Vibrational characterization and prooxidant activity of newly synthesized dysprosium(III) complex

Kostova, Irena; Valcheva-Traykova, Maria; Balkansky, Stefan

doi:10.1007/s13738-015-0805-7

Cited by 4 publications

(2 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Raman spectra are particularly useful in studying the metal–oxygen stretching vibrations, since these vibrations give rise to medium intensity bands in Raman, but are weak in the infrared spectra. The observed bands and their assignments are in accordance with the literature data for similar coordination compounds [ 44 , 45 , 46 ].…”

Section: Methodssupporting

confidence: 90%

See 1 more Smart Citation

In Vitro Interaction of 5-Aminoorotic Acid and Its Gallium(III) Complex with Superoxide Radical, Generated by Two Model Systems

Todorov

Traykova

Saso³

et al. 2020

IJMS

Self Cite

View full text Add to dashboard Cite

Increased levels of the superoxide radical are associated with oxidative damage to healthy tissues and with elimination of malignant cells in a living body. It is desirable that a chemotherapeutic combines pro-oxidant behavior around and inside tumors with antioxidant action near healthy cells. A complex consisting of a pro-oxidant cation and antioxidant ligands could be a potential anticancer agent. Ga(III) salts are known anticancer substances, and 5-aminoorotic acid (HAOA) is a ligand with antioxidant properties. The in vitro effects of HAOA and its complex with Ga(III) (gallium(III) 5-aminoorotate (GaAOA)) on the in vitro accumulation of superoxide and other free radicals were estimated. Model systems such as potassium superoxide (KO2), xanthine/xanthine oxidase (X/XO), and rat blood serum were utilized. Data suggested better antioxidant effect of GaAOA compared to HAOA. Evidently, all three ligands of GaAOA participated in the scavenging of superoxide. The effects in rat blood serum were more nuanced, considering the chemical and biochemical complexity of this model system. It was observed that the free-radical-scavenging action of both compounds investigated may be manifested via both hydrogen donation and electron transfer pathways. It was proposed that the radical-scavenging activities (RSAs) of HAOA and its complex with Ga(III) may be due to a complex process, depending on the concentration, and on the environment, nature, and size of the free radical. The electron transfer pathway was considered as more probable in comparison to hydrogen donation in the scavenging of superoxide by 5-aminoorotic acid and its gallium(III) complex.

show abstract

Section: Methodssupporting

confidence: 90%

“…The complex was synthesized by reaction of Ga(III) nitrate and the ligand, in amounts equal to the metal/ligand molar ratio of 1:3 using an earlier described procedure [ 42 , 43 , 44 ]. Reaction of Ga(III) and 5-aminoorotic acid afforded a complex that was found to be quite stable both in solid state and in solution.…”

Section: Methodsmentioning

confidence: 99%