Virus Infection and Intussusception in Childhood

Gardner, P. S.; Knox, E. G.; Court, S. D. M.; Green, C. A.

doi:10.1136/bmj.2.5306.697

Cited by 76 publications

(19 citation statements)

References 12 publications

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“…Thus, together with the data that 11 of 30 cases with intussusception shed rotavirus, one could calculate a "proxy" odds ratio , which is 25.0 (95%CI = 9.40-66.5). This is as impressive a figure as that calculated for adenovirus in Gardner's study (19) (see previous section).…”

Section: What Will Be Needed To Address the Question Of Whether Intussupporting

confidence: 64%

“…Once attention was directed to the association between intussusception and adenovirus, several studies followed where it was demonstrated that a significantly larger number of patients with intussusception (26.3-90.1%) shed adenovirus than patients with other diseases (2.6-6.2%) or healthy controls (0-8.0%) (1,10,18,19,48,51,52,56). To take an example from Gardner et al's study (19), the odds ratio for having intussusception in the adenovirus-positive group over the adenovirus-negative group is calculated to be 25.7 (95%CI= 8.57-77.1), lending strong support for the role of adenovirus infection in the etiology of intussusception.…”

Section: Adenovirus: the Paradigm For Viral Infection And Intussuscepmentioning

confidence: 99%

“…To take an example from Gardner et al's study (19), the odds ratio for having intussusception in the adenovirus-positive group over the adenovirus-negative group is calculated to be 25.7 (95%CI= 8.57-77.1), lending strong support for the role of adenovirus infection in the etiology of intussusception.…”

Section: Adenovirus: the Paradigm For Viral Infection And Intussuscepmentioning

confidence: 99%

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Rotavirus Infection and Intussusception: A View from Retrospect

Nakagomi

2000

Microbiology and Immunology

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A live orally-administrable rhesus rotavirus (RRV) tetravalent (TV) vaccine, licensed in the U.S.A. and the European Union, was recalled from the market because it was suspected to increase the risk of intussusception during the week following immunization. In contrast, natural rotavirus infection is generally believed not to cause intussusception. Because my experience contributed to the first paper that linked intussusception with rotavirus infection, I have re-examined our own data published 22 years ago and other studies on this issue. I also made a case study of adenovirus and intussusception as a paradigm to establish an etiological association of viral infection and intussusception. My hypothesis postulated in this review is that natural infection of susceptible (or predisposed) infants with some rotavirus strains, probably serotype G3 rotaviruses, will result in an appreciable fraction of idiopathic intussusception. Thus, the number of rotavirus-induced intussusception cases may change reflecting the relative frequency of G3 strains, which I believe was much higher in the 70s than during the last two decades. The epidemiological data indicate that the RRV-TV vaccine triggers intussusception at a rate significantly higher than the background incidence rate following the week of vaccination, particularly after the first dose. In contrast, the data do not suggest that the cumulative incidence among the vaccine recipients increases accordingly, implicating that the risk of intussusception attributable to the RRV-TV vaccine may be minimal.

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Section: What Will Be Needed To Address the Question Of Whether Intussupporting

confidence: 64%

Section: Adenovirus: the Paradigm For Viral Infection And Intussuscepmentioning

confidence: 99%

Section: Adenovirus: the Paradigm For Viral Infection And Intussuscepmentioning

confidence: 99%

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Rotavirus Infection and Intussusception: A View from Retrospect

Nakagomi

2000

Microbiology and Immunology

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“…To date, intussusception has been associated most frequently with respiratory or GI tract infections, particularly those resulting from adenovirus and enterovirus. 10,11 The hypertrophied lymph node masses associated with these infections are believed to form the lead point that initiates the chain of events that result in intussusception. 12 In the United States, idiopathic intussusception occurs primarily in children younger than 2 years of age 13 and males are affected approximately 3 times more frequently than females.…”

Section: Intussusceptionmentioning

confidence: 99%

Intussusception, Infection, and Immunization: Summary of a Workshop on Rotavirus

Kombo¹,

Gerber

Pickering

et al. 2001

Pediatrics

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ABSTRACT. This article summarizes the proceedings of a workshop sponsored by the National Institutes of Health and the National Vaccine Program Office, and held in Bethesda, Maryland, on January 21, 2000. The objective of the meeting was to focus research toward an understanding of the basis for the possible association between intussusception and the reassortant rhesus-human rotavirus vaccine tetravalent (RRV-TV). After numerous reports of intussusception after administration of RRV-TV, the manufacturers of this vaccine voluntarily withdrew it from the United States market. The American Academy of Pediatrics, the Advisory Committee on Immunization Practices, and the American Academy of Family Physicians also withdrew their original recommendations for administration of RRV-TV to children at 2, 4, and 6 months of age. These actions will have global implications for the prevention of morbidity and mortality attributable to rotavirus infection. Benefit-cost ratios for the use of RRV-TV will be substantially different in developing countries compared with developed countries. Therefore, extensive research is needed in both of these settings, to further our understanding of the epidemiology, pathogenesis, and pathology of both rotavirus disease and intussusception to enable optimal prevention. The workshop reviewed the current understanding of the possible association between RRV-TV and intussusception, as well as the possible association between a variety of viral infections and intussusception. The workshop also identified critical areas of research regarding this possible association. This research will be essential not only for the development of safe and effective rotavirus vaccines, but for the development of other oral vaccines as well. Pediatrics 2001;108(2). URL: http://www. pediatrics.org/cgi/content/full/108/2/e37; rotavirus, intussusception, rhesus rotavirus vaccine tetravalent, workshop.

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“…When the presence of a virus agent was suspected, confirma-tion and identification was obtained by a neutralization test and in the case of adenovirus a complement fixation test as well. The techniques of virus isolation and neutralization were based on those originally described by Munro-Ashman, Gardner, Taylor & McDonald (1958) and Gardner, Knox, Court & Green (1962). All HeLa and Hep 2 cultures were kept a minimum of 28 days, while monkey kidney cells were kept about 14 days (see Table 1).…”

Section: Methodsmentioning

confidence: 99%

A comparative study of susceptibility of primary monkey kidney cells, Hep 2 cells and HeLa cells to a variety of faecal viruses

1963

Self Cite

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A comparative study of the susceptibility of monkey kidney, Hep 2 and HeLa cells to enteroviruses and adenoviruses is made. It seems that this Hep 2 cell line is as effective as the monkey kidney cells in their susceptibility to vaccine strains of polioviruses and far better than monkey kidney cells in their susceptibility to strains of ECHO 6 and ECHO 11 from clinical material. It is as effective as, or slightly better than, HeLa cells for the isolation of adenoviruses. It also compares favourably with monkey kidney cells for the isolation of other enteroviruses.We are most grateful to Glaxo Laboratories Ltd. for the supplies of monkey kidney cells used in this investigation.

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Virus Infection and Intussusception in Childhood

Cited by 76 publications

References 12 publications

Rotavirus Infection and Intussusception: A View from Retrospect

Rotavirus Infection and Intussusception: A View from Retrospect

Intussusception, Infection, and Immunization: Summary of a Workshop on Rotavirus

A comparative study of susceptibility of primary monkey kidney cells, Hep 2 cells and HeLa cells to a variety of faecal viruses

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