Videocapsule endoscopy is useful for the diagnosis of intestinal lymphangiectasia

Chamouard, P.; Nehme-Schuster, H.; Simler, Jean-Marc; Finck, G.; Baumann, René; Pasquali, J L

doi:10.1016/j.dld.2006.01.027

Cited by 53 publications

(30 citation statements)

References 17 publications

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“…In cases of sustained protein-losing enteropathy, capsule endoscopy may assist diagnosis. Chamouard et al [22] described a case of PIL that was detected using Given M2A video capsule endoscopy. Fang et al [10] reported the case of a female patient who was diagnosed with PIL by M2A capsule endoscopy and was confirmed by pathological examination.…”

Section: Discussionmentioning

confidence: 99%

Primary intestinal lymphangiectasia diagnosed by capsule endoscopy and double balloon enteroscopy

Oh¹

2011

WJGE

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Author contributions: Oh TG designed the case report as a main author; Chung JW and Kim HM contributed to provide background knowledge; Han SJ provided many informations about the patient; Lee JS provided genetic information and accessment; Park JY participated in endoscopic evaluation and accessment; Song SY supervised and checked up the manuscript finally as a corresponding author; all authors reviewed and approved the final manuscript. AbstractPrimary intestinal lymphangiectasia (PIL) is a rare disorder characterized by dilated intestinal lymphatics and the development of protein-losing enteropathy. Patients with PIL develop hypoalbuminemia, hypocalcemia, lymphopenia and hypogammaglobulinemia, and present with bilateral lower limb edema, fatigue, abdominal pain and diarrhea. Endoscopy reveals diffusely elongated, circumferential and polypoid mucosae covered with whitish enlarged villi, all of which indicate intestinal lymphangiectasia. Diagnosis is confirmed by characteristic tissue pathology, which includes dilated intestinal lymphatics with diffusely swollen mucosa and enlarged villi. The prevalence of PIL has increased since the introduction of capsule endoscopy. The etiology and prevalence of PIL remain unknown. Some studies have reported that several genes and regulatory molecules for lymphangiogenesis are related to PIL. We report the case of a patient with PIL involving the entire small bowel that was confirmed by capsule endoscopy and double-balloon enteroscopy-guided tissue pathology who carried a deletion on chromosome 4q25. The relationship between this deletion on chromosome 4 and PIL remains to be investigated.

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Section: Discussionmentioning

confidence: 99%

Primary intestinal lymphangiectasia diagnosed by capsule endoscopy and double balloon enteroscopy

Oh¹

2011

WJGE

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“…2b). Although, in the patient, capsule endoscopy provides a complete examination of the small intestinal mucosa, and thus, can evaluate the extent of lymphangiectasia, it is limited by an inability to obtain biopsies [5]. Currently, the diagnosis of intestinal lymphangiectasia is made based on characteristic findings on balloon enteroscopy, with further confirmation by histopathological examination of the corresponding biopsy specimens [6,7].…”

Section: Case Reportmentioning

confidence: 99%

Novel Magnified Single-Balloon Enteroscopy Enables Observation of Jejunal White Spots Associated with Lymphangiectasia

Tominaga

Tsuchiya

Kawata

et al. 2018

Dig Dis

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A 59-year-old woman was diagnosed with primary intestinal lymphangiectasia (PIL), with characteristic findings on capsule enteroscopy and confirmation by histopathological examination of biopsy specimens. We viewed the abnormal jejunal mucosa using a newly developed magnifying single-balloon enteroscope (SIF-Y0007). Conventional observation showed leakage of chyle. However, using this new scope, we could see scattered white villi, representing dilated lymphatic vessels within the intestinal villi protruding from the dilated submucosal lymphoid vessels (D2–40 positive) within an edematous jejunal lesion. This report is the first to describe the white villi in a patient with PIL observed clearly using a newly developed magnifying enteroscope. Technological advancements and the accumulation of reported pathological data would further improve our understanding of the pathophysiological aspects of this disease entity, even in the jejunum.

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“…This approach has significant shortcomings as the lymphatics maybe dilated only post prandial and not visualized when the endoscopy and biopsy were performed [3]. In addition if the region of small bowel involvement is distal to the duodenum this approach would give a falsely normal result [4][5][6][7][8][9][10][11]. This aspect assumes more significance as it's the patients who have localized involvement, benefit most from a definitive surgery wherein the involved segment would be removed and the patient would lead a normal life, with normal no dietary restrictions thereafter [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

“…Given the rarity of PIL the evaluation and management strategies have not changed much over the past decade [2]. There have been reports on successful usage of computerized tomography (CT) scan and video capsule endoscopy (VCE) to diagnose and delineate the extent of intestinal involvement [4][5][6][7][8][9][10][11][12]. The significance of determining the extent of involvement lies in the good response to surgical excision of the involved intestinal segment if a localized disease is present, as medical management outcomes are modest and often frustrating [13][14][15].…”

Section: Background and Aimsmentioning

confidence: 99%

MRI in Primary Intestinal Lymphangiectasia: A Diagnostic Tool and to Delineate Localization of Involvement

Varma¹

2016

GHOA

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Videocapsule endoscopy is useful for the diagnosis of intestinal lymphangiectasia

Cited by 53 publications

References 17 publications

Primary intestinal lymphangiectasia diagnosed by capsule endoscopy and double balloon enteroscopy

Primary intestinal lymphangiectasia diagnosed by capsule endoscopy and double balloon enteroscopy

Novel Magnified Single-Balloon Enteroscopy Enables Observation of Jejunal White Spots Associated with Lymphangiectasia

MRI in Primary Intestinal Lymphangiectasia: A Diagnostic Tool and to Delineate Localization of Involvement

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