Vindogentianine, a hypoglycemic alkaloid from Catharanthus roseus (L.) G. Don (Apocynaceae)

Tiong, Soon Huat; Looi, Chung Yeng; Arya, Aditya; Wong, Won Fen; Hazni, Hazrina; Mustafa, Mohd Rais; Awang, Khalijah

doi:10.1016/j.fitote.2015.01.019

Cited by 70 publications

(32 citation statements)

References 36 publications

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“…Some of the plants recorded have already been the subject of pharmacological studies and their antidiabetic activity shown, such as: Vernonia colorata (Odetola et al, 2006;Sy et al, 2007), C. roseus (Pousset, 2004;Tiong et al, 2015), M. charantia (Modak et al, 2007;Wang et al, 2014), Parkia biglobosa (Odetola et al, 2006), (Ojewole, 2002). Plants identified in the survey are shown in Table 2.…”

Section: Discussionmentioning

confidence: 99%

Ethnopharmacological survey of plants used in the treatment of diabetes mellitus in south of Togo (Maritime Region)

Kpodar

Lawson-Evi

Bakoma

et al. 2015

Journal of Herbal Medicine

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Section: Discussionmentioning

confidence: 99%

Ethnopharmacological survey of plants used in the treatment of diabetes mellitus in south of Togo (Maritime Region)

Kpodar

Lawson-Evi

Bakoma

et al. 2015

Journal of Herbal Medicine

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“…K E Y W O R D S antioxidant properties, bioactive compounds, Catharanthus roseus, drying methods, solvents 1 | I N TR ODU C TI ON Catharanthus roseus (L.) G. Don is native to Madagascar and is known as the Madagascar periwinkle. A range of alkaloids including vinblastine, vincristine, vindoline, vindolidine, vindolicine, vindolinine, and vindogentianine have been isolated (Cragg & Newman, Tiong et al, 2013Tiong et al, , 2015, and among them, vinblastine and vincristine were the first plant-derived anticancer agents in clinical use. Then, vinorelbine and vindesine, semi-synthetic analogues of these agents, were utilized in combination with other cancer chemotherapeutic drugs for various cancer treatments, including leukemias, lymphomas, advanced testicular cancer, breast and lung cancers, and Kaposi's sarcoma (Cragg & Newman, 2005;Svoboda, 1983).…”

mentioning

confidence: 99%

Effect of extraction solvents and thermal drying methods on bioactive compounds and antioxidant properties of Catharanthus roseus (L.) G. Don (Patricia White cultivar)

Pham

Vuong

Bowyer

et al. 2017

Journal of Food Processing and Preservation

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Catharanthus roseus (L.) G. Don (C. roseus) is well known as an important medicinal plant, with compounds such as the vinca alkaloids isolated for their anticancer activity. As such, it is important to determine the effective solvent for bioactive compound extraction from this plant and the suitable drying methods for preparation of starting material. The aims of this study were to determine the effect of extraction solvents and drying methods on bioactive compounds and antioxidant properties of C. roseus. Water was found to be the optimal solvent for phenolic and flavonoid extraction; whereas, methanol was the best solvent for saponin and proanthocyanidin extraction. The data also revealed that vacuum drying at 50°C was suitable for drying the leaf and the flower which contained high levels of phenolics and flavonoids, while infrared drying at 35°C was recommended for drying the stem and the root which had high saponin content. Practical applications This study suggested that different parts of C. roseus had different suitable thermal drying methods. For the leaf and the flower, vacuum drying at 50°C was the optimal drying method, whereas infrared drying at 35°C was suitable for drying the stem and the root. These drying conditions can be easily applied for preparation of dried plant parts with high levels of bioactive compounds in the large scale. Importantly, the data indicated that the stem and the root of C. roseus which were considered as waste when the leaf was used for exploiting alkaloids, possessed great content of saponins. Therefore, these parts can be further used for isolation and purification of saponins.

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“…Gentianine inhibits IL-1β-induced inflammatory responses in rats' articular chondrocytes by inhibiting the activity of P38, extracellular regulated protein kinases (ERK), and c-Jun N-terminal kinase (JNK). In addition, gentianine can also inhibit the release of matrix metalloproteinases (MMPs) induced by IL-1β and promote the expression of type II collagen [68]. Oral administration of 50 mg/kg of gentianine for 12 weeks can reduce body weight and visceral fat mass in mice, which was associated with reduced levels of inflammatory cytokines (NF-κb1, TNF-α, and IL-6).…”

Section: Gentianinementioning

confidence: 99%

Research Progress on Anti‐Inflammatory Effects and Mechanisms of Alkaloids from Chinese Medical Herbs

Liu

Chen

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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As the spectrum of diseases keeps changing and life pace keeps going faster, the probability and frequency of diseases caused by human inflammatory reactions also keep increasing. How to develop effective anti-inflammatory drugs has become the hotspot of researches. It has been found that alkaloids from Chinese medical herbs have anti-inflammatory, analgesic, antitumor, anticonvulsant, diuretic, and antiarrhythmic effects, among which the anti-inflammatory effect is very prominent and commonly used in the treatment of rheumatoid arthritis, ankylosing spondylitis, and other rheumatic immune diseases, but its mechanism of action has not been well explained. Based on this, this paper will classify alkaloids according to structural types and review the plant sources, applicable diseases, and anti-inflammatory mechanisms of 16 kinds of alkaloids commonly used in clinical treatment, such as berberine, tetrandrine, and stephanine, with the aim of providing a reference for drug researches and clinical applications. Isoquinoline AlkaloidsIsoquinoline alkaloids are widely distributed in 27 sections of plants, such as Menispermaceae, Berberidaceae, Papaveraceae, and Ranunculaceae [4]. Isoquinoline alkaloids, taking isoquinoline or tetrahydroisoquinoline as the basic parent nucleus, can be divided into 20 categories, including simple isoquinoline, benzylisoquinoline, phenethyl isoquinoline, naphthyl isoquinoline, aporphine, morphine,

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Vindogentianine, a hypoglycemic alkaloid from Catharanthus roseus (L.) G. Don (Apocynaceae)

Cited by 70 publications

References 36 publications

Ethnopharmacological survey of plants used in the treatment of diabetes mellitus in south of Togo (Maritime Region)

Ethnopharmacological survey of plants used in the treatment of diabetes mellitus in south of Togo (Maritime Region)

Effect of extraction solvents and thermal drying methods on bioactive compounds and antioxidant properties of Catharanthus roseus (L.) G. Don (Patricia White cultivar)

Research Progress on Anti‐Inflammatory Effects and Mechanisms of Alkaloids from Chinese Medical Herbs

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