2022
DOI: 10.1101/2022.11.14.516213
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Viral Airway Injury Promotes Cell Engraftment in anIn VitroModel of Cystic Fibrosis Cell Therapy

Abstract: Cell therapy is a potential treatment for cystic fibrosis (CF). However, cell engraftment into the airway epithelium is challenging. Here, we model cell engraftment in vitro using the air-liquid interface (ALI) culture system by injuring well-differentiated CF ALI cultures and delivering non-CF cells at the time of peak injury. Engraftment efficiency was quantified by measuring chimerism by droplet digital PCR and functional ion transport in Ussing chambers. Using this model, we found that human bronchial epit… Show more

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