Viruses Special Issue “Transfusion-Transmitted Viral Infections”

Candotti, Daniel

doi:10.3390/v15010086

Cited by 3 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These advances have renewed interest in FDP as a modern, sterile, safe, and readily reconstituted blood component for hemostatic resuscitation, especially in prehospital and remote or austere environments. Discoveries of new human viruses, the implementation of new technologies for virus detection to exclude infected individuals, and the constitution of pools of repeat donors over the past two decades have significantly increased the safety of blood products and reduced the risk of transfusion-associated viral infections [50,51].…”

Section: History Of Fdpmentioning

confidence: 99%

Dried Plasma for Major Trauma: Past, Present, and Future

Peng,

Singh,

Rhind

et al. 2024

Life

View full text Add to dashboard Cite

Uncontrollable bleeding is recognized as the leading cause of preventable death among trauma patients. Early transfusion of blood products, especially plasma replacing crystalloid and colloid solutions, has been shown to increase survival of severely injured patients. However, the requirements for cold storage and thawing processes prior to transfusion present significant logistical challenges in prehospital and remote areas, resulting in a considerable delay in receiving thawed or liquid plasma, even in hospitals. In contrast, freeze- or spray-dried plasma, which can be massively produced, stockpiled, and stored at room temperature, is easily carried and can be reconstituted for transfusion in minutes, provides a promising alternative. Drawn from history, this paper provides a review of different forms of dried plasma with a focus on in vitro characterization of hemostatic properties, to assess the effects of the drying process, storage conditions in dry form and after reconstitution, their distinct safety and/or efficacy profiles currently in different phases of development, and to discuss the current expectations of these products in the context of recent preclinical and clinical trials. Future research directions are presented as well.

show abstract

Section: History Of Fdpmentioning

confidence: 99%

Dried Plasma for Major Trauma: Past, Present, and Future

Peng,

Singh,

Rhind

et al. 2024

Life

View full text Add to dashboard Cite

show abstract

“…The risk is much higher with platelet transfusions, a phenomenon especially important in oncohematology and bone marrow transplant patient care. The estimated transmission rate of bacterial infections is 1 per 2–5000 units of platelet transfusions with pooled, whole-blood-derived platelets and 1 per 15,000 units of platelet transfusions with single-donor apheresis preparations [ 1 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. This substantial difference is primarily due to the storage of platelet products at room temperature (22 ± 2 °C).…”

Section: Bacterial Transmissionmentioning

confidence: 99%

“…It is worth noting that the specific effects may vary depending on whether the platelets are derived from whole blood or obtained through apheresis. Consequently, these considerations highlight the importance of selecting the most appropriate platelet transfusion preparation method based on the clinical context, such as acute bleeding, prophylaxis, or the patient’s immunocompromised status, in the future [ 1 , 13 , 17 , 18 , 19 ].…”

Section: Bacterial Transmissionmentioning

confidence: 99%

“…There are significant geographical differences in the risk of bacterial transmissions worldwide [ 1 , 3 , 4 , 17 , 20 ]. It is essential to know that bacterial transfusion might induce acute reactions, very similar to transfusion reactions [ 13 , 21 , 22 ]. These different syndromes have practically identical symptoms, although they differ in terms of prevalence.…”

Section: Bacterial Transmissionmentioning

confidence: 99%

See 1 more Smart Citation

Transfusion-Transmitted Disorders 2023 with Special Attention to Bone Marrow Transplant Patients

et al. 2023

View full text Add to dashboard Cite

Transfusion medicine is traditionally a strong/fundamental part of clinical practice, saving hundreds of millions of lives. However, blood-borne or transmitted infections are a well-known and feared possibility, a risk we relentlessly mitigate. Pathogens are continuously and rather quickly changing, so during the last decade, many, sometimes exotic, new pathogens and diseases were recorded and analyzed, and some of them were proved to be transmitted with transfusions. Blood or blood component transfusions are carried out after cautious preparative screening and inactivation maneuvers, but in some instances, newly recognized agents might escape from standard screening and inactivation procedures. Here, we try to focus on some of these proven or potentially pathogenic transfusion-transmitted agents, especially in immunocompromised patients or bone marrow transplantation settings. These pathogens are sometimes new challenges for preparative procedures, and there is a need for more recent, occasionally advanced, screening and inactivation methods to recognize and eliminate the threat a new or well-known pathogen can pose. Pathogen transmission is probably even more critical in hemophiliacs or bone marrow transplant recipients, who receive plasma-derived factor preparations or blood component transfusions regularly and in large quantities, sometimes in severely immunosuppressed conditions. Moreover, it may not be emphasized enough that transfusions and plasma-derived product administrations are essential to medical care. Therefore, blood-borne transmission needs continued alertness and efforts to attain optimal benefits with minimized hazards.

show abstract