Virucidal activity and mechanism of action of cetylpyridinium chloride against SARS-CoV-2

Okamoto, Nako; Saito, Akatsuki; Okabayashi, Tamaki; Komine, Akihiko

doi:10.1016/j.ajoms.2022.04.001

Cited by 15 publications

(18 citation statements)

References 26 publications

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“…Clopyralid, having a pyridine ring, belongs to picolinic acid family. Compounds with pyridine cations, such as cetylpyridinium chloride or pyridinium formate, can inactivate tailed phages and human viruses [ 68 , 69 , 70 ]. Additionally, picolinic acid has been proven as a virucidal agent against human viruses, such as CHIKV, VZV or SARS-CoV-2 [ 71 , 72 , 73 ].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial and Virucidal Potential of Morpholinium-Based Ionic Liquids

Michalski

Sommer

Rossmanith

et al. 2023

IJMS

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Witnessed by the ongoing spread of antimicrobial resistant bacteria as well as the recent global pandemic of the SARS-CoV-2 virus, the development of new disinfection strategies is of great importance, and novel substance classes as effective antimicrobials and virucides are urgently needed. Ionic liquids (ILs), low-melting salts, have been already recognized as efficient antimicrobial agents with prospects for antiviral potential. In this study, we examined the antiviral activity of 12 morpholinium based herbicidal ionic liquids with a tripartite test system, including enzyme inhibition tests, virucidal activity determination against five model viruses and activity against five bacterial species. The antimicrobial and enzymatic tests confirmed that the inhibiting activity of ILs corresponds with the number of long alkyl side chains and that [Dec2Mor]+ based ILs are promising candidates as novel antimicrobials. The virucidal tests showed that ILs antiviral activity depends on the type and structure of the virus, revealing enveloped Phi6 phage as highly susceptible to the ILs action, while the non-enveloped phages PRD1 and MS2 proved completely resistant to ionic liquids. Furthermore, a comparison of results obtained for P100 and P001 phages demonstrated for the first time that the susceptibility of viruses to ionic liquids can be dependent on differences in the phage tail structure.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial and Virucidal Potential of Morpholinium-Based Ionic Liquids

Michalski

Sommer

Rossmanith

et al. 2023

IJMS

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“…(Ferrer et al, 2021) Esta mayor efectividad del cloruro de cetilpiridinio puede ser explicada por su una alta sustantividad al tejido dental, debido a la capacidad del cloruro de cetilpiridinio de adsorberse al esmalte recubierto de biofilm bacteriano lo que confiere mayor sustantividad a la molécula (Rizwana, 2013) lo que prolonga su actividad antiviral en saliva, (Muñoz et al, 2021) además, es muy seguro para el uso humano, casi sin efectos colaterales a largo plazo. (Okamoto et al, 2022) Si bien la clorhexidina demuestra una acción virucida similar al cloruro de cetilpiridinio y presentar mayor sustantividad (Seneviratne et al, 2020), se han manifestado varios efectos colaterales como tinción de lengua y dientes al ser utilizado diariamente durante tres semanas, aunque estos efectos son reversibles y fáciles de solucionar (Tadakamadla et al, 2019). Sin embargo, se reportan efectos colaterales más graves como lo indican Tribble et al, que describen que enjuagarse la boca dos veces al día con una solución de clorhexidina al 0,12% durante una semana produce cambios de al menos 5 mm/Hg en la presión arterial sistólica en individuos sanos.…”

Section: Discussionunclassified

Efectividad de los enjuagues bucales en la reducción de la carga viral de SARS-CoV-2 en la saliva. Una revisión narrativa

