Virgin coconut oil supplementation attenuates acute chemotherapy hepatotoxicity induced by anticancer drug methotrexate via inhibition of oxidative stress in rats

Famurewa, Ademola C.; Ufebe, Odomero G.; Egedigwe, Chima A.; Nwankwo, Onyebuchi E.; G, Obaje

doi:10.1016/j.biopha.2016.12.123

Cited by 60 publications

(32 citation statements)

References 44 publications

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“…They are, therefore, promising candidates for obesity therapeutics . Previous studies using dietary coconut oil have shown its health benefits toward hepatotoxicity, together with altered lipid profiles in the body . Another unique feature of coconut oil is the low abundance of both n‐3 and n‐6 essential FAs.…”

Section: Introductionmentioning

confidence: 99%

Dietary coconut oil ameliorates skin contact hypersensitivity through mead acid production in mice

Tiwari

Nagatake

Hirata

et al. 2019

Allergy

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Coconut oil is used as a dietary oil worldwide, and its healthy effects are recognized by the fact that coconut oil is easy to digest, helps in weight management, increases healthy cholesterol, and provides instant energy. Although topical application of coconut oil is known to reduce skin infection and inflammation, whether dietary coconut oil has any role in decreasing skin inflammation is unknown. In this study, we showed the impact of dietary coconut oil in allergic skin inflammation by using a mouse model of contact hypersensitivity (CHS). Mice maintained on coconut oil showed amelioration of skin inflammation and increased levels of cis-5, 8, 11-eicosatrienoic acid (mead acid) in serum. Intraperitoneal injection of mead acid inhibited CHS and reduced the number of neutrophils infiltrating to the skin. Detailed mechanistic studies unveiled that mead acid inhibited the directional migration of neutrophils by inhibiting the filamentous actin polymerization and leukotriene B 4 production required for secondary recruitment of neutrophils. Our findings provide valuable insights into the preventive roles of coconut oil and mead acid against skin inflammation, thereby offering attractive therapeutic possibilities. K E Y W O R D S coconut oil, LTB 4 , mead acid, neutrophils, skin inflammation | 1523 TIWARI eT Al.

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Section: Introductionmentioning

confidence: 99%

Dietary coconut oil ameliorates skin contact hypersensitivity through mead acid production in mice

Tiwari

Nagatake

Hirata

et al. 2019

Allergy

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“…Hepatotoxicity is one of the chief side effects of MTX limiting its clinical use [10]. In spite of some vagueness regarding the mechanism of MTX-induced liver injury, there are many studies indicating the oxidative stress and triggering of inflammatory response as being the main causes [3,11]. This necessitates looking for agents with probable hepatoprotective properties to ameliorate the toxic effects of MTX.…”

Section: Discussionmentioning

confidence: 99%

“…MTX blocks the synthesis of nucleic acids, certain amino acids, and consequently proteins, and this leads to damage of organelles and plasma membranes of the hepatic parenchymal cells, interfering with their function and allowing leakage of enzymes [15]. ALP and bilirubin are sensitive markers for the investigation of biliary function [3]. Total bilirubin level is a marker for extensive liver damage or direct inhibition of biliary transporters [16].…”

Section: Discussionmentioning

confidence: 99%

“…It can cause diverse toxic effects on many body organs such as bone marrow, skin, mucosal membranes, and gastrointestinal tract [2], but its most disabling toxic effect is hepatotoxicity, represented as increased transaminases, hepatitis, fibrosis, and cirrhosis. Despite some vagueness regarding the mechanism of MTX-induced liver injury, it is believed that the oxidative stress and resultant inflammatory response are the main causes [3].…”

Section: Introductionmentioning

confidence: 99%

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The Protective Effects of Echinops Heterophyllus Aqueous Extract Against Methotrexate-Induced Hepatotoxicity in Rabbits

Abdulmohsin

Raghif

Manna

2019

Asian J Pharm Clin Res

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Objective: The aim of this study was to investigate antioxidant and hepatoprotective properties of Iraqi Echinops heterophyllus aqueous crude extract and its flavonoid fraction against methotrexate (MTX)-induced hepatotoxicity in rabbits.Methods: MTX-induced hepatotoxicity by administration of 20 mg/kg MTX intraperitoneally for 3 successive days was used as animal model, and animals were arrayed in four groups with eight animals in each group: Group 1 was the healthy control, Group 2 - the negative control receiving MTX only, Group 3 received MTX+crude extract of E. heterophyllus, and Group 4 administered MTX+flavonoid fraction of E. heterophyllus. The study duration was 10 days; at day 11, animals were sacrificed, and the blood samples were obtained for the measurement of serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total bilirubin, total protein, and albumin as well as ELISA assay of the oxidative stress markers such as glutathione (GSH) and malondialdehyde (MDA). The liver was dissected and processed for histopathological investigation and scoring. Statistical analysis was performed to investigate the significance of each result.Results: The study results revealed severe liver damage due to MTX administration in the negative control (induced-non treated) group in comparison with healthy group, also there was significant hepatoprotective effect after administration of the crude extract of E. heterophyllus, and flavonoid fraction from E. heterophyllus shown after biochemical liver function tests and anti-oxidant properties demonstrated by the measurement of oxidative stress markers MDA and GSH. The crude extract of E. heterophyllus shown superior hepatoprotective and antioxidant effect. Histopathological scoring showed a remarkable decrease in the scores of the treatment groups in comparison with the high score in the MTX only treated group.Conclusions: MTX administered in a dose of 20 mg/kg for 3 successive days causes marked liver injury, while treatment with the crude extract and flavonoid fraction of E. heterophyllus significantly ameliorates MTX-induced liver damage, although the crude extract of E. heterophyllus seems to have the most hepatoprotective properties.

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“…Several agents, including ursodeoxycholic acid (UDCA), omega-3 fatty acids, black seed oil, virgin coconut oil, and vitamin E, are used to prevent chemotherapy-induced liver damage (5)(6)(7)(8)(9). The objective of this study was to investigate the clinical hepatoprotective effect and safety of UDCA and/or vitamin E in pediatric patients with ALL, who were in the maintenance phase of treatment.…”

Section: Introductionmentioning

confidence: 99%

Effect of ursodeoxycholic acid and vitamin E in the prevention of liver injury from methotrexate in pediatric leukemia

Bordbar

Shakibazad

Fattahi

et al. 2018

Turk J Gastroenterol

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Virgin coconut oil supplementation attenuates acute chemotherapy hepatotoxicity induced by anticancer drug methotrexate via inhibition of oxidative stress in rats

Cited by 60 publications

References 44 publications

Dietary coconut oil ameliorates skin contact hypersensitivity through mead acid production in mice

Dietary coconut oil ameliorates skin contact hypersensitivity through mead acid production in mice

The Protective Effects of Echinops Heterophyllus Aqueous Extract Against Methotrexate-Induced Hepatotoxicity in Rabbits

Effect of ursodeoxycholic acid and vitamin E in the prevention of liver injury from methotrexate in pediatric leukemia

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