Virilization Secondary to Androgen-Secreting Tumor of the Ovary: A Report of Three Cases and Review of Literature

Kale, K. V.; Chauhan, Anahita; Kalappa, Smita

doi:10.1007/s13224-017-1087-z

Cited by 2 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, the presence of clitoromegaly, deepening of voice and the significantly elevated serum 17-OHP and androgen levels prompted us to consider alternative diagnoses. The presence of polycystic ovaries has been reported in a patient with an androgen-secreting SCT–NOS [11] and an androgen-secreting Sertoli–Leydig cell tumor [12]. In both cases, there was enlargement of the involved ovaries leading to gross asymmetry of bilateral ovarian sizes, similar to our case.…”

Section: Discussionsupporting

confidence: 84%

“…ACTH stimulation test was performed in 10 cases (including the current case) with elevated baseline 17-OHP levels. No response or insignificant changes were seen in eight cases (80%), including the current case [11, 25, 27, 29, 33–35], while positive 17-OHP responses to ACTH stimulation were observed in two cases (20%) (see legend of Table 3 for the definition of a positive response) [30, 31]. The expression of ACTH receptor may explain the positive 17-OHP response to ACTH stimulation in the minority of cases of SCT–NOS, as the expression of ACTH receptor mRNA was demonstrated in the tumoral tissue of one reported case of SCT–NOS with slightly elevated 17-OHP but not in the ovarian control tissue, although no ACTH stimulation test was performed [24].…”

Section: Discussionmentioning

confidence: 91%

See 1 more Smart Citation

Hyperandrogenism, Elevated 17-Hydroxyprogesterone and Its Urinary Metabolites in a Young Woman with Ovarian Steroid Cell Tumor, Not Otherwise Specified: Case Report and Review of the Literature

Wong

Chan

Wong³

et al. 2019

Case Reports in Endocrinology

View full text Add to dashboard Cite

We describe a case of a 24-year-old overweight woman who presented with hirsutism, secondary amenorrhea, clitoromegaly, and symptoms of diabetes mellitus (DM). While a diagnosis of polycystic ovary syndrome (PCOS) with its associated metabolic disturbances was initially considered, serum total testosterone, androstenedione, and 17-hydroxyprogesterone (17-OHP) measured by liquid chromatography tandem mass spectrometry (LC-MS/MS) were significantly increased. As 17-OHP did not increase upon ACTH (Synacthen) stimulation and the urinary steroid profile (USP) was compatible with an ovarian source of 17-OHP excess rather than adrenal, non classical congenital adrenal hyperplasia (NCCAH) was unlikely and an androgen-secreting tumor was suspected. Transabdominal ultrasound revealed the presence of an enlarged right ovary with a polycystic ovary morphology and no discrete mass. Transvaginal ultrasound and [18F]− fluorodeoxyglucose positron emission tomography–computed tomography (FDG PET–CT) enabled the localization of a right ovarian tumor. Laparoscopic right salpingo-oophorectomy was performed and a histological diagnosis of steroid cell tumor, not otherwise specified (SCT–NOS) was made. Hyperandrogenism and menstrual disturbances resolved postoperatively. A literature review revealed that 17-OHP-secreting SCT–NOS may uncommonly show positive responses to ACTH stimulation similar to 21-hydroxylase deficiency. Alternatively, USP might be useful in localizing the source of 17-OHP to the ovaries. Its diagnostic performance should be evaluated in further studies.

show abstract

Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 91%

Hyperandrogenism, Elevated 17-Hydroxyprogesterone and Its Urinary Metabolites in a Young Woman with Ovarian Steroid Cell Tumor, Not Otherwise Specified: Case Report and Review of the Literature

Wong

Chan

Wong³

et al. 2019

Case Reports in Endocrinology

View full text Add to dashboard Cite

show abstract

“…In a case series of ovarian steroid cell tumors [ 8 ], 81% presented with elevated baseline 17OHP, with a small minority having a response to ACTH stimulation [ 9 ]. Possible hypotheses include the expression of ACTH receptor on tumor cells, or spurious increase in response to ACTH stimulation due to cross-reactivity of immunoassays with cortisol or other precursors.…”

Section: Discussionmentioning

confidence: 99%

Sertoli-Leydig Cell Tumor as a Cause of Elevated 17-OH Progesterone

Chong,

Wong,

Ang

et al. 2024

JCEM Case Reports

View full text Add to dashboard Cite

Virilizing ovarian tumors are rare but a clinically important diagnosis in a patient presenting with hyperandrogenism. Workup of hyperandrogenism is challenging with a broad range of differentials, including adrenal and ovarian pathology, tumoral or nontumoral in nature. Baseline follicular-phase 17-hydroxyprogesterone (17OHP) measurement is part of the investigation algorithm, and elevated levels are often associated with nonclassic congenital adrenal hyperplasia (NCCAH), which can have its first presentation in adolescence or adulthood. This case describes a young adult woman of reproductive age presenting with menstrual irregularity, raised testosterone, and 17OHP. After extensive workup and serial follow-up, she was found to have a Sertoli-Leydig cell tumor of the left ovary and underwent successful laparoscopic salpingo-oophorectomy with normalization of her menstrual irregularity and biochemical resolution of her testosterone and 17OHP levels.

show abstract

Virilization Secondary to Androgen-Secreting Tumor of the Ovary: A Report of Three Cases and Review of Literature

Cited by 2 publications

References 4 publications

Hyperandrogenism, Elevated 17-Hydroxyprogesterone and Its Urinary Metabolites in a Young Woman with Ovarian Steroid Cell Tumor, Not Otherwise Specified: Case Report and Review of the Literature

Hyperandrogenism, Elevated 17-Hydroxyprogesterone and Its Urinary Metabolites in a Young Woman with Ovarian Steroid Cell Tumor, Not Otherwise Specified: Case Report and Review of the Literature

Sertoli-Leydig Cell Tumor as a Cause of Elevated 17-OH Progesterone

Contact Info

Product

Resources

About