Ramos

Samaniego²,

Cordero³

2022

RSD

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La detección del virus del síndrome respiratorio severo agudo coronavirus 2 (SARS-CoV-2) en los fluidos orales y la elevada generación de aerosoles durante los procedimientos odontológicos ha llevado a la necesidad de buscar medidas para controlar la trasmisión de esta enfermedad. El Objetivo de este estudio es presentar la evidencia clínica disponible sobre la reducción de la carga viral y la acción virucida de diferentes antisépticos orales contra el SARS-CoV-2, y proponer su utilización como estrategia preventiva eficaz previo a la atención odontológica. Existe evidencia clínica sobre el uso de varios enjuagues bucales en distintas concentraciones y tiempos para reducción de la carga viral del SARS-CoV-2 en la saliva. Esta revisión de la literatura se centra en la evidencia clínica disponible, que indique el uso de enjuagues bucales como una medida preventiva eficaz en la reducción de la carga viral salival de SARS-CoV-2 para evitar la transmisión cruzada de la enfermedad Covid-19 durante los tratamientos odontológicos. Se realizó la búsqueda bibliográfica de la información disponible desde septiembre del 2020 hasta mayo de 2022, en PubMed, Google Scholar y Cochrane. La clorhexidina al 0,12%, la yodopovidona al 0,5-1 % o el cloruro de cetilpiridinio al 0,04-0,075 % reducen la carga viral de SARS-CoV-2 en saliva, pudiendo ser utilizados para reducir el riesgo de contagio de SARS-CoV-2.

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“…Formulations including hydrogen peroxide, benzalkonium chloride, dequalinium chloride, chlorhexidine, cetylpyridinium chloride, octenidine dihydrochloride, povidone–iodine, alkaline solutions, ethanol, hexetidine, cyclodextrin, polyaminopropyl biguanide, bioflavonoids, hypochlorous acid, delmopinol, silver nanoparticles, combination surfactants, essential oils, hydroxyapatite, glycyrrhizic acid, and/or sodium fluoride have been assessed. 150 , 154 , 169 , 172 , 174 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 182 , 183 , 184 , 185 , 186 Efficacy during in vitro or in vivo experiments has yielded variable results. Komine et al 175 did not find efficacy for chlorhexidine.…”

Section: Disinfectants and Topical Mucosal Applicationmentioning

confidence: 99%

“… 150 , 177 , 179 , 180 Cetylpyridinium chloride in various dilutions inactivates virus, and the mechanism of action in part appears to be related to the interruption of the Spike protein/receptor complex. 150 , 169 , 186 The degree of product dilution has a considerable impact. 150 , 176 Methods of virucidal determination have also been variable and have included genetic amplification (reverse transcription‐polymerase chain reaction [RT‐PCR]), antigen detection, and viral culture.…”

Section: Disinfectants and Topical Mucosal Applicationmentioning

confidence: 99%

Disinfection and decontamination in the context of SARS‐CoV‐2‐specific data

Cimolai

2022

Journal of Medical Virology

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Given the high transmissibility of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) as witnessed early in the coronavirus disease 2019 (COVID‐19) pandemic, concerns arose with the existing methods for virus disinfection and decontamination. The need for SARS‐CoV‐2‐specific data stimulated considerable research in this regard. Overall, SARS‐CoV‐2 is practically and equally susceptible to approaches for disinfection and decontamination that have been previously found for other human or animal coronaviruses. The latter have included techniques utilizing temperature modulation, pH extremes, irradiation, and chemical treatments. These physicochemical methods are a necessary adjunct to other prevention strategies, given the environmental and patient surface ubiquity of the virus. Classic studies of disinfection have also allowed for extrapolation to the eradication of the virus on human mucosal surfaces by some chemical means. Despite considerable laboratory study, practical field assessments are generally lacking and need to be encouraged to confirm the correlation of interventions with viral eradication and infection prevention. Transparency in the constitution and use of any method or chemical is also essential to furthering practical applications.

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Virucidal activity and mechanism of action of cetylpyridinium chloride against SARS-CoV-2

Cited by 15 publications

References 26 publications

Antimicrobial and Virucidal Potential of Morpholinium-Based Ionic Liquids

Antimicrobial and Virucidal Potential of Morpholinium-Based Ionic Liquids

Efectividad de los enjuagues bucales en la reducción de la carga viral de SARS-CoV-2 en la saliva. Una revisión narrativa

Disinfection and decontamination in the context of SARS‐CoV‐2‐specific data

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