VIRULENCE-LINKED COLONIAL AND MORPHOLOGICAL VARIATION IN
            <i>LEPTOSPIRA</i>

Faine, S.; Hoeden, J. Van Der

doi:10.1128/jb.88.5.1493-1496.1964

Cited by 35 publications

(12 citation statements)

References 3 publications

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“…It should be noted that similar linear motility mutants of L. interrogans have been obtained by others (9,21,23,24). Simpson and White reported differences in ultrastructure between linear and hook-shaped serovars (21).…”

Section: Fig 4 (A)supporting

confidence: 82%

Axial filament involvement in the motility of Leptospira interrogans

Bromley¹,

Charon²

1979

J Bacteriol

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Motility mutants of Leptospira interrogans serovar illini were isolated and analyzed by dark-field and electron microscopy. Mutants were obtained by screening for small colonies after nitrosoguanidine treatment. One class of mutants did not have hookor spiral-shaped ends. In addition, the axial filaments from these mutants were not coiled. An analysis of revertants of two of the mutants in this class indicated that the mutations were pleiotropic with respect to motility, hookand spiral-shaped ends, and axial filament coiling. We conclude that the axial filaments and the hook-and spiral-shaped ends are involved in L. interrogans motility.

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Section: Fig 4 (A)supporting

confidence: 82%

Axial filament involvement in the motility of Leptospira interrogans

Bromley¹,

Charon²

1979

J Bacteriol

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“…In this situation colonial morphology could be associated with virulence. The avirulent, weakly motile, unhooked leptospires formed small colonies, whereas the virulent, motile, hooked leptospires formed large colonies (7). Similar results were obtained by Petrov and Chernukha (14) with serovar mozdok.…”

supporting

confidence: 87%

Surface colonies of Leptospira interrogans

Wood¹,

Johnson²,

Palin³

1981

J Clin Microbiol

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Observations of colonial growth of Leptospira interrogans serovar pomona, BJ, on soft-agar (1% agar) plates revealed the presence of both surface and subsurface colonies. The organisms from both types of colonies appeared to be similar in motility, morphology, antigenic composition, and pathogenicity. Passage in vivo tended to produce a higher incidence of surface colonies, whereas passage in vitro tended to produce a higher incidence of subsurface colonies, suggesting the importance of environmental factors in determining the type of colony produced.

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“…Johnson and Harris (8) showed that virulent leptospires were less susceptible than avirulent leptospires to the lethal action of serotypespecific immune antibcdy and complement, although the immune antibody cross-agglutinated completely (4,8). Thus, there is no obvious serological difference between virulent and avirulent leptospirae.…”

Section: Discussionmentioning

confidence: 99%

“…Leptospira Reference Laboratory, Dunedin, New Zealand. L. icterohaemorrlhagiae (GP) was the avirulent straight form of L. icterohaemorrhagiae (GP-B), hooked, and virulent for guinea-pigs (4) and 10-day chick embryos, freshly reisolated in culture after its second guinea pig passage. L. zanonii (-E), virulent (carrier state for mice; 3), was freshly reisolated from mice after its fifth mouse passage; its avirulent cultured line was L. zanioni.…”

Section: Methodsmentioning

confidence: 99%

Natural Antibody in Mammalian Serum Reacting with an Antigen in Some Leptospires

Faine

Carter

1968

J Bacteriol

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Serum from normal mammals agglutinated and immobilized nonpathogenic Leptospira biflexa and agglutinated avirulent lines of pathogenic serotypes L. icterohaemorrhagiae and L. zanoni. Virulent lines of L. icterohaemorrhagiae and L. zanoni were not affected, nor were any of three strains of L. pomona, one of which was avirulent. The active principle in serum was a f-macroglobulin which was heat-labile and reduced by 2-mercaptoethanol, and acted in conjunction with complement and lysozyme; it was absorbable from serum by Formalin-treated susceptible leptospires. The Formalin-stable receptor antigen, named "Z antigen," is associated with virulence rather than pathogenicity, but may not be a determinant of virulence.

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VIRULENCE-LINKED COLONIAL AND MORPHOLOGICAL VARIATION IN LEPTOSPIRA

Abstract: colony typical hooked Leptospira icterohaemorrhagiae was virulent for hamsters and guinea pigs. On cultivation, it was gradually replaced by a serologically identical small-colony avirulent straight mutant. The hooked virulent form was selected in vivo.

Cited by 35 publications

References 3 publications

Axial filament involvement in the motility of Leptospira interrogans

Axial filament involvement in the motility of Leptospira interrogans

Surface colonies of Leptospira interrogans

Natural Antibody in Mammalian Serum Reacting with an Antigen in Some Leptospires

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