Viruses evolution &amp;ndash; an attempt of non-linear prognosis

Kordyum, V. A.

doi:10.7124/bc.0005d6

Biopolym. Cell

2001

DOI: 10.7124/bc.0005d6

|View full text |Cite

Viruses evolution – an attempt of non-linear prognosis

V. A. Kordyum

Abstract: В обзоре рассматриваются нетрадиционные представления о возможной эволюции инфекций (в основном вирусных) и анализируются ее механизмы. Становление Ноосферы как самодостаточ ной системы, альтернативной Биосфере, запустило взрывную (по своим масштабам и темпам) эволюцию вирусов. Отмечено несоответствие скорости изменчивости вирусов и появления новых инфекций, на основании чего вводится представление о «неопределенности инфекций». Прогнози руется ускорение эволюции инфекций (преимущественно вирусных) и ее направ… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Comparative analysis of the open reading frames protein genes of genotype 4 Hepatitis E virus in swine and wild boar

Lymanska

2023

J. Vet. Med. Biotechnol. Biosafety

View full text Add to dashboard Cite

The goal of this study was to determine the molecular diversity of the open reading frames (ORFs) ORF1, ORF2, ORF3 protein genes from full-length genomes of genotype 4 hepatitis E virus (HEV) from pigs and wild boars at protein and gene level. Statistical technique Shannon entropy was used for mutational analysis of ORF1–ORF3 protein genes to identify amino acid substitutions in the HEV 4 sequences isolated from pigs and wild boars that were most susceptible to mutations. Gene selective pressure for genes was estimated using Tajima’s neutrality test. The ORF regions of 11 swine and 11 wild boar genotype 4 HEV isolates with complete genomes from the GenBank database were analyzed comparatively. The total number of polymorphic sites was determined. Nonsynonymous (amino acid changing) and synonymous (amino acid preserving) substitutions were identified in ORF1, ORF2, ORF3 in swine and wild boar HEV 4 isolates. No evidence of recombination was found for ORFs in 11 swine HEV 4 isolates, ORF2, ORF3 in 8 wild boar HEV 4 isolates. However, a recombination fragment with a length of 430 nucleotides was detected in the ORF1 gene of 3 wild boar HEV 4 isolates. Positive D Tajima factors were determined for ORF1, ORF2, ORF3 genes of swine HEV 4 and ORF1, ORF2 genes of wild boar HEV 4. While a negative value of D Tajima’s factor was determined for ORF3 gene of wild boar HEV 4. Molecular characteristics showing principal distinctions between the open-reading frames of swine and wild boar genotype 4 hepatitis E virus were obtained. Wild boar ORF1 is characterized by lower nucleotide diversity π value (0.144) and higher number of segregated sites S value (1,688) comparing with higher π value (0.159) and lower S value (1,602) of swine ORF1. Positive values of D Tajima’s factor for ORF1, ORF2 ORF3 genes of swine HEV 4 and ORF1, ORF2 genes of wild boar HEV 4 show on positive selection of these genes. Negative value of D Tajima’s factor for ORF3 gene of wild boar HEV 4 indicates onto purifying selection decreasing variability in ORF3 gene of wild boar HEV 4. The largest number of amino acid variation sites (19.2%) was found for wild boar HEV 4 ORF3 followed by swine HEV 4 ORF3 (15.7%) comparing with other swine and wild boars HEV 4 ORFs

show abstract

Comparative analysis of the open reading frames protein genes of genotype 4 Hepatitis E virus in swine and wild boar

Lymanska

2023

J. Vet. Med. Biotechnol. Biosafety

View full text Add to dashboard Cite

show abstract

Characterization of swine hepatitis E virus genotype 3 open reading frames

Lymanska

2023

Veterinary Medicine: Inter-Departmental Subject Scientific Collection

View full text Add to dashboard Cite

The goal of this study was a determination of structural organization features of swine hepatitis E virus genotype 3 open reading frames. Gene selective pressure for genes was estimated using the Tajima’s neutrality test as implemented in MEGA 6. Shannon entropy was used for diversity detection at each position of open reading frames. Shannon entropy plots representing quantitative diversity at each amino acid (nucleotide) position of 11 swine HEV-3 isolates aligned sequences were calculated by software BioEdit. For phylogenetic analysis, nucleotide distances were analyzed using the neighbour-joining algorithm. Analysis of nucleotide, non-synonymous and synonymous distances was performed using MEGA6. Parameters of mutational analysis for swine hepatitis E virus genotype 3 open reading frames ORF1 – ORF3 were determined using Tajima’s neutrality test. Shannon entropy technique revealed that ORF3 is characterized by the most number of diverse amino acid residues (21,7 %) comparing with ORF1, ORF2 coding regions. Analysis of non-synonymous distances in ORF3 allowed to determine an order of evolutionary events in the history of swine HEV-3 isolates. Avian astroviruses strains were used as control because phylogenetic relationships among them correspond to the evolution history of their host species. Tree topology for swine HEV-3 ORF3 based on non-synonymous distances differs from tree structures based on nucleotide and synonymous distances. Positive values of D Tajima’s factor for ORF1, ORF2 of swine HEV-3 show on operating positive selection onto these coding regions. Negative value of D Tajima’s factor for ORF3 coding region indicates onto purifying selection

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Viruses evolution – an attempt of non-linear prognosis

Cited by 2 publications

References 51 publications

Comparative analysis of the open reading frames protein genes of genotype 4 Hepatitis E virus in swine and wild boar

Comparative analysis of the open reading frames protein genes of genotype 4 Hepatitis E virus in swine and wild boar

Characterization of swine hepatitis E virus genotype 3 open reading frames

Contact Info

Product

Resources

About