Virus excretion and cell‐mediated immunity during cytomegalovirus infection among healthy infants and children

Tanaka, Ryoko; Tanaka, Akira; Oizumi, Yoshihumi; Ishida, Nakao; Numazaki, Yoshio

doi:10.1002/jmv.1890180104

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…This latter observation confirms previous studies' findings of long-lasting suppression of lymphocyte blastogenic responses to HCMV in adults after mononucleosis [25] and in adolescents after asymptomatic primary HCMV infection [4]. Similar findings were observed in babies with perinatal or postnatal HCMV infection [26,27], in congenitally infected children, and in their mothers [28][29][30][31].…”

Section: Discussionsupporting

confidence: 81%

Lymphoproliferative Response in Primary Human Cytomegalovirus (HCMV) Infection Is Delayed in HCMV Transmitter Mothers

et al. 2006

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Background. The T cell-mediated immune response to human cytomegalovirus (HCMV) after primary infection, as well as the determinants of intrauterine transmission, are poorly understood.Methods. Sequential peripheral blood leukocyte samples from 74 pregnant women and 29 nonpregnant individuals with primary infection were examined for HCMV-specific CD4 + T cells by cytokine flow cytometry (CFC) and lymphoproliferative response (LPR) analysis. Immunological results for 19 transmitter and 21 nontransmitter mothers were compared.Results. Comparison of CFC and LPR analysis results showed that (1) there was no difference between pregnant and nonpregnant individuals; (2) HCMV-specific CD4 + T cells were detected by CFC, in the absence of an LPR to HCMV, in the great majority or the totality (according to different intervals) of samples collected from both pregnant and nonpregnant individuals during follow-up; and (3) LPR to HCMV was significantly ( ) lowered or delayed in transmitter mothers, compared with that in nontransmitter mothers.Conclusions. Pregnancy does not influence the HCMV-specific immune response. A dissociation between CFC response and LPR is commonly observed in patients with primary infections, and ad hoc studies aimed at understanding the mechanism(s) of the reduced LPR in transmitter mothers are warranted.

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Section: Discussionsupporting

confidence: 81%

Lymphoproliferative Response in Primary Human Cytomegalovirus (HCMV) Infection Is Delayed in HCMV Transmitter Mothers

et al. 2006

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“…Virus excretion may continue for > 2 years, with virus usually being cleared from the throat before it is cleared from the urine [18,19]. Clearance depends on the acquisition of specific cell‐mediated immunity, rather than the appearance of antibodies against the virus [20]. The occurrence of CMV infection in the two brothers, who were both breast fed for > 1 year by their seropositive mother, and continual excretion of virus for 2–3 years is no different from the natural history of the condition in normal individuals.…”

Section: Discussionmentioning

confidence: 99%

“…2 years, with virus usually being cleared from the throat before it is cleared from the urine [18,19]. Clearance depends on the acquisition of specific cell-mediated immunity, rather than the appearance of antibodies against the virus [20]. The occurrence of CMV infection in the two brothers, who were both breast fed for .…”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus infection in infants with autoimmune lymphoproliferative syndrome (ALPS)

Arkwright

Rieux-Laucat

Deist

et al. 2000

Clinical and Experimental Immunology

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SUMMARYFas-mediated apoptosis may be one of the effector pathways leading to the elimination of virus-infected cells. Cytomegalovirus (CMV) infection in two brothers with Fas deficiency associated with autoimmunity and benign lymphoproliferation (ALPS) provided a unique opportunity to study the clinical course of CMV infection in children with defective apoptosis. The clinical courses of two brothers with autosomal dominant ALPS who were infected with CMV in the neonatal period are described. CMV was detected from throat and urine culture from the brothers. ALPS was confirmed by in vitro anti-CD95 MoAb-induced T lymphocyte apoptosis assay and subsequent sequencing and identification of mutations in the Fas gene. A de novo mutation in the Fas gene, leading to a truncated cytoplasmic Fas product, was associated with autosomal dominant ALPS in a mother and her two sons. Both boys had evidence of CMV infection acquired early in infancy which cleared by the age of 2±3 years. There were no neurodevelopmental sequelae. The natural history of CMV infection in two infants with ALPS was similar to that described in normal children.

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Lymphocyte responses to human cytomegalovirus in different groups of patients in Britain and in adults from West Africa and the Middle East

et al. 1996

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Antibody prevalence and lymphocyte proliferation responses to cytomegalovirus (CMV) and herpes simplex virus (HSV) were compared in several different groups of patients: genitourinary medical (GUM) patients, hemophiliacs, men with clinical acquired immunodeficiency syndrome (AIDS) and cases of primary CMV mononucleosis, and also in adults in the general population (control subjects) comprising separate groups native to Britain, West Africa, and the Middle East. Among the British control subjects who were positive for CMV IgG, all were also positive against CMV antigen by the lymphocyte transformation test (LTT). However, among those who were CMV IgG-positive in the various groups of patients, 20-86.9% gave positive responses to CMV antigen by the LTT; moreover, 75.7% and 55.5% of the CMV IgG-positive healthy control subjects from West Africa and the Middle East, respectively, gave positive LTT responses to CMV antigen. When the same groups of patients were tested for responsiveness to HSV antigen by the LTT, there was good agreement between a positive result by this test and by serology in all except those with primary CMV mononucleosis (42.8%). Overall, lymphocyte responses to CMV were significantly impaired in healthy, CMV antibody-positive subjects from West Africa and the Middle East compared to similar subjects from Britain.

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Virus excretion and cell‐mediated immunity during cytomegalovirus infection among healthy infants and children

Cited by 4 publications

References 16 publications

Lymphoproliferative Response in Primary Human Cytomegalovirus (HCMV) Infection Is Delayed in HCMV Transmitter Mothers

Lymphoproliferative Response in Primary Human Cytomegalovirus (HCMV) Infection Is Delayed in HCMV Transmitter Mothers

Cytomegalovirus infection in infants with autoimmune lymphoproliferative syndrome (ALPS)

Lymphocyte responses to human cytomegalovirus in different groups of patients in Britain and in adults from West Africa and the Middle East

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