Viral 3CLpro as a Target for Antiviral Intervention Using Milk-Derived Bioactive Peptides

Behzadipour, Yasaman; Gholampour, Maryam; Pirhadi, Somayeh; Seradj, Hassan; Khoshneviszadeh, Mahsima; Hemmati, Shiva

doi:10.1007/s10989-021-10284-y

Cited by 17 publications

(16 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effect of dairy on COVID-19 is greatly focused on fermented dairy products, mainly on those including probiotics, which is not consistent with our results, and are associated with an enhanced immunity and lower risk of infectious diseases, including COVID-19 (mainly based on the modulation of intestinal microbiome) ( 15 , 16 , 30 , 35 , 47 , 48 ). Similarly, there is evidence on the immune modulatory role of raw cow's milk on respiratory infections ( 49 ), and even a recent publication has also shown activity against SARS-CoV-2 of some milk-derived bioactive peptides ( 47 , 50 ). However, there are also publications that describe mechanisms that could explain the association found in this work.…”

Section: Discussionmentioning

confidence: 99%

Components of the Mediterranean Diet and Risk of COVID-19

et al. 2022

View full text Add to dashboard Cite

Adherence to the traditional Mediterranean diet has been customarily assessed with the Mediterranean diet score (MDS or Trichopolou Index), with values of 0 or 1 assigned to each of the nine elements, and with the use of the sex-specific median as the cutoff. The value of persons whose consumption of the six beneficial items (ratio of monounsaturated to saturated fatty acids, vegetables, legumes, fruits and nuts, cereal, and fish) is at or above the median and is assigned a value of 1. Otherwise they receive 0 points. For detrimental elements (meats and dairy products) persons whose consumption is below the median are assigned a value of 1. An additional ninth point is assigned to moderate ethanol intake. We assessed the effect of each of the nine components of the MDS (replacing the fats ratio with olive oil, the main source of monounsaturated fats in the Mediterranean diet) on the risk of COVID-19 infection, symptomatic and severe COVID-19. From March to December 2020, 9,699 participants of the “Seguimiento Universidad de Navarra” (SUN) cohort answered a COVID-19 questionnaire. After excluding doctors and nurses, 5,194 participants were included in the main statistical analyses. Among them, we observed 382 cases of COVID-19 based on symptoms and clinical diagnosis; 167 of them with test confirmation. For the two COVID-19 definitions used, we found a significant decrease in risk for a higher adherence to the Mediterranean diet (OR = 0.64, 95% CI: 0.42–0.98, p for trend = 0.040; and OR = 0.44, 95% CI: 0.22–0.88, p for trend = 0.020, for test-diagnosed cases). A protective effect was also found for symptomatic COVID-19 (OR = 0.64, 95% CI: 0.41–1.00, p for trend = 0.050). Among the different individual food groups, only the consumption of whole dairy products showed a harmful direct association. The Mediterranean diet as a whole seems more important than each of its components in preventing the infection and symptoms of COVID-19.

show abstract

Section: Discussionmentioning

confidence: 99%

Components of the Mediterranean Diet and Risk of COVID-19

et al. 2022

View full text Add to dashboard Cite

show abstract

“… 985 Behzadipour et al evaluated the SARS-CoV-2 Mpro inhibitory activity of 326 di- and tripeptides from the proteolysis of bovine milk proteins by docking. 986 Some works 974 , 987 , 988 aimed to repurpose peptides from seed proteins to targets Mpro, S protein, and PLpro. Some molecular modeling studies of the protein–protein binding were also contributed to treating SARS-CoV-2.…”

Section: Methods and Approachesmentioning

confidence: 99%

“…Zhao et al.’s docking studies identified GSRY among lactoferrin-derived peptides is potent to Mpro . Behzadipour et al evaluated the SARS-CoV-2 Mpro inhibitory activity of 326 di- and tripeptides from the proteolysis of bovine milk proteins by docking . Some works ,, aimed to repurpose peptides from seed proteins to targets Mpro, S protein, and PLpro.…”

Section: Methods and Approachesmentioning

confidence: 99%

Methodology-Centered Review of Molecular Modeling, Simulation, and Prediction of SARS-CoV-2

Gao¹,

Wang²,

Chen³

et al. 2022

Chem. Rev.

