of the attack of vertigo [34,35]. It has also been used to help discriminate between the vertigo due to Meni ere's disease as opposed to vertigo due to peripheral vestibular neuritis [36], as well as documenting the full recovery after peripheral vestibular neuritis [37].…”

Section: Advantagesmentioning

confidence: 99%

Clinical application of the head impulse test of semicircular canal function

Curthoys

Manzari²

2017

Hearing Balance and Communication

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Objective: To review the theory, the validity and the clinical application and the new developments of the video head impulse test (vHIT) of semicircular canal function. vHIT has now superseded the caloric test as the first-line clinical test for vestibular patients. Outcomes: This review examines the origin and rationale for vHIT: how it is carried out; pitfalls in testing; the validation of the test; the interpretation of overt and covert compensatory saccades in patients with vestibular loss; how the area VOR gain is calculated. Results: The advantages of the test are considered: it is so innocuous that it can be given to patients even during acute vertigo attacks, and given repeatedly at short intervals; it is very successful for testing young children; it tests all six semicircular canals, and, unlike the caloric test, provides measures of the absolute level of canal function and so is valuable for monitoring the effect of ototoxic antibiotics as well as identifying bilateral vestibular loss. Patients with Meni ere's disease have normal canal function, although their caloric results generally indicate otherwise, with hydrops being the possible cause for that divergence. vHIT has shown the new vestibular syndrome of bilateral loss of vertical canal function and it is now being used for identifying the likely cause of vertigo of patients arriving at a hospital Emergency Roomnormal semicircular canal function in such patients indicating increased probability of a stroke. The theory and application of the new, but already widely used, variant called the suppression head impulse test (SHIMPs) is explained. SHIMPs is even simpler and more intuitive than the standard vHIT test and probably even better for testing children. Conclusion: This review provides the theoretical foundations for the practical application of the clinical vHIT test which has revolutionized the clinical testing of semicircular canal function. Abbreviations: VOR: vestibulo-ocular reflex; HIT: head impulse test; vHIT: video head impulse testthe technology; HIMP: the head impulse testthe procedure; SHIMP: the suppression head impulse testthe procedure;

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Vestibular function in Lermoyez syndrome at attack

Cited by 20 publications

References 17 publications

Cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS): a review of the clinical features and video‐oculographic diagnosis

Cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS): a review of the clinical features and video‐oculographic diagnosis

Potential application of ocular and cervical vestibular‐evoked myogenic potentials in meniere's disease: A review

Clinical application of the head impulse test of semicircular canal function

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