Viral pathogens in urological diseases

Krakhotkin, D.V.; Иванов, С. Н.; Набока, Ю. Л.; Коган, М. И.; Гудима, И А; Ильяш, А. В.; Савкин, М. Э.; Красулин, В. В.; Сизякин, Д. В.

doi:10.21886/2219-8075-2018-9-4-14-21

Med. vestn. Ûga Ross.

2018

DOI: 10.21886/2219-8075-2018-9-4-14-21

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Viral pathogens in urological diseases

D.V. Krakhotkin

С. Н. Иванов

Ю. Л. Набока

et al.

Abstract: Tis review describes diﬀerent virus taxa that are more prevalent in some variants of urological pathology. Te search of articles was conducted in the information portals of Te Cochrane Database, MEDLINE / PubMed Database, eLIBRARY, ClinicalKey for the period 2008-2018. As a result, the most current and representative studies, containing an interpretation of the dynamics of opinions indicating the involvement of viruses in various urological diseases were selected. Te bacterial component is the most studied in … Show more

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Cited by 2 publications

References 41 publications

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Urine microbiota and bladder cancer

Lisitsyn,

Maistrenko,

Granov

et al. 2024

Urology reports (St. - Petersburg)

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Urine analysis data obtained using modern microbiological methods and 16S rRNA gene sequencing technology indicate that the urinary system has its own microbial ecosystem. Individual microbiota members can play a key role in the development of cancer. Certain bacterial taxa have been revealed in bladder urothelial carcinoma cells that can affect carcinogenesis, treatment response, and the development of relapses through various mechanisms. The studies are conducted to use not only vaccine strains, but also probiotic strains and oncolytic bacteria for the treatment and prevention of relapses.

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Urine microbiota and bladder cancer

Lisitsyn,

Maistrenko,

Granov

et al. 2024

Urology reports (St. - Petersburg)

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Bacterial-viral Urine Microbiota in Uncomplicated Recurrent Infection of the Lower Urinary Tract: Results of Pilot Study

et al. 2020

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Introduction. Difficulties in the management and treatment of patients with uncomplicated recurrent lower urinary tract infection (LUTI) are largely because bacterial, viral and other components remain unexplored in the etiological structure of the disease.Purpose of the study. To study the urine bacterial-viral associations in uncomplicated recurrent infections of the lower urinary tract (LUT).Materials and methods. The study included 14 patients with uncomplicated recurrent infections of the LUT, the average age was 33.0 ± 4.7 years. The object of the study was the average portion of morning urine collected prior to the appointment of empirical antibiotic therapy. Urine was divided into 3 aliquots: 1 for general urine analysis, 2 for bacteriological examination, 3 for polymerase chain reaction (PCR).Results. Aerobic-anaerobic associations were found in urine in all cases. Enterobacteriaceae family representatives were discovered in 92.8% of cases; they were represented by E. coli (78.6%), Klebsiella spp. (14.2%), Proteus spp. (7.1%). Moreover, in one patient at the same time (7.1%) E. coli + Klebsiella spp was isolated from urine.The gram-positive microflora pattern consisted of 7 genera and / or species and in various combinations was found in all patients. The taxonomic structure of the gram-positive flora was represented by E. faecalis (64.3%), S. lentus (21.4%), Corynebacterium spp., S. warneri, E. faecium (14.3% each), S. epidermidis + E. coli was recorded in 4 (28.6%) women, E. faecalis + E. faecium + E. coli + Klebsiella spp. - in 1 (7.1%), E. faecalis + E. faecium + E. coli also in 1 (7.1%) patients.Non-clostridial anaerobic bacteria (NAB) were isolated from urine in all cases with Eubacterium spp dominating. (57.1%). The taxonomic structure of NAB was represented by 5 genera: Eubacterium spp., Peptostreptococcus spp., Peptococcus spp., Bifidobacterium spp., Propionibacterium spp.Viruses were detected in urine in 6 (42.9%) patients. Epstein-Barr virus (EBV) was detected in 4 (28.6%) of them, moreover, in 1 case, in association with human papillomavirus (HPV53), in two other cases (7.1% each), cytomegalovirus (CMV) was verified and human herpes simplex virus type 6 (HHV6), respectively.Conclusions. In patients with uncomplicated recurrent LUTI, viruses with a prevalence of EBV were verified in urine in 42.9% of cases (28.6%). Apparently, the treatment of this patients` cohort should be directed not only to the bacterial, but also the viral components of the urinary microbiota.

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Viral pathogens in urological diseases

Cited by 2 publications

References 41 publications

Urine microbiota and bladder cancer

Urine microbiota and bladder cancer

Bacterial-viral Urine Microbiota in Uncomplicated Recurrent Infection of the Lower Urinary Tract: Results of Pilot Study

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