Viral Diabetes

Replication of the Pseudorabies Virus in Cultured Pancreatic Islet Cells: Further Evidence of Their Paraneuronal Nature.

“…Ultrastructural investigations have revealed the presence of viruses or of viral particles in the B cells of the Langerhans islets in diabetes or diabetes-like conditions (LIKE and CHICK, 1970;ONODERA et al, 1978;OLDSTONE et al, 1984;SUENAGA and YOON, 1988). Several animal models have been proposed in which different viruses, the majority of them being neurotropic, have been claimed to cause structural alteration in the B cells of the Langerhans islets, combined with a dysregulation of the carbohydrate homeostasis (CRAIGHEAD et al, 1974;CRAIGHEAD, 1977;YOON et al, 1981;RAYFIELD et al, 1976RAYFIELD et al, , 1986KURATA et al, 1987;PAK et al, 1988;BOCHAROV et al, 1988).…”