Virulent T4 Acanthamoeba causing keratitis in a patient after swimming while wearing contact lenses in Southern Brazil

Fabres, Laura Fuhrich; Maschio, Vinícius José; Santos, Denise Leal dos; Kwitko, Sérgio; Marinho, Diane Ruschel; Araujo, Bruno Schneider de; Locatelli, Claudete Inês; Rott, Marilise Brittes

doi:10.1515/ap-2018-0050

Cited by 9 publications

(9 citation statements)

References 31 publications

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“…In addition, it is important to Sharma et al 2004;Zhang et al 2004;Spanakos et al 2006;Ertabaklar et al 2007;Ozkoc et al 2008;Booton et al 2009;Iovieno et al 2010;Nagyová et al 2010b;Niyyati et al 2010;Nuprasert et al 2010;Lorenzo-Morales el al. 2011;Arnalich-Montiel et al 2013b;Duarte et al 2013;Buerano et al 2014;Ghamilouie et al 2014a, b a;Ghamilouie et al 2014a, b b;Behera et al 2016;Padzik et al 2016;Tawfeek et al 2016;Alves et al 2018;Buchele et al 2018;Fabres et al 2018;Taher et al 2018;Bahreini et al 2019 note that in the cases described in this systematic review, the genotypes T1, T6, T14, T16, T17, T18, T19, T20, T21, and T22 were not found causing AK.…”

Section: Resultsmentioning

confidence: 72%

Genotype distribution of Acanthamoeba in keratitis: a systematic review

2021

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Acanthamoeba spp. are among the most worldwide prevalent protozoa. It is the causative agent of a disease known as Acanthamoeba keratitis, a painful and severe sight-threatening corneal infection that can lead to blindness. In recent years, the prevalence of Acanthamoeba keratitis has rapidly increased, growing its importance to human health. This systematic review aims to assess the distribution of Acanthamoeba sp. genotypes causing keratitis around the world, considering the sample collected type and the used identification method. Most of the cases were found in Asia and Europe. Not surprisingly, the T4 genotype was the most prevalent worldwide, followed by T3, T15, T11, and T5. Furthermore, the T4 genotype contains a higher number of species. Given the differences in pathology, susceptibility to treatment, and clinical outcome between distinct genotypes, it is essential to genotype isolates from Acanthamoeba keratitis cases to help to establish a better correlation between in vitro and in vivo activities, resulting in better drug therapies and successful treatment in cases of this important ocular infection.

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Section: Resultsmentioning

confidence: 72%

Genotype distribution of Acanthamoeba in keratitis: a systematic review

2021

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“…As noted in the scientific literature, 16,19,53,80–83 the first report of AK was described by Nagington in 1974 84 . In the following years, AK was mainly related to ocular trauma 31 .…”

Section: Acanthamoeba Keratitismentioning

confidence: 96%

“…16 Infection by Acanthamoeba starts on the epithelium and progresses slowly into the stroma. In most cases, AK is unilateral; however, evidence also suggests that it can affect both eyes, 16,32,53,77,78 with a reported incidence of 7.5% in the UK. 13 When treatment is inadequate, AK can lead to perforation or corneal melting.…”

Section: Definitionmentioning

confidence: 99%

“…126 Early diagnosis and the increased awareness of eye care professionals represent a good combination for better results. 30,53,124,150 Visual prognosis is affected by the corneal positioning of the inflammation, the severity of the disease when diagnosed 14 and the duration of treatment with effective therapies. 3,13 When corneal inflammation is located centrally, the patient may suffer from loss of stereopsis, 14 producing difficulty in depth perception.…”

Section: Visual Prognosismentioning

confidence: 99%

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Acanthamoeba keratitis: a review of biology, pathophysiology and epidemiology

Lacerda

Lira

2020

Ophthalmic Physiologic Optic

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Acanthamoeba keratitis is an infection caused by a unicellular protozoan of the genus Acanthamoeba that is universally widespread. Until now, most cases were reported in contact lens wearers, although it is also a reality for non‐wearers, mostly connected to corneal trauma. There is also a variation in incidence regarding the aetiology of the disease between developed and developing countries. Purpose This work is based on a literature review, and the main goal is to deepen the knowledge about Acanthamoeba keratitis, presenting the main risk factors and focusing on prevention actions for this type of corneal infection since the treatments are not always effective. It targets specialists in visual health to strengthen their knowledge in this area, as well as to allow them to better inform their patients about hygiene care, appropriate measures of disinfection and ways to minimise the risk of infection. At this stage, it is important to highlight the essential role that practitioners play in fitting, monitoring and following‐up patients to minimise the danger of infection. Recent findings It is well recognised that corneal trauma facilitates invasion by leaving an open door for microorganisms to penetrate the cornea. In addition to trauma, risk factors are mostly associated with patients’ behaviours, such as interaction of contact lenses with contaminated water in the shower, swimming pools and beaches, etc., lack of hygiene habits with contact lenses and respective cases, and the use of ineffective disinfecting solutions. The fact that a disinfecting solution is not completely effective against trophozoites and/or cysts, both forms of Acanthamoeba’s lifecycle, can cause the infection since one cyst alone leads to the emergence of a whole new population of Acanthamoeba. Summary It is necessary to reduce the risk of infection and, beyond the need to promote patient education to encourage correct CL hygiene behaviours, it should also be highlighted that there is an urgent need to enhance the efficacy of CL disinfection systems against all strains and both stages of Acanthamoeba through the creation of standardised methods. The ease of purchasing CLs without any supervision must also be considered a concern, and, in the near future, it is also important to develop and implement effective diagnostic methods and treatments for Acanthamoeba keratitis.

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“…Acanthamoeba spp. have been detected in swimming pools and spas, which confirms that these protozoans have a wide distribution in the environment and underscores the importance of not wearing CL in aquatic environments (CAUMO et al, 2009;FABRES et al, 2016;STAGGEMEIR et al, 2016;FABRES et al, 2018).…”

Section: Discussionmentioning

confidence: 66%

Pesquisa De Indicadores De Contaminação Na Carne De Charque Comercializada Em Supermercados E Feiras Livres

Barbosa¹,

Lima²,

Silva³

et al. 2021

Microbiologia: Clínica, Ambiental E Alimentos

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Direitos para esta edição cedidos à Atena Editora pelos autores.Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons.Atribuição-Não-Comercial-NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais. Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação com base em critérios de neutralidade e imparcialidade acadêmica.A Atena Editora é comprometida em garantir a integridade editorial em todas as etapas do processo de publicação, evitando plágio, dados ou resultados fraudulentos e impedindo que interesses financeiros comprometam os padrões éticos da publicação. Situações suspeitas de má conduta científica serão investigadas sob o mais alto padrão de rigor acadêmico e ético.

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Virulent T4 Acanthamoeba causing keratitis in a patient after swimming while wearing contact lenses in Southern Brazil

Cited by 9 publications

References 31 publications

Genotype distribution of Acanthamoeba in keratitis: a systematic review

Genotype distribution of Acanthamoeba in keratitis: a systematic review

Acanthamoeba keratitis: a review of biology, pathophysiology and epidemiology

Pesquisa De Indicadores De Contaminação Na Carne De Charque Comercializada Em Supermercados E Feiras Livres

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