Veterinary Drugs: Progress in Multiresidue Technique

Regal, Patricia; Lamas, Alexandre; Franco, Carlos; Cepeda, Alberto

doi:10.1016/b978-0-08-100596-5.21809-x

Cited by 5 publications

(2 citation statements)

References 43 publications

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“…Although the use of multiresidue methods to quantify veterinary drugs in small sample amounts (<1 g or mL) is becoming more popular [41], the number of studies is still limited, and they often focus on a particular group of compounds. For example, Barco et al [42] validated a LC-MS method for analysis of 14 antibiotics (amikacin, amoxicillin, ceftazidime, ciprofloxacin, colistin, daptomycin, gentamicin, linezolid, meropenem, piperacillin, teicoplanin, tigecycline, tobramycin and vancomycin) and a β-lactamase inhibitor (tazobactam) using 100 µL of plasma from pediatric patients, obtaining good recoveries (>85%) and higher LOQ (100-2000 ng mL −1 ) than in our method.…”

Section: Methods Validationmentioning

confidence: 99%

“…Although other mass spectrometry detectors coupled to HPLC have been commonly used to detect pharmaceuticals [41], MS-TOF detectors are becoming more popular, as they are more accurate than any other instrument due to the excellent ion separation and detection in the flight tube that provide a much better identification of target analytes in complex matrices such as food and animal tissues [44], including screening and confirmatory multiresidue analysis of veterinary drugs in food [41].…”

Section: Methods Validationmentioning

confidence: 99%

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Validation of Multi-Residue Method for Quantification of Antibiotics and NSAIDs in Avian Scavengers by Using Small Amounts of Plasma in HPLC-MS-TOF

Gómez‐Ramírez

Blanco

García-Fernández

2020

IJERPH

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Pharmaceuticals are still considered emerging pollutants affecting both aquatic and terrestrial ecosystems. Scavenging bird species may be exposed to veterinary drugs when they feed on livestock carcasses provided at supplementary feeding stations, as these are often stocked with ailing and/or recently medicated animals. Because those animals may be a source of several different pharmaceutical compounds, analytical methods to evaluate residue levels and exposure potential should enable detection and quantification of as many different compounds as possible, preferably from small sample volumes. Four different extraction methods were tested to conduct HPLC-MS-TOF analysis of some of the most common veterinary drugs used in livestock in Spain. The method deemed most viable was a simple extraction, using methanol and 100 µL of plasma, that allowed quantification of seven antibiotics (tetracycline, oxytetracycline, ciprofloxacin, enrofloxacin, nalidixic acid, trimethoprim, sulfadiazine) and five nonsteroidal anti-inflammatory drugs (NSAIDs) (meloxicam, flunixin, carprofen, tolfenamic acid, phenylbutazone). The method was then applied to analysis of 29 Eurasian griffon vulture (Gyps fulvus) nestling samples, wherein enrofloxacin and tolfenamic acid were most commonly detected (69% and 20%, respectively). To our knowledge, this is the first study including NSAIDs in the exposure assessment of different classes of veterinary pharmaceuticals in live avian scavengers.

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Section: Methods Validationmentioning

confidence: 99%

Section: Methods Validationmentioning

confidence: 99%

Validation of Multi-Residue Method for Quantification of Antibiotics and NSAIDs in Avian Scavengers by Using Small Amounts of Plasma in HPLC-MS-TOF

Gómez‐Ramírez

Blanco

García-Fernández

2020

IJERPH

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Screening and Simultaneous Determination of 80 Veterinary Drug Residues in Food by HPLC-MS/MS

Amelin,

Batov,

Lavrukhina

et al. 2024

Inorg Mater

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Screening and simultaneous determination of 80 veterinary drugs residues in food by HPLC-MS/MS

Amelin,

Batov,

Lavrukhina

et al. 2023

Zavod. lab., Diagn. mater.

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A fast method of samples screening and determination of 80 veterinary drugs residues in food safety assessment is proposed. The solid-phase extraction for the extract purification in the sample preparation is excluded, at the same time the matrix effect is mitigated by the isotope-labeled standards using. The isotope dilution method allowed to exclude matrix calibration curves construction and calculate the concentration using correction coefficients found from analytes standard aqueous solutions and a limited number of isotope-labeled standards. The drugs residues limits of detection (cmin = 0,1 – 10 ng/g) allowed their determination at the maximum permissible levels for food.

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Veterinary Drugs: Progress in Multiresidue Technique

Cited by 5 publications

References 43 publications

Validation of Multi-Residue Method for Quantification of Antibiotics and NSAIDs in Avian Scavengers by Using Small Amounts of Plasma in HPLC-MS-TOF

Validation of Multi-Residue Method for Quantification of Antibiotics and NSAIDs in Avian Scavengers by Using Small Amounts of Plasma in HPLC-MS-TOF

Screening and Simultaneous Determination of 80 Veterinary Drug Residues in Food by HPLC-MS/MS

Screening and simultaneous determination of 80 veterinary drugs residues in food by HPLC-MS/MS

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