Virus de Epstein-Barr y su relación con el desarrollo del cáncer

Medina-Ortega, Ángela Patricia; López-Valencia, David; Mosquera-Monje, Sara Lucía; Mora-Obando, Diana; Dueñas-Cuellar, Rosa Amalia

doi:10.17533/udea.iatreia.v30n2a03

Cited by 10 publications

(8 citation statements)

References 68 publications

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“…Although ENKTL’S pathogenesis is not clear, there is a relationship between EBV infection and the development of ENKTL. A higher ENKT incidence has been observed in regions with high childhood prevalence of EBV (3% to 5.2%) as compared with just 0.3% in North American and European countries 3 8 10 11 .…”

Section: Discussionmentioning

confidence: 98%

Extranodal NK/T-Cell Lymphoma, Nasal Type, Extranasal and Ulcerative Blister Variant, Case Report

Chávez Dávila,

Pinos León,

Tello Astudillo

et al. 2023

Ann Dermatol

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The extranodal natural killer (NK) T-cell lymphoma of nasal type is a form of lymphoma that falls within the WHO/EORTC 2018 classification of cutaneous T-cell lymphomas. It is characterized for being aggressive, infrequent, and destroying midline facial structures; however, it can also be in primary or secondary form at extranasal sites, such as the skin or the gastrointestinal tract, among others. We report the case of an 18-year-old patient with an extranodal NK/T-cell lymphoma located in an extranasal site. The clinical presentation is characterized for being multifocal and with erythematous-violaceous plaques that progress to hemorrhagic blisters and necrotic ulcers. Although this type of lymphoma has been reported previously by others, the presence of blisters is an atypical finding, which we believe has been described only in one case in the medical literature.

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Section: Discussionmentioning

confidence: 98%

Extranodal NK/T-Cell Lymphoma, Nasal Type, Extranasal and Ulcerative Blister Variant, Case Report

Chávez Dávila,

Pinos León,

Tello Astudillo

et al. 2023

Ann Dermatol

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“…PD-1 signaling is mediated by its two ligands, PD-L1 and PD-L2, which are expressed primarily by cancer cells, leading to immune tolerance [32]. In addition, it is known that IL-10 influences cell proliferation, angiogenesis and inflammatory response [33]. TGF-B1 has been associated with the fact that when elevated levels of TGF-β are produced, a functional central TGF-β machinery is maintained to promote more aggressive malignant phenotypes [34].…”

Section: Epstein-barr Virusmentioning

confidence: 99%

MicroRNAs Encoded by Virus and Small RNAs Encoded by Bacteria Associated with Oncogenic Processes

et al. 2021

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Cancer is a deadly disease and, globally, represents the second leading cause of death in the world. Although it is a disease where several factors can help its development, virus induced infections have been associated with different types of neoplasms. However, in bacterial infections, their participation is not known for certain. Among the proposed approaches to oncogenesis risks in different infections are microRNAs (miRNAs). These are small molecules composed of RNA with a length of 22 nucleotides capable of regulating gene expression by directing protein complexes that suppress the untranslated region of mRNA. These miRNAs and other recently described, such as small RNAs (sRNAs), are deregulated in the development of cancer, becoming promising biomarkers. Thus, resulting in a study possibility, searching for new tools with diagnostic and therapeutic approaches to multiple oncological diseases, as miRNAs and sRNAs are main players of gene expression and host–infectious agent interaction. Moreover, sRNAs with limited complementarity are similar to eukaryotic miRNAs in their ability to modulate the activity and stability of multiple mRNAs. Here, we will describe the regulatory RNAs from viruses that have been associated with cancer and how sRNAs in bacteria can be related to this disease.

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“…Once these cells pass through the oropharynx, they transfer the virus to the epithelial cells, where it replicates to infect other cells ( Figure 2). (26,27) and -2) in cells with latent infection adhere to protein kinase RNAactivated (PKR), ribosomal protein 22 (L22), antigen associated with SLE (La), and retinoic acid inducible gene I (RIG-I). (36) This promotes the production of type I IFNs, pro-inflammatory cytokines and autoantibodies via the TLR3 signaling pathway.…”

Section: Ebv and Autoimmune Diseasesmentioning

confidence: 99%

Epstein-Barr virus infection as a predisposing factor for multiple sclerosis. An update from molecular biology, immunology and epidemiology

et al. 2019

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Introduction: Epstein-Barr virus is an infectious agent used to immortalize and induce polyclonal activation of B cells. It has been widely described that this virus produces changes in the cells it infects and in the immune response, and stimulates the development of autoimmune diseases.Objective: To characterize the association between Epstein-Barr virus and multiple sclerosis described in current scientific literature.Materials and methods: A 59-years range literature search was conducted in the PubMed, ScienceDirect, Redalyc and SciELO databases using the following MeSH terms: “Epstein-Barr virus, multiple sclerosis autoimmune diseases, autoimmune diseases of the nervous system”.Results: Many studies describe the association between Epstein-Barr virus and multiple sclerosis. It is believed that acute infection and viral reactivation promote the development of multiple sclerosis.Conclusions: It is necessary to conduct further research on the pathogenesis and morphophysiological and neuroimmunological changes –at the ecological, molecular, cellular, tissue, organic and systemic level– induced by the immune response and that favor the development of multiple sclerosis.

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Virus de Epstein-Barr y su relación con el desarrollo del cáncer

Cited by 10 publications

References 68 publications

Extranodal NK/T-Cell Lymphoma, Nasal Type, Extranasal and Ulcerative Blister Variant, Case Report

Extranodal NK/T-Cell Lymphoma, Nasal Type, Extranasal and Ulcerative Blister Variant, Case Report

MicroRNAs Encoded by Virus and Small RNAs Encoded by Bacteria Associated with Oncogenic Processes

Epstein-Barr virus infection as a predisposing factor for multiple sclerosis. An update from molecular biology, immunology and epidemiology

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