Video-Assisted Thoracoscopic Surgery Is a Promising Treatment for Solitary Fibrous Tumor of the Pleura

Takahama, Makoto; Kushibe, Keiji; Kawaguchi, Takeshi; Kimura, Michitaka; Taniguchi, Shigeki

doi:10.1378/chest.125.3.1144

Cited by 43 publications

(39 citation statements)

References 21 publications

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“…Large tumors can also be treated by videothoracoscopy, whereas a utility thoracotomy can be added for the removal of the tumors, similar to 1 case in our study (13,22).…”

Section: Discussionsupporting

confidence: 57%

An unusual pathology with an undefined etiology:solitary fibrous tumors of the pleura

et al. 2016

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IntroductionPrimary tumors of the pleura are classified as diffuse and solitary. The solitary form was thought to be a form of mesothelioma and received different names such as localized mesothelioma, subpleural fibroma, benign mesothelioma, and subserous fibroma (1,2). It is recognized that the solitary fibrous tumor of the pleura (SFTP), which is rare and grows slowly, originates from mesenchymal cells of the submesothelial tissue of the pleura (3,4). No reports have demonstrated a correlation between SFTP and exposure to asbestos or any other carcinogens (5,6). Over 80% of these tumors are benign (1,4,7). They mostly appear between the 4th and 7th decades of life, half of them are asymptomatic, and they manifest as rounded, homogeneous masses with smooth margins on routine radiograms (8,9). Preoperative diagnosis is difficult because of nonspecific radiographic findings, and complete resection is the best prognostic factor (10-13).The aim of the present study was to identify any common or remarkable etiological factor or any biochemical abnormality or clinical presentation of SFTP, as well as to examine the best appropriate surgical approach and the results of long-term follow-up, and to compare these parameters with those reported in the literature. Materials and methodsBetween January 2001 and October 2014 the clinical and long-term follow-up records of 14 patients who had had surgery for SFTP were reviewed retrospectively. Common etiological factors, diagnostic procedures, and the clinical courses and outcomes for these patients were evaluated. The diagnosis of SFTP was confirmed by histomorphologic and immunohistochemical staining with hematoxylin/ eosin, CD34, vimentin, and cytokeratin. Malignancy criteria were described by England et al. (14) as more than 4 mitoses per 10 high-power fields, the presence of necrosis, and nuclear crowding and overlapping, which was defined as high cellularity and nuclear atypia. When one or more of these criteria was found histologically, the fibrous tumor was categorized as malignant (2,4). The classification of staging was based on de Perrot et al. Background/aim:The aim of the present study was to evaluate the etiology and clinical and pathological behavior of solitary fibrous tumors of the pleura (SFTPs), as well as the most appropriate surgical approach and the results of long-term follow-up of this condition.Materials and methods: Clinical and long-term follow-up records of 14 patients who had surgery for SFTP between 2001 and 2014 were reviewed retrospectively. Etiological factors, diagnostic procedures, and clinical courses and outcomes for these patients were studied.Results: Of the 14 patients, 8 were male (57%) and 6 were female (43%) patients. The mean age was 54.14 ± 10.35 (41-75) years. There was no remarkable common etiological factor. Preoperative diagnosis was achieved only in 2 patients. Predominant symptoms were cough and chest pain. Complete resection was achieved in all patients. Video-assisted thoracic surgery (VATS) was performed in 8 patients. All ...

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“…Large tumors can also be treated by videothoracoscopy, whereas a utility thoracotomy can be added for the removal of the tumors, similar to 1 case in our study (13,22).…”

Section: Discussionsupporting

confidence: 57%

An unusual pathology with an undefined etiology:solitary fibrous tumors of the pleura

et al. 2016

View full text Add to dashboard Cite

show abstract

“…De igual forma, como parte de los síndromes paraneoplásicos, puede presentarse la osteoartropatía hipertrófica pulmonar, secundaria a hipoxia crónica y manifestada por síntomas similares a los de la artritis y signos como los dedos en palillo de tambor 1,3,15 . Cabe resaltar que esta lesión neoplásica no se ha relacionado con ningún factor de riesgo conocido, descartándose su asociación con la exposición a asbesto o tabaco 4,5,15 . En el exámen físico se documenta la presencia de sibilancias, matidez a la percusión torácica y disminución de los ruidos respiratorios.…”

Section: Discussionunclassified

“…El tratamiento del tumor fibroso solitario de la pleura es netamente quirúrgico 4 . Se considera que la resección del tumor, ya sea por videotoracoscopia o toracotomía es curativa, con resolución de los síntomas en el corto a mediano plazo, incluyendo la hipoglucemia 4,56 .…”

Section: Características Diagnósticas Características Presentes En Crunclassified

“…Esta enfermedad tiene su origen en fibroblastos derivados del mesénquima submesotelial y se caracteriza por la formación de tumores localizados, generalmente únicos que no producen derrame pleural 3 . En la literatura se han descrito aproximadamente 800 casos de ésta neoplasia, la cual representa cerca del 8% de todos los tumores benignos intratoráxicos y menos del 10% de los tumores pleurales 4 . Su incidencia se ha calculado en alrededor de 2,8 casos por 100.000 pacientes registrados al año, por lo cual se les considera una lesión neoplásica poco frecuente 3,4 .…”

Section: Introductionunclassified

“…En la literatura se han descrito aproximadamente 800 casos de ésta neoplasia, la cual representa cerca del 8% de todos los tumores benignos intratoráxicos y menos del 10% de los tumores pleurales 4 . Su incidencia se ha calculado en alrededor de 2,8 casos por 100.000 pacientes registrados al año, por lo cual se les considera una lesión neoplásica poco frecuente 3,4 . En Latinoamérica existen pocas series de casos de ésta patología 5,6 y en Colombia no se encontró que se hayan reportado casos en la búsqueda de la literatura realizada.…”

Section: Introductionunclassified

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