Viral anterior uveitis

Jap, Aliza; Chee, Soon-Phaik

doi:10.1097/icu.0b013e32834be021

Cited by 89 publications

(86 citation statements)

References 47 publications

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“…Regarding the treatment of AU caused by HHVs, a recent review [45] states that aciclovir remains the mainstay of therapy for patients with HSV/VZV-AU and that CMV-AU is to be treated with ganciclovir ointment first, although prolonged therapy is required in many cases. For the treatment of CMV corneal endotheliitis, long-term topical ganciclovir (0.5%) and corticosteroids have been reported to preserve corneal endothelial cell function [46].…”

Section: Hsv1 Hsv2 Vzv and CMVmentioning

confidence: 99%

A new era of uveitis: impact of polymerase chain reaction in intraocular inflammatory diseases

et al. 2016

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Uveitis is a sight-threatening intraocular inflammatory disorder which may occur from both infectious and non-infectious or autoimmune causes. The frequency of infectious uveitis and autoimmune uveitis varies depending on countries and regions. According to a nationwide survey conducted by the Japanese Ocular Inflammation Society, infectious and non-infectious uveitis accounted for 16.4 and 50.1% of new patients, respectively while the remaining 33.5% of new uveitis cases were not classified or were idiopathic uveitis. Infectious uveitis is particularly important because it causes tissue damage to the eye and may result in blindness unless treated. However, it can be treated if the pathogenic microorganisms are identified promptly and accurately. Remarkable advancements in molecular and immunological technologies have been made in the last decade, and the diagnosis of infectious uveitis has been greatly improved by the application of molecular and immunological investigations, particularly polymerase chain reaction (PCR). PCR performed on a small amount of ocular samples provides a prompt, sensitive, and specific molecular diagnosis of pathogenic microorganisms in the eye. This technology has opened a new era in the diagnosis and treatment of uveitis, enabling physicians to establish new clinical entities of uveitis caused by infectious microorganisms, identify pathogens in the eyes of many patients with uveitis, and determine prompt diagnosis and appropriate therapy. Here we review the PCR process, new PCR tests specialized for ocular diseases, microorganisms detected by the PCR tests, diseases in the eye caused by these microorganisms, and the clinical characteristics, diagnosis, and therapy of uveitis.

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Section: Hsv1 Hsv2 Vzv and CMVmentioning

confidence: 99%

A new era of uveitis: impact of polymerase chain reaction in intraocular inflammatory diseases

et al. 2016

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“…2 It is usually associated with increased intraocular pressure. 2 Chee and Jap 3 also reported the presence of an immune ring in the cornea of patients with CMV anterior uveitis.…”

mentioning

confidence: 99%

“…2 It is usually associated with increased intraocular pressure. 2 Chee and Jap 3 also reported the presence of an immune ring in the cornea of patients with CMV anterior uveitis. Nodular endothelial lesions are white, mediumsized, nodular lesions surrounded by a translucent halo, which are significantly associated with CMV infection in cases of chronic anterior uveitis.…”

mentioning

confidence: 99%

“…Nodular endothelial lesions are white, mediumsized, nodular lesions surrounded by a translucent halo, which are significantly associated with CMV infection in cases of chronic anterior uveitis. 2,3 Anterior uveitis with ocular hypertension resistant to topical steroid therapy and not clinically suggestive of the herpes group of virus makes the clinician suspect CMV infection. 2 CMV anterior uveitis responds to ganciclovir, but the relapse rate is high and prolonged therapy may be required.…”

mentioning

confidence: 99%

“…2,3 Anterior uveitis with ocular hypertension resistant to topical steroid therapy and not clinically suggestive of the herpes group of virus makes the clinician suspect CMV infection. 2 CMV anterior uveitis responds to ganciclovir, but the relapse rate is high and prolonged therapy may be required. As reported by Jap and Chee, 2 ganciclovir gel induced a response in two-thirds, but uveitis recurred in 57% of acute and 25% of chronic inflammation.…”

mentioning

confidence: 99%

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