Virus antibody in synovial fluid of rheumatoid and control patients.

Stanford, Fred

doi:10.1136/ard.33.4.342

Cited by 5 publications

(1 citation statement)

References 9 publications

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“…Several investigators studied specific virus antibodies in synovial tissue eluates, synovial fluids, and cryoprecipitates from them. As with serum levels in RA, there were no striking abnormalities (25)(26)(27). I n sum, there is no direct evidence for microbial involvement in RA (22).…”

Section: Discussionmentioning

confidence: 99%

Immunopathologic studies of rheumatoid arthritis.

Paget¹,

Anderson²,

Phillips³

1978

Arthritis & Rheumatism

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A sensitive complement‐dependent chromium release cytotoxicity assay was used to determine whether sera from rheumatoid arthritis (RA) patients contain antibody specific for an antigen on rheumatoid synovial cell cultures. Two hundred eight RA sera–RA synovial culture combinations were studied employing 21 sera and 16 synovial membranes; control combinations were derived from 5 normal sera and 10 degenerative joint disease synovial membranes. Anticomplementary activity of some rheumatoid sera was overcome using an increased complement concentration. The percent cytotoxicity of RA serum–RA culture combinations, both homologous and autologous, was not significantly greater than that of RA serum–control culture combinations. No correlation between duration of disease or duration of cell culture and percent cytotoxicity was found. Thus a unique antigen on cultured rheumatoid synovial cells was not recognized by rheumatoid serum antibody by use of this cytotoxicity assay.

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Section: Discussionmentioning

confidence: 99%

Immunopathologic studies of rheumatoid arthritis.

Paget¹,

Anderson²,

Phillips³

1978

Arthritis & Rheumatism

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Interferon triggers experimental synovitis and may potentiate auto-immune disease in humans

et al. 1984

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From these data it appears that IFN is capable of stimulating prostaglandin E and hyaluronic acid production by human synovial fibroblasts in vitro and of initiating an inflammatory reaction in animal joints. In chronic arthritis its production may result from persisting viral or other antigenic stimulation. IFN may enhance the immune response and mediate the inflammatory process in the joint. Its role in the pathogenesis of rheumatic and various other autoimmune diseases is undergoing further study.

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Immune Complexes in Rheumatic Disease

Woda

1976

The Lancet

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Virus antibody in synovial fluid of rheumatoid and control patients.

Cited by 5 publications

References 9 publications

Immunopathologic studies of rheumatoid arthritis.

Immunopathologic studies of rheumatoid arthritis.

Interferon triggers experimental synovitis and may potentiate auto-immune disease in humans

Immune Complexes in Rheumatic Disease

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