Museum cultural relics represent a special material cultural heritage, and modern interpretations of them are needed in current society. Based on the catalogue data of cultural relics published by the State Administration of Cultural Heritage, this paper analyzes the continuity and intermittentness of cultural relics in time series by using the method of continuity judgment of cultural relics, analyzes the aggregation and migration of cultural relics in space by using the method of spatial analysis, and then uses cosine similarity to explain the similarity distribution in space and time. The results show that the overall distribution of cultural relics exhibits the characteristics of class aggregation, dynasty aggregation and regional aggregation. From the perspective of a time scale, cultural relics have different “life cycles”, displaying continuity, intermittentness, and similarity. From the perspective of a spatial scale, the cultural relic distribution forms a small “cultural communication circle”, showing aggregation, migration, and similarity. The temporal and spatial distribution of cultural relics exhibited more similar characteristics among dynasties that were closer together than those that were far away.