Viral Capsids Mimicking Based on pH-Sensitive Biodegradable Polymeric Micelles for Efficient Anticancer Drug Delivery

Jiang, Lutao; Liang, Yan; Huo, Qingqing; Pu, Yuji; Lü, Wei; Han, Shangcong; Cao, Jie; He, Bin; Sun, Yong

doi:10.1166/jbn.2018.2587

Cited by 15 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When the critical micelle concentration was reached, amphiphilic polymers self-assembled as nanosized particles, namely, micelles [127,128]. Particles with a smaller size and neutral charge may arrive more easily at the draining lymph nodes and enhance systemic spread [90,[129][130][131][132].…”

Section: Novel Biomaterials For Cancer Immunotherapy Lipid-based Biommentioning

confidence: 99%

Advanced biomaterials for cancer immunotherapy

et al. 2020

View full text Add to dashboard Cite

Immunotherapy, as a powerful strategy for cancer treatment, has achieved tremendous efficacy in clinical trials. Despite these advancements, there is much to do in terms of enhancing therapeutic benefits and decreasing the side effects of cancer immunotherapy. Advanced nanobiomaterials, including liposomes, polymers, and silica, play a vital role in the codelivery of drugs and immunomodulators. These nanobiomaterial-based delivery systems could effectively promote antitumor immune responses and simultaneously reduce toxic adverse effects. Furthermore, nanobiomaterials may also combine with each other or with traditional drugs via different mechanisms, thus giving rise to more accurate and efficient tumor treatment. Here, an overview of the latest advancement in these nanobiomaterials used for cancer immunotherapy is given, describing outstanding systems, including lipid-based nanoparticles, polymer-based scaffolds or micelles, inorganic nanosystems, and others.

show abstract

Section: Novel Biomaterials For Cancer Immunotherapy Lipid-based Biommentioning

confidence: 99%

Advanced biomaterials for cancer immunotherapy

et al. 2020

View full text Add to dashboard Cite

show abstract

“…For initial study of cellular internalization, NPs-EPI was incubated with tumor spheroids at an EPI concentration of 8 µg/mL for 4 h. The tumor spheroids were grown as our previous reported procedure. 27 Briefly, HepG2 cells were seeded in 96-well plates at a density of 8×10 3 per well precoated with 50 µL of 1% low melting point agarose. 28 Cells were cultured to obtain multicellular spheroids (400–500 μm in diameter) for subsequent studies.…”

Section: Methodsmentioning

confidence: 99%

<p>Mechanism Investigation of Hyaluronidase-Combined Multistage Nanoparticles for Solid Tumor Penetration and Antitumor Effect</p>

Chen

Han

Song

et al. 2020

IJN

Self Cite

View full text Add to dashboard Cite

Background: Hyaluronic acid (HA) is a major component of extracellular matrix (ECM) and its over expression in tumor tissues contributes to the increase of interstitial fluid pressure (IFP) and hinders the penetration of nanoparticles into solid tumors. Materials and Methods: We here reported a tumoral microenvironment responsive multistage drug delivery system (NPs-EPI/HAase) which was formed layer by layer via electrostatic interaction with epirubicin (EPI)-loaded PEG-b-poly(2-(diisopropylamino)ethyl methacrylate)-b-poly(2-guanidinoethylmethacrylate) (mPEG-PDPA-PG, PEDG) micelles (NPs-EPI) and hyaluronidase (HAase). In this paper, we focused on the hyaluronidasecombined nanoparticles (NPs-EPI/HAase) for tumor penetration in tumor spheroid and solid tumor models in vitro and in vivo. Results: Our results showed that NPs-EPI/HAase effectively degrade the HA in ECM and facilitate deep penetration of NPs-EPI into solid tumor. Moreover, NPs-EPI mainly employed clathrin-mediated and macropinocytosis-mediated endocytic pathways for cellular uptake and were subsequently directed to the lysosomes for further drug release triggered by proton sponge effect. Compared with NPs-EPI, the HAase coating group showed an enhanced tumoral drug delivery efficacy and inhibition of tumor growth. Conclusion: Overall, our studies demonstrated that coating nanoparticles with HAase can provide a simple but efficient strategy for nano-drug carriers to enhance solid tumor penetration and chemotherapeutic efficacy.

show abstract

“…As an alternative approach to enzymes, linkers or tethers with pH-responsive functionalities can be introduced in the particle design, to shield ligands during blood circulation, and increase their targeting once an acidic environment is reached [ [195] , [196] , [197] , [198] ]. Furthermore, pH-responsiveness can be used to initiate cargo release in acidic intracellular compartments or tumor milieus [ [199] , [200] , [201] ]. It can also be adopted to mimic the viral trait of endosomal escape [ 202 , 203 ] which is mediated by membrane fusion or disruption, for enveloped and non-enveloped viruses [ 204 ], respectively.…”

Section: Stimuli Responsivenessmentioning

confidence: 99%

Biomedical nanoparticle design: What we can learn from viruses

Figueroa

Fleischmann

Goepferich

2021

Journal of Controlled Release

View full text Add to dashboard Cite

Viruses are nanomaterials with a number of properties that surpass those of many synthetic nanoparticles (NPs) for biomedical applications. They possess a rigorously ordered structure, come in a variety of shapes, and present unique surface elements, such as spikes. These attributes facilitate propitious biodistribution, the crossing of complex biological barriers and a minutely coordinated interaction with cells. Due to the orchestrated sequence of interactions of their stringently arranged particle corona with cellular surface receptors they effectively identify and infect their host cells with utmost specificity, while evading the immune system at the same time. Furthermore, their efficacy is enhanced by their response to stimuli and the ability to spread from cell to cell. Over the years, great efforts have been made to mimic distinct viral traits to improve biomedical nanomaterial performance. However, a closer look at the literature reveals that no comprehensive evaluation of the benefit of virus-mimetic material design on the targeting efficiency of nanomaterials exists. In this review we, therefore, elucidate the impact that viral properties had on fundamental advances in outfitting nanomaterials with the ability to interact specifically with their target cells. We give a comprehensive overview of the diverse design strategies and identify critical steps on the way to reducing them to practice. More so, we discuss the advantages and future perspectives of a virus-mimetic nanomaterial design and try to elucidate if viral mimicry holds the key for better NP targeting.

show abstract

Viral Capsids Mimicking Based on pH-Sensitive Biodegradable Polymeric Micelles for Efficient Anticancer Drug Delivery

Cited by 15 publications

References 0 publications

Advanced biomaterials for cancer immunotherapy

Advanced biomaterials for cancer immunotherapy

<p>Mechanism Investigation of Hyaluronidase-Combined Multistage Nanoparticles for Solid Tumor Penetration and Antitumor Effect</p>

Biomedical nanoparticle design: What we can learn from viruses

Contact Info

Product

Resources

About