Virological and immunological studies on a fatal case of infectious mononucleosis

Crawford, D. H.; Epstein, M. A.; Achong, B. G.; Finerty, S.; Newman, John A.; Liversedge, S.; Tedder, Richard S.; Stewart, J. W.

doi:10.1016/s0163-4453(79)80053-5

Cited by 38 publications

(18 citation statements)

References 38 publications

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“…Physical examination on 8 August showed an emaciated boy (weight 13 kg, height 105 cm) with a maculopapular eruption on the back, ocular telangiectasia, postnasal discharge, bilateral crepitant rales over the lung fields, and a firm, non-mobile 10 x 15 cm mass in the right abdominal quadrant. His gait was ataxic.…”

Section: Case Reportmentioning

confidence: 99%

Epstein-Barr-virus-carrying lymphoma in a patient with ataxia-telangiectasia.

Saemundsen¹,

Berkel²,

Henle³

et al. 1981

BMJ

103

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Section: Case Reportmentioning

confidence: 99%

Epstein-Barr-virus-carrying lymphoma in a patient with ataxia-telangiectasia.

Saemundsen¹,

Berkel²,

Henle³

et al. 1981

BMJ

103

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“…This suppression may indeed be a defense mechanism that limits the proliferation of B cells, resulting in the usually self-limited course of IM. A fatal outcome of IM may result from unrestrained lymphoproliféra tion due to a failure of this suppressive mechanism [8,33]. On the other hand, in rare instances, the suppression/cytotoxic effect on B cells may become abnor mally severe and result in pathologic hypogamma globulinemia [9,22,30].…”

Section: Discussionmentioning

confidence: 99%

Sequential Changes of the Five Immunoglobulin Classes and Other Responses in Infectious Mononucleosis

Bahna

Heiner

Horwitz

1984

Int Arch Allergy Immunol

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Serum total IgG, IgA, IgM, IgD, and IgE concentrations, heterophil antibody titer, Epstein-Barr virus (EBV)-specific antibodies titer, and hematologic changes were studied longitudinally in 19 patients with EBV-induced infectious mononucleosis who were followed up for 1.5–34 months. In 9 patients, the changes in these variables were compared with baseline data on a pre-illness serum sample. All 5 immunoglobulins (Ig) showed a significant rise during the acute illness followed by a drop during convalescence, and a gradual ‘normalization’ within several months to a year. On the average, IgE peaked to 276% during the first week, IgM to 176% at about 10 days, IgA to 154% at 15–20 days, IgG to 135% at 10–15 days, and IgD to 141% during the first 2 months after onset. IgE and IgM levels were significantly suppressed during convalescence by an average of about 40 and 25% of pre-illness level, respectively. A relationship was noted between Ig rise and the increase in circulating atypical lymphocytes. The data clearly demonstrate the polyclonal nature of Ig production during the acute phase of EBV-induced mononucleosis, with a striking and early reactivity of IgE.

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“…Recently, a broader etiological role has been attributed to the virus in lymphoproliferative disorders in immunodeficient individuals [ Filipowich et al, 1980;Hanto et al, 198 1 ;Purtilo, 198 11. In them EBV induce polyclonal lymphoproliferative disorders of varying severity, from acute fatal IM to prolonged chronic disease [Purtilo et al, 1977;Britton et al, 1978;Crawford et al, 1979;Filipowich et al, 1980;Purtilo, 1981;Purtilo and Linder, 19831. The association of EBV with an illness is usually evidenced by a virus-specific humoral response in the patient, increased excretion of the virus into the oral cavity, and the presence of EBV-genomes in the cells of affected sites or malignant tissues.…”

Section: Epstein-barr Virus (Ebv) Is a B-lymphocyte Virusmentioning

confidence: 99%

Antibody response to epstein‐barr virus antigens in patients with chronic viral infection

Roubalová

Roubal

Skopový

et al. 1988

Journal of Medical Virology

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We tested antibody titres against Epstein-Barr virus (EBV) antigens in patients suffering from chronic viral disease and compared them with those determined in sex- and age-matched healthy controls. Patient sera showed signs of active EBV infection [antibodies against early antigen (EA) and/or viral capsid antigen (VCA) in the IgM or IgA classes] significantly more frequently than the control group. Correspondingly, geometric mean titres (GMT) of antibodies against all viral antigens were elevated in the patients. The strongest association with EBV was observed in patients whose clinical symptoms closely resembled infectious mononucleosis: 92% of the subjects in this subgroup possessed anti-EA and 41 and 25% had IgM and IgA anti-VCA antibody, respectively. In patients with signs of lymphoproliferation only and in those suffering from frequent respiratory infections the association with EBV was less marked but still significant. Patients with transient defects in humoral and cellular immunity mounted higher titres against VCA in the IgG class than those without immune defects.

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Virological and immunological studies on a fatal case of infectious mononucleosis

Cited by 38 publications

References 38 publications

Epstein-Barr-virus-carrying lymphoma in a patient with ataxia-telangiectasia.

Epstein-Barr-virus-carrying lymphoma in a patient with ataxia-telangiectasia.

Sequential Changes of the Five Immunoglobulin Classes and Other Responses in Infectious Mononucleosis

Antibody response to epstein‐barr virus antigens in patients with chronic viral infection

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