Vibrational Spectroscopic Methods for Nanosponges

Rossi, Barbara; D’Amico, Francesco; Masciovecchio, C.

doi:10.1002/9783527341009.ch8

Cited by 3 publications

(2 citation statements)

References 42 publications

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“…The obtained NSs were characterized by Raman and FT-IR spectroscopy, as can be seen in Figure 7 , and the assignment and discussion of the signals were determined based on related published data [ 10 , 54 , 55 , 56 , 57 ]. Spectrums were compared to observe their changes when the NSs were obtained.…”

Section: Resultsmentioning

confidence: 99%

β-Cyclodextrin-Based Nanosponges Inclusion Compounds Associated with Gold Nanorods for Potential NIR-II Drug Delivery

et al. 2022

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This article describes the synthesis and characterization of two nanocarriers consisting of β-cyclodextrin-based nanosponges (NSs) inclusion compounds (ICs) and gold nanorods (AuNRs) for potential near-infrared II (NIR-II) drug-delivery systems. These nanosystems sought to improve the stability of two drugs, namely melphalan (MPH) and curcumin (CUR), and to trigger their photothermal release after a laser irradiation stimulus (1064 nm). The inclusion of MPH and CUR inside each NS was confirmed by field emission scanning electron microscopy (FE-SEM), Raman spectroscopy, Fourier transform infrared spectroscopy, (FT-IR) differential scanning calorimetry (DSC), transmission electron microscopy (TEM), and proton nuclear magnetic resonance (1H-NMR). Furthermore, the association of AuNRs with both ICs was confirmed by FE-SEM, energy-dispersive spectroscopy (EDS), TEM, dynamic light scattering (DLS), ζ-potential, and UV–Vis. Moreover, the irradiation assays demonstrated the feasibility of the controlled-photothermal drug release of both MPH and CUR in the second biological window (1000–1300 nm). Finally, MTS assays depicted that the inclusion of MPH and CUR inside the cavities of NSs reduces the effects on mitochondrial activity, as compared to that observed in the free drugs. Overall, these results suggest the use of NSs associated with AuNRs as a potential technology of controlled drug delivery in tumor therapy, since they are efficient and non-toxic materials.

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Section: Resultsmentioning

confidence: 99%

β-Cyclodextrin-Based Nanosponges Inclusion Compounds Associated with Gold Nanorods for Potential NIR-II Drug Delivery

et al. 2022

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“…The vibrational properties of molecules allow the use of spectroscopic methods for a fairly accurate description of their structure and its evolution. Thus, vibrational spectroscopy can be used to confirm cross-linking and CDNS formation [ 139 ]. The most noticeable change in Fourier-transform infrared spectroscopy (FT-IR) spectra confirming the successful synthesis of CDNSs is the appearance of signals assigned to characteristic chemical groups of cross-linkers.…”

Section: Revision Of Cdnss’ Physicochemical Properties and Their Mutu...mentioning

confidence: 99%

Exploring Cyclodextrin-Based Nanosponges as Drug Delivery Systems: Understanding the Physicochemical Factors Influencing Drug Loading and Release Kinetics

Pyrak,

Rogacka-Pyrak,

Gubica

et al. 2024

IJMS

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Cyclodextrin-based nanosponges (CDNSs) are complex macromolecular structures composed of individual cyclodextrins (CDs) and nanochannels created between cross-linked CD units and cross-linkers. Due to their unique structural and physicochemical properties, CDNSs can possess even more beneficial pharmaceutical features than single CDs. In this comprehensive review, various aspects related to CDNSs are summarized. Particular attention was paid to overviewing structural properties, methods of synthesis, and physicochemical analysis of CDNSs using various analytical methods, such as DLS, PXRD, TGA, DSC, FT-IR, NMR, and phase solubility studies. Also, due to the significant role of CDNSs in pharmaceutical research and industry, aspects such as drug loading, drug release studies, and kinetics profile evaluation of drug–CDNS complexes were carefully reviewed. The aim of this paper is to find the relationships between the physicochemical features and to identify crucial characteristics that are influential for using CDNSs as convenient drug delivery systems.

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