Vestibular Functioning in Children with Neurodevelopmental Disorders Using the Functional Head Impulse Test

Caldani, Simona; Baghdadi, Moetez; Moscoso, Ana; Acquaviva, Éric; Gérard, Christophe; Marcelli, Vincenzo; Peyre, Hugo; Atzori, Paola; Delorme, Richard; Bucci, Maria Pia

doi:10.3390/brainsci10110887

Cited by 19 publications

(11 citation statements)

References 51 publications

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“…Specifically, after rotational stimulation subjects with ASD had a slower onset of the primary nystagmus response and fewer beats during the secondary response (Ornitz et al, 1985). Subjects with ASD have irregular patterns of horizontal gaze, abnormal rotationinduced vestibulo-ocular reflexes (VOR), and VOR-based tasks that were attributed to abnormal cerebellum and brainstem circuitry (Carson et al, 2017;Caldani et al, 2020). VOR has been proposed to serve some diagnostic value in ASD (Thabet, 2014).…”

Section: Vestibular and Cerebellar Issues In Asdmentioning

confidence: 99%

Central Auditory and Vestibular Dysfunction Are Key Features of Autism Spectrum Disorder

Mansour

Burchell

Kulesza

2021

Front. Integr. Neurosci.

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Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by repetitive behaviors, poor social skills, and difficulties with communication. Beyond these core signs and symptoms, the majority of subjects with ASD have some degree of auditory and vestibular dysfunction. Dysfunction in these sensory modalities is significant as normal cognitive development depends on an accurate representation of our environment. The hearing difficulties in ASD range from deafness to hypersensitivity and subjects with ASD have abnormal sound-evoked brainstem reflexes and brainstem auditory evoked potentials. Vestibular dysfunction in ASD includes postural instability, gait dysfunction, and impaired gaze. Untreated vestibular dysfunction in children can lead to delayed milestones such as sitting and walking and poor motor coordination later in life. Histopathological studies have revealed that subjects with ASD have significantly fewer neurons in the auditory hindbrain and surviving neurons are smaller and dysmorphic. These findings are consistent with auditory dysfunction. Further, the cerebellum was one of the first brain structures implicated in ASD and studies have revealed loss of Purkinje cells and the presence of ectopic neurons. Together, these studies suggest that normal auditory and vestibular function play major roles in the development of language and social abilities, and dysfunction in these systems may contribute to the core symptoms of ASD. Further, auditory and vestibular dysfunction in children may be overlooked or attributed to other neurodevelopmental disorders. Herein we review the literature on auditory and vestibular dysfunction in ASD. Based on these results we developed a brainstem model of central auditory and vestibular dysfunction in ASD and propose that simple, non-invasive but quantitative testing of hearing and vestibular function be added to newborn screening protocols.

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Section: Vestibular and Cerebellar Issues In Asdmentioning

confidence: 99%

Central Auditory and Vestibular Dysfunction Are Key Features of Autism Spectrum Disorder

Mansour

Burchell

Kulesza

2021

Front. Integr. Neurosci.

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“…Seven of the 11 studies targeting children were related to neurodevelopmental disorders (NDD), 21 22 23 24 25 26 27 two were motor development and ability studies, 28 29 and two were environmental exposure studies. 30 31 Most of the study subjects were patients with the targeted disease.…”

Section: Resultsmentioning

confidence: 99%

“…These studies used wearable and other types of devices. Caldani, et al, 22 Chu, et al, 23 Ness, et al, 27 and Khullar, et al 24 all used wearable devices. In the studies in which the measurement devices were directly attached to the body, vestibulo-ocular reflex, attention, biomarkers such as meditation, activity, eye tracking parameters, EEG activity, and ECG were measured.…”

Section: Resultsmentioning

confidence: 99%

“…The reviewed articles had various purposes such as health changes after disease, health effects due to environmental exposure, disease/disability/depression diagnosis, and health promotion. ECG was measured for all targets, but it was measured only when the purpose was “diagnosis.” 17 18 19 20 22 23 24 27 34 37 43 44 …”

Section: Discussionmentioning

confidence: 99%

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Digital Biomarkers in Living Labs for Vulnerable and Susceptible Individuals: An Integrative Literature Review

Park

Hong

et al. 2022

Yonsei Med J

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Purpose The study aimed to identify which digital biomarkers are collected and which specific devices are used according to vulnerable and susceptible individual characteristics in a living-lab setting. Materials and Methods A literature search, screening, and appraisal process was implemented using the Web of Science, Pubmed, and Embase databases. The search query included a combination of terms related to “digital biomarkers,” “devices that collect digital biomarkers,” and “vulnerable and susceptible groups.” After the screening and appraisal process, a total of 37 relevant articles were obtained. Results In elderly people, the main digital biomarkers measured were values related to physical activity. Most of the studies used sensors. The articles targeting children aimed to predict diseases, and most of them used devices that are simple and can induce some interest, such as wearable device-based smart toys. In those who were disabled, digital biomarkers that measured location-based movement for the purpose of diagnosing disabilities were widely used, and most were measured by easy-to-use devices that did not require detailed explanations. In the disadvantaged, digital biomarkers related to health promotion were measured, and various wearable devices, such as smart bands and headbands were used depending on the purpose and target. Conclusion As the digital biomarkers and devices that collect them vary depending on the characteristics of study subjects, researchers should pay attention not only to the purpose of the study but also the characteristics of study subjects when collecting and analyzing digital biomarkers from living labs.

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“…Importantly, we have to note that vestibular disabilities have been found to be related to various forms of cognitive impairments, such as visuospatial ability, attention, executive function, and memory [ 26 , 27 ]. Recently, our group [ 28 ] observed vestibular abnormalities in dyslexic children reported by deficits in the functional head vestibulo-ocular reflex. This reflex is specifically involved in the stabilization of the image on the retina during rapid movements of the head, and it plays an important role in the reading process [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Short Vestibular and Cognitive Training Improves Oral Reading Fluency in Children with Dyslexia

Caldani

Moiroud

Miquel³

et al. 2021

Brain Sciences

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(1) Background: This study explored the effect of short vestibular and cognitive training on the reading speed in dyslexic children. (2) Methods: The reading speed was evaluated by using a reading test (Évaluation de la Lecture en FluencE, ELFE) in a crossover design before (baseline) and after vestibular training (post VT) and no vestibular training (post no VT). Nineteen dyslexic children (9.48 ± 0.15 years) participated in the study. The vestibular and cognitive training (software developed by BeonSolution S.r.l.) consisted in four exercises presented on a Wacom tablet 10″ done for 16 min per session two times per week for four weeks; each exercise was composed of eight levels with increased difficulty. (3) Results: Following vestibular and cognitive training, dyslexic children increased their reading speed; interestingly, such an increase persisted at least one month after training. (4) Conclusions: Vestibular and cognitive training could improve the vestibular network, which is well known for being involved in several cognition functions leading to reading improvement in dyslexic children. Adaptive mechanisms could be responsible for maintaining such improvement for at least one month.

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Vestibular Functioning in Children with Neurodevelopmental Disorders Using the Functional Head Impulse Test

Cited by 19 publications

References 51 publications

Central Auditory and Vestibular Dysfunction Are Key Features of Autism Spectrum Disorder

Central Auditory and Vestibular Dysfunction Are Key Features of Autism Spectrum Disorder

Digital Biomarkers in Living Labs for Vulnerable and Susceptible Individuals: An Integrative Literature Review

Short Vestibular and Cognitive Training Improves Oral Reading Fluency in Children with Dyslexia

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