Viral hepatitis as a risk factor for the development of hepatocellular carcinoma

Alqahtani, Saleh A.; Colombo, Massimo

doi:10.20517/2394-5079.2020.49

Cited by 16 publications

(15 citation statements)

References 150 publications

(193 reference statements)

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“…This study showed that donors with the O blood group, particularly those with O RhD +ve blood group, were more at risk of developing TTIs, whereas donors with the AB blood group, the AB RhD −ve blood group, in particular, were at the lowest risk of developing TTIs. According to a study by Farwa Sijjeel et al, donors with blood group O were found to be highly contaminated with TTIs [ 13 ]. On the other hand, donors with blood group A were shown to be at a higher risk of developing HBV and HIV, while those with group O showed no significant association with TTIs in research conducted in Peshawar, Pakistan [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and Association of Transfusion Transmitted Infections with ABO and Rh Blood Groups among Blood Donors in the Western Region of Saudi Arabia: A 7-Year Retrospective Analysis

et al. 2022

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This study was aimed at determining the prevalence estimate and association of transfusion-transmitted infections (TTIs) with ABO and Rh blood groups among blood donors at the King Faisal Specialist Hospital and Research Center (KFSH & RC) in the western region of Saudi Arabia. A retrospective study was conducted at the blood bank center of KFSH and RC from 1 January 2013 to 31 December 2019. Data on ABO and Rh blood group testing, serological testing, molecular investigations, serological assays, nucleic acid testing (NATs), and socio-demographic information were gathered. During the study period, there were 959,431 blood donors at the KFSH and RC. The overall 7-year cumulative prevalence estimate of blood transfusion-transmitted infections among blood donors was low at 7.93%, with an average prevalence estimate of 0.66%. Donors with the O blood group, the O RhD +ve blood group, in particular, were more at risk of developing TTIs, whereas donors with the AB blood group, the AB RhD −ve blood group, in particular, were at the lowest risk of developing TTIs. In total, 96.9% of the blood donors were males (n = 916,567). Almost half of the blood donors belong to the O blood group (49.4%). A total of 861,279 (91.0%) donors were found to be RhD positive. The percentages of TTIs were found to be higher in RhD +ve donors compared with RhD −ve donors. The prevalence estimate of the hemoglobin C (HbC) infection was the most common TTI among the blood donors being 3.97%, followed by malaria being 2.21%. The least prevalence estimate of TTI in the present study was for NAT HIV being 0.02%. Significant associations were observed between RhD +ve and RhD −ve among the malaria-infected donors (A: χ2 = 26.618, p = 0.001; AB: χ2 = 23.540, p = 0.001; B: χ2 = 5.419, p = 0.020; O: χ2 = 68.701, p = 0.001). The current 7-year retrospective study showed a low level of TTIs among blood donors. However, we urge that more research encompassing the entire country be conducted in order to obtain more representative results in terms of the prevalence estimate and association of transfusion-transmitted infections with ABO and Rh blood groups in communities.

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Section: Discussionmentioning

confidence: 99%

“…Individuals with a chronic hepatitis B infection have a higher risk of developing liver cirrhosis and cancer, as well as a variety of other disorders. This infection is extremely contagious [ 13 ]. Due to their similar viral transmission paths, HCV and HBV infections are well-known among HIV patients.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Association of Transfusion Transmitted Infections with ABO and Rh Blood Groups among Blood Donors in the Western Region of Saudi Arabia: A 7-Year Retrospective Analysis

et al. 2022

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“…Viral hepatitis is one of the major contributing factors to cirrhosis and liver cancer 30 . Fungal diversity and composition were studied, via culture‐independent and culture‐dependent methods, in faecal samples from patients with chronic HBV infection with and without cirrhosis, and healthy volunteers.…”

Section: Associations Of Fungi With the Development And Progression O...mentioning

confidence: 99%

Roles for the mycobiome in liver disease

Zeng

Schnabl

2022

Liver International

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Liver disease, a major cause of global mortality, has been associated with dysbiosis of the intestinal microbiota (bacteria, fungi, viruses, and other microbes). Studies have associated changes in gut bacteria with pathogenesis and severity of liver disease, but the contributions of the mycobiome (the fungal populations of the gut) to health and disease have not been well studied. We review recent findings of alterations in the composition of the mycobiota in patients with liver disease and discuss the mechanisms by which these might affect pathogenesis and disease progression. Strategies to manipulate the gut mycobiota might be developed to treat or prevent liver disease.

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“…Data analysis was based on group-consensus analysis method 20 . The reference result was the result with 80% similar level among participated laboratories in the same method 21 . In case of similar level below 80% or group method testing below 10 participated labs using, the reference result would be from EQA provider.…”

Section: Discussionmentioning

confidence: 99%

External quality assessment for dual detection of HBsAg and anti-HCV in serum

Thuan¹,

Uyen²,

Chuong³

et al. 2022

Pharm Sci Asia

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Hepatitis B surface Antigen (HBsAg) and hepatitis C antibody (anti-HCV) assays have been performed in most laboratories using a variety of analytical methods with different reagents for Hepatitis B virus (HBV) and Hepatitis C virus (HCV) screening [1][2] . The purpose of this study was to develop an EQA program for dual HBsAg and anti-HCV serological testing to ensure the accuracy and reliability of serological assays. A serum panel of 12 samples containing three negative, three positives for each virus and three positives for both of HBsAg and anti-HCV. These panels were distributed to 102 laboratories in the South of Vietnam. They were required to report their results and any problems encountered on EQA panel. The results show that performance of HBsAg and anti-HCV tests is not only different in terms of method used but also in the types of biological products. Rapid tests (RTs) to detect HBsAg and anti-HCV were most commonly used to screen for HBV and HCV in laboratories. The coincidence rates of RTs for HBsAg and anti-HCV serological assays were 88.24% and 89.86% respectively, while electrochemiluminescence (ECLs) and chemiluminescent immunoassays (CLIAs), Enzymelinked immunosorbent assay (ELISA) showed the best performance for both HBsAg and anti-HCV testing. The most challenging was failed to detect weak positive samples. In conclusion, the differences in test results within and between groups of HBsAg and anti-HCV assay methods indicated a need to improve test conditions at laboratories in Viet Nam.

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Viral hepatitis as a risk factor for the development of hepatocellular carcinoma

Abstract: How to cite this article: Alqahtani SA, Colombo M. Viral hepatitis as a risk factor for the development of hepatocellular carcinoma.

Cited by 16 publications

References 150 publications

Prevalence and Association of Transfusion Transmitted Infections with ABO and Rh Blood Groups among Blood Donors in the Western Region of Saudi Arabia: A 7-Year Retrospective Analysis

Prevalence and Association of Transfusion Transmitted Infections with ABO and Rh Blood Groups among Blood Donors in the Western Region of Saudi Arabia: A 7-Year Retrospective Analysis

Roles for the mycobiome in liver disease

External quality assessment for dual detection of HBsAg and anti-HCV in serum

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