Virtual screening of flavonoids from Jatropha gossypiifolia L. as potential drugs for diabetic complications

Cañizares-Carmenate, Yudith; Díaz-Amador, Roberto; Mayra, Mirtha; Tran, Tan Quoc; Torrens, Francisco; Alberto, J. A. Gόmez-Treviño J.

doi:10.53388/tmr20220131261

Cited by 1 publication

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“…[5][6][7] As early as 2000 years ago, the ancient Chinese medical book "Huangdi Neijing" has records of the diagnosis and treatment of diabetes. [8] In traditional Chinese medicine (TCM), diabetes is called "Xiaoke" disease, which is caused by "Yin deficiency" and leads to frequent drinking and urination. Natural compounds such as curcumin and mangiferin are effective in treating diabetes complications.…”

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confidence: 99%

Association between color value of tongue and T2DM based on dose-response analyses using restricted cubic splines in China: A cross-sectional study

Tian,

Sun,

Wang

et al. 2024

Medicine

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This study aimed to explore the relationship between international commission on illumination (CIE) L*a*b* color value of tongue and type 2 diabetes mellitus (T2DM). We used restricted cubic spline method and logistic regression method to assess the relationship between CIE L*a*b* color value of tongue and T2DM. A total of 2439 participants (991 T2DM and 1448 healthy) were included. A questionnaire survey and tongue images obtained with tongue diagnosis analysis-1 were analyzed. As required, chi-square and t tests were applied to compare the T2DM and healthy categories. Our findings suggest the 95% confidence interval and odds ratio for body mass index, hypertension, and age were 0.670 (0.531–0.845), 13.461 (10.663–16.993), and 2.595 (2.324–2.897), respectively, when compared to the healthy group. A linear dose-response relationship with an inverse U-shape was determined between CIE L* and CIE a* values and T2DM (P < .001 for overall and P < .001 for nonlinear). Furthermore, U-shaped and linear dose-response associations were identified between T2DM and CIE b* values (P = .0160 for nonlinear). Additionally, in adults, the CIE L*a*b* color value had a correlation with T2DM. This novel perspective provides a multidimensional understanding of traditional Chinese medicine tongue color, elucidating the potential of CIE L*a*b* color values of tongue in the diagnosis of T2DM.

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