Video characterization of flume patterns of inhalation aerosols

Miszuk, S.; Gupta, B.M.; Chen, F.C.; Clawans, C.; Knapp, Julius Z.

doi:10.1002/jps.2600690628

Cited by 11 publications

(3 citation statements)

References 6 publications

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“…As the aerosol is ejected from the actuator orifice at a high velocity and has a brief duration (< 0.1 s) the changes which it undergoes after ejection are not visible to the eye. Miszuk et al (1980) studied individual video images of flume patterns using two orthogonal images of the flume in two perpendicular planes. A close similarity was found in flume patterns of two corticosteroid inhalers and the photographic evaluation showed good correlation with the efficiency of drug delivery determined by liquid chromatography.…”

Section: Discussionmentioning

confidence: 99%

“…Variations in the formulation, type of propellant, vapour pressure, and the design of metering valves and actuators all determine the type of output from an inhaler . Photographic methods have also been used to evaluate the performance of the aerosol valve and actuator using both timed and non-timed exposures (Miszuk et al 1980; Benjamin et a1 1983). However, serial changes occurring in the flume after actuation were not described.…”

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confidence: 99%

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High speed photographic analysis of aerosols produced by metered dose inhalers

Dhand

Malik

Balakrishnan

et al. 1988

Journal of Pharmacy and Pharmacology

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The design of pressurized metered dose inhalers (MDI) used to assess asthma is variable. We have examined the aerosol spray flumes generated by four commercially available MDI products using high speed video photography. For this purpose a moulded jacket was designed which could hold the inhaler in an immovable position during actuation. Fresh inhalers were fitted in the jacket after thorough shaking and three successive actuations 30 s apart were filmed with a high speed video camera (200 frames s-1). The aerosol, ejected at high velocity into calm room air, was seen to have a 'jet' phase followed by a 'cloud' phase as a result of particle dispersion. Filming was continued till the flume could no longer be visualized on the TV monitor. High speed photography was used to record flumes seen on the video monitor, to enable characterization of flume appearance, dimensions and mean velocity.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

High speed photographic analysis of aerosols produced by metered dose inhalers

Dhand

Malik

Balakrishnan

et al. 1988

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

show abstract

“…Photographic (14) and laser holographic' methods also have been used. Miszuk et al (15) recently described a technique that utilizes two orthogonal video images. These methods are best suited for solution aerosols in which the active ingredient is dissolved Laser Photographic Laboratories, Arlington Heights, Ill. in the solvent/propellant.…”

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confidence: 99%