View full text Add to dashboard Cite

Despite tremendous efforts in the past two years, our understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune response, virulence, transmission, and evolution is still very limited. This limitation calls for further in-depth investigation. Computational studies have become an indispensable component in combating coronavirus disease 2019 (COVID-19) due to their low cost, their efficiency, and the fact that they are free from safety and ethical constraints. Additionally, the mechanism that governs the global evolution and transmission of SARS-CoV-2 cannot be revealed from individual experiments and was discovered by integrating genotyping of massive viral sequences, biophysical modeling of protein–protein interactions, deep mutational data, deep learning, and advanced mathematics. There exists a tsunami of literature on the molecular modeling, simulations, and predictions of SARS-CoV-2 and related developments of drugs, vaccines, antibodies, and diagnostics. To provide readers with a quick update about this literature, we present a comprehensive and systematic methodology-centered review. Aspects such as molecular biophysics, bioinformatics, cheminformatics, machine learning, and mathematics are discussed. This review will be beneficial to researchers who are looking for ways to contribute to SARS-CoV-2 studies and those who are interested in the status of the field.

show abstract

“…servations are yet to be confirmed in in vitro and in vivo studies. Behzadipour et al (2021) also documented the antiviral role of milk peptides obtained by the proteolysis of bovine milk CNs and WPs.…”

Section: S No Type Of Whey Proteins Name Of Virus In Vitro Mechanism ...mentioning

confidence: 97%

Preventative and therapeutic potential of animal milk components against COVID‐19: A comprehensive review

Singh¹,

Hernandez-Rauda

Peña‐Rodas

2023

Food Science & Nutrition

View full text Add to dashboard Cite

The global pandemic of COVID‐19 is considered one of the most catastrophic events on earth. During the pandemic, food ingredients may play crucial roles in preventing infectious diseases and sustaining people's general health and well‐being. Animal milk acts as a super food since it has the capacity to minimize the occurrence of viral infections due to inherent antiviral properties of its ingredients. SARS‐CoV‐2 virus infection can be prevented by immune‐enhancing and antiviral properties of caseins, α‐lactalbumin, β‐lactoglobulin, mucin, lactoferrin, lysozyme, lactoperoxidase, oligosaccharides, glycosaminoglycans, and glycerol monolaurate. Some of the milk proteins (i.e., lactoferrin) may work synergistically with antiviral medications (e.g., remdesivir), and enhance the effectiveness of treatment in this disease. Cytokine storm during COVID‐19 can be managed by casein hydrolyzates, lactoferrin, lysozyme, and lactoperoxidase. Thrombus formation can be prevented by casoplatelins as these can inhibit human platelet aggregation. Milk vitamins (i.e., A, D, E, and B complexes) and minerals (i.e., Ca, P, Mg, Zn, and Se) can have significantly positive effects on boosting the immunity and health status of individuals. In addition, certain vitamins and minerals can also act as antioxidants, anti‐inflammatory, and antivirals. Thus, the overall effect of milk might be a result of synergistic antiviral effects and host immunomodulator activities from multiple components. Due to multiple overlapping functions of milk ingredients, they can play vital and synergistic roles in prevention as well as supportive agents during principle therapy of COVID‐19.

show abstract

Viral 3CLpro as a Target for Antiviral Intervention Using Milk-Derived Bioactive Peptides

Cited by 17 publications

References 50 publications

Components of the Mediterranean Diet and Risk of COVID-19

Components of the Mediterranean Diet and Risk of COVID-19

Methodology-Centered Review of Molecular Modeling, Simulation, and Prediction of SARS-CoV-2

Preventative and therapeutic potential of animal milk components against COVID‐19: A comprehensive review

Contact Info

Product

Resources